A5025541827- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Technology and Human Factors in Education and Health
- Heart Failure Treatment and Management
- Functional Brain Connectivity Studies
- COVID-19 Clinical Research Studies
- Acute Ischemic Stroke Management
- Mental Health Research Topics
- Facial Nerve Paralysis Treatment and Research
- Healthcare Systems and Reforms
- Advanced MRI Techniques and Applications
- Reproductive System and Pregnancy
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Long-Term Effects of COVID-19
- Adipokines, Inflammation, and Metabolic Diseases
- Glioma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Cardiac Arrest and Resuscitation
- AI in cancer detection
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Biomedical Text Mining and Ontologies
California University of Pennsylvania
2025
University of Pennsylvania
2023-2025
Isfahan University of Medical Sciences
2017-2023
Abstract Our current understanding of the spread and neurodegenerative effects tau neurofibrillary tangles (NFTs) within medial temporal lobe (MTL) during early stages Alzheimer’s Disease (AD) is limited by presence confounding non-AD pathologies two-dimensional (2-D) nature conventional histology studies. Here, we combine ex vivo MRI serial histological imaging from 25 human MTL specimens to present a detailed, 3-D characterization quantitative NFT burden measures in space high-resolution,...
Abstract INTRODUCTION The generalizability of neuroimaging and cognitive biomarkers in their sensitivity to detect preclinical Alzheimer's disease (AD) power predict progression large, multisite cohorts remains unclear. METHOD Longitudinal demographics, T1‐weighted magnetic resonance imaging (MRI), scores 3036 cognitively unimpaired (CU) older adults (amyloid beta [Aβ]‐negative/positive [A–/A+]: 1270/1558) were included. Cross‐sectional longitudinal cognition medial temporal lobe (MTL)...
The anterior portion of the medial temporal lobe (MTL) is one first regions targeted by pathology in sporadic Alzheimer's disease (AD) and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging unique post-mortem dataset histology magnetic resonance (MRI) scans we aimed 1) develop an anatomically valid segmentation protocol entorhinal cortex (ERC), Brodmann Area (BA) 35, BA36 vivo 3 tesla (T)...
Introduction of simple bedside tools for assessing patients' condition in different settings improves triaging. However, these indices are less frequently used heart failure. This study aims to evaluate the utility shock index, age modified and age-modified index prediction in-hospital mortality acute decompensated failure individuals.We conducted this retrospective on 3652 individuals context Persian Registry Cardiovascular Disease/heart Shock were assessed during admission. Receiver...
Abstract Background Limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) is a neurodegenerative disease that often comorbid with Alzheimer's (AD) and for which there are no reliable specific chemical or PET biomarkers available. Recent progress in disease‐modifying treatments AD elevates the need vivo detection of LATE other diseases. The promise postmortem antemortem MRI studies they will lead to discovery patterns neurodegeneration associated pathology could be reliably detected...
Abstract Background Tau pathology and neurodegeneration in the medial temporal lobe (MTL) are highly associated Alzheimer’s Disease (AD). However, spatial pattern of neurodegeneration, contribution individual tau inclusion types, influence MTL co‐pathologies (i.e., TDP‐43) remain poorly understood. Traditional semi‐quantitative ratings or staging schemes capture limited variability severity provide no differentiation between types tangles, threads). We correlate quantitative measures from...
Abstract Background The medial temporal lobe (MTL) is the epicenter of both primary and concomitant molecular pathologies in Alzheimer’s disease (AD). intricate anatomy MTL has been subject extensive study over past two centuries. However, current PET MRI AD biomarkers use often crude parcellations that have not sufficiently validated vis‐à‐vis anatomical ground truth. Here we a unique dataset finely annotated serial histology, ex vivo antemortem 3T from 17 brain donors to train evaluate an...
Abstract Background The medial temporal lobe's (MTL) early involvement in tau pathology makes it a key focus the development of preclinical Alzheimer’s disease (AD) biomarkers. ROI analyses prior studies reported significant MTL structural differences cognitively normal individuals with and without β‐amyloid (A+/‐CN). Pointwise analysis, offering spatial information neurodegeneration, has potential to pinpoint “signature regions” pathological change, but been underexplored MTL. This study...
Abstract Background The anterior portion of the MTL is one first regions targeted by pathology in sporadic Alzheimer’s disease (AD) indicating potential for imaging metrics from this region to serve as valuable biomarkers. However, most existing automated approaches segmentation do not incorporate subregions, and few that fail account its complex anatomical variability. Leveraging a unique postmortem dataset consisting histology structural MRI scans we aimed develop an anatomically valid...
Abstract Background The medial temporal lobe's (MTL) early involvement in tau pathology makes it a key focus the development of preclinical Alzheimer’s disease (AD) biomarkers. ROI analyses prior studies reported significant MTL structural differences cognitively normal individuals with and without ß‐amyloid (A+/‐CN). Pointwise analysis, offering spatial information neurodegeneration, has potential to pinpoint “signature regions” pathological change, but been underexplored MTL. This study...
Abstract Background Tau pathology and neurodegeneration in the medial temporal lobe (MTL) are highly associated Alzheimer’s Disease (AD). However, spatial pattern of neurodegeneration, contribution individual tau inclusion types, influence MTL co‐pathologies (i.e., TDP‐43) remain poorly understood. Traditional semi‐quantitative ratings or staging schemes capture limited variability severity provide no differentiation between types tangles, threads). We correlate quantitative measures from...
Abstract Background The medial temporal lobe (MTL) is the epicenter of both primary and concomitant molecular pathologies in Alzheimer’s disease (AD). intricate anatomy MTL has been subject extensive study over past two centuries. However, current PET MRI AD biomarkers use often crude parcellations that have not sufficiently validated vis‐à‐vis anatomical ground truth. Here we a unique dataset finely annotated serial histology, ex vivo antemortem 3T from 17 brain donors to train evaluate an...
Abstract Background The anterior portion of the medial temporal lobe (MTL) is one earliest regions showing tau deposition in Alzheimer’s disease (AD) and hence a key focus area for AD imaging biomarkers. However, anatomical variability MTL presents challenge segmentation protocols. Leveraging novel postmortem dataset with histology MRI, we aimed to develop histologically‐informed protocol entorhinal cortex (ERC), Brodmann Area (BA) 35 (approximates transentorhinal cortex), BA36 vivo 3 tesla...
Abstract Background It is assumed quantitative digital neuropathology methods will provide more information than semi‐quantitative ratings, but this presumption lacks formal assessment. Here, we compare quantitative, whole‐slide measurements of phosphorylated tau tangles and threads with pathology ratings. We evaluate whether additional prediction beyond Braak stage for variables associated pathology, examining the association in high stages age at death measures severity TDP‐43...
Abstract Background It is assumed quantitative digital neuropathology methods will provide more information than semi‐quantitative ratings, but this presumption lacks formal assessment. Here, we compare quantitative, whole‐slide measurements of phosphorylated tau tangles and threads with pathology ratings. We evaluate whether additional prediction beyond Braak stage for variables associated pathology, examining the association in high stages age at death measures severity TDP‐43...
The left ventricular dysfunction 36 (LVD-36) questionnaire is considered to be a tool assess the impact of ventricle impairment on patients' daily life. This methodological study was aimed translate and validity reliability Persian draft LVD-36 among Iranian heart failure (HF) patients.