A5101938618- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Electrowetting and Microfluidic Technologies
- Acute Myocardial Infarction Research
- Microfluidic and Bio-sensing Technologies
- DNA and Nucleic Acid Chemistry
- Vascular Procedures and Complications
- Hemoglobin structure and function
- Vestibular and auditory disorders
- Neurological disorders and treatments
- Endoplasmic Reticulum Stress and Disease
- Gout, Hyperuricemia, Uric Acid
- Trauma Management and Diagnosis
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Sleep and Work-Related Fatigue
- Hydrogels: synthesis, properties, applications
- Occupational Health and Performance
- Hearing, Cochlea, Tinnitus, Genetics
- Microfluidic and Capillary Electrophoresis Applications
- Peripheral Artery Disease Management
- Craniofacial Disorders and Treatments
National Yang Ming Chiao Tung University
2006-2024
Linkou Chang Gung Memorial Hospital
2024
University of Massachusetts Chan Medical School
2018-2021
National Taiwan Ocean University
2018
Chang Gung University
2012-2016
Chang Gung Memorial Hospital
2008-2016
Georgia Institute of Technology
2015
Paris Cardiovascular Research Center
2015
University of Chicago
2015
Rensselaer Polytechnic Institute
2015
Rationale: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether studies–identified genes, including PPAP2B , participate mechanotransduction mechanisms which vascular endothelia respond to local atherorelevant hemodynamics contribute the regional nature of atherosclerosis....
Dielectrophoresis (DEP), widely used to generate body forces on suspended particles, is investigated provide surface at the liquid-medium interfaces and pump a high-permittivity liquid in low-permittivity medium along virtual microchannel defined by an electric field between parallel plates. Because pumping pressure proportional square of intensity independent channel width, DEP advantageous as dimension shrinks down. The absence walls simplifies fabrication processes further increases its...
We aimed to investigate the association between ABO blood groups and risk of coronary artery disease (CAD) myocardial infartion (MI) in a young Taiwanese population.We retrospectively recruited 277 consecutive subjects (men younger than 45 years women 55 years) who underwent angiography (136 with documented CAD 129 without CAD) at our center, 2005 2008. Their were determined using standard agglutination techniques.Patients showed significantly different group distribution (O, 30.1%; A,...
Excitotoxic levels of glutamate represent a physiological stress that is strongly linked to amyotrophic lateral sclerosis (ALS) and other neurological disorders. Emerging evidence indicates role for neurodegenerative disease-linked RNA-binding proteins (RBPs) in the cellular response. However, relationships between excitotoxicity, RBP function, disease have not been explored. Here, using primary cortical motor neurons, we found excitotoxicity induced translocation select ALS-linked RBPs from...
Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress granules further implicates impaired responses in neurodegeneration. However, our knowledge the that evade incomplete. It also unclear whether influence proteome under conditions repression. To address these questions, quantitative proteomics approach was used to identify stress-induced arsenite-treated cells expressing either wild-type or...
The deposition of amyloid-β (Aβ) peptide, which is generated from amyloid precursor protein (APP), the pathological hallmark Alzheimer's disease (AD). Three APP familial AD mutations (D678H, D678N, and H677R) located at sixth seventh amino acid Aβ have distinct effect on aggregation, but their influence physiological roles remain unclear. We found that D678H mutation strongly enhances amyloidogenic cleavage APP, thus increasing production Aβ. This enhancement likely because acceleration...
Long 48 mm drug-eluting stents (DES) used to treat long coronary lesions decreases the number of needed and avoids stent overlapping. Disadvantages include difficulty in delivery size discrepancy between proximal distal landing zones. The present study analyzed rate procedural, immediate angiographic, 1-year clinical outcomes diffuse artery treated with everolimus-eluting (EES) compared multiple overlapping DES.
EWOD (electrowetting-on-dielectric) and LDEP (liquid dielectrophoresis) are investigated to provide digital analog microfluidic functions on an integrated chip respectively. By altering the frequency of applied voltage surrounding medium a device, we found that when using oil as applying AC signal 100 kHz, liquid column would be drawn follow thin connecting lines driving electrodes instead remaining top center electrodes. This new phenomenon is described in this paper regarded effect. Three...
The vestibular system is an important physiological sensory that contributes to human sense of proprioception and equilibrium. most common symptoms hypofunction are dizziness or impaired balance control. Balance tests the Dizziness Handicap Inventory (DHI) typically used clinically assess hypofunction. However, above assessments have subjective problems because different clinical evaluators discrepancies in comprehension questionnaire. Additionally, inertial measurement units (IMUs) been...
Sleep deprivation can lead to increased body weight and blood pressure (BP), but the latent effects of partial sleep related required night sentry duties within a short-term period on cardiometabolic characteristic changes in military personnel are unclear.
Abstract RNA polymerase II (pol II) is an essential enzyme that transcribes protein‐coding genes. It of rudimentary and medical importance to understand the mechanisms pol transcription. By passivating fused‐silica surface with biologically‐friendly polyethylene glycol (PEG), we immobilized a RNA‐primed double‐stranded DNA, termed DNA/RNA scaffold, build single molecule transcription assay using FRET (fluorescence resonance energy transfer) signals from donor on DNA acceptor as readouts,...
Abstract Excitotoxic levels of glutamate represent a physiological stress that is strongly linked to amyotrophic lateral sclerosis (ALS) and other neurological disorders. Emerging evidence indicates role for neurodegenerative disease RNA-binding proteins (RBPs) in the cellular response. However, relationships between excitotoxicity, RBP function pathology have not been explored. Here, we found excitotoxicity induced translocation select ALS-linked RBPs from nucleus cytoplasm within neurons....