A5086132743- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Noise Effects and Management
- Motor Control and Adaptation
- Doctoral Education Challenges and Solutions
- Multisensory perception and integration
- Neural and Behavioral Psychology Studies
- Perfectionism, Procrastination, Anxiety Studies
- Interdisciplinary Research and Collaboration
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- Delphi Technique in Research
- Neurological disorders and treatments
- Clinical Reasoning and Diagnostic Skills
- Speech and Audio Processing
- Artificial Intelligence in Healthcare
- Meta-analysis and systematic reviews
- Pain Management and Treatment
- Acoustic Wave Phenomena Research
Universität der Bundeswehr München
2022-2025
University of Regensburg
2019-2025
Czech Academy of Sciences, Institute of Psychology
2024
University Hospital Regensburg
2020-2022
Rhodes University
2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2021
The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced Sample Case History Questionnaire, a case history instrument for standardised collection information about characteristics patient. Since then, number studies been published which characterise individuals groups using data collected with this questionnaire....
Introduction: Chronic tinnitus is a condition estimated to affect 10-15% of the population. No treatment has shown efficacy in randomized clinical trials reliably and effectively suppress phantom perceptions, little known why patients react differently same treatments.Tinnitus heterogeneity may play central role response, but no study tried capture terms response.Research goals: To test if individualized response can be predicted using personal, characteristics. Methods: A survey conducted...
Tinnitus, the perception of sound in absence a corresponding sound, and distress caused by it, is rarely static phenomenon. It rather fluctuates over time depending on endogenous exogenous factors. The COVID-19 pandemic potential environmental stressor that might influence individually perceived tinnitus distress. Since not all people are affected same way, situation allows one to identify factors personality traits impact differently. In our study, 122 patients were included at two points:...
Objectives: Hearing aids (HAs) are a widely accepted first-line treatment option for individuals suffering from both hearing loss and chronic tinnitus. Though HAs highly effective at improving speech understanding, their effectiveness in ameliorating tinnitus symptoms is less clear. In recent years, several investigators have reported on attempts to predict using an array of variables. These included attributes (e.g., frequency, loudness, character), audiological characteristics degree...
Repetitive Transcranial magnetic stimulation (rTMS) is a non-invasive therapy for treatment-resistant disorders. Intermittent theta-burst (iTBS) has emerged as favorite treatment protocol the of resistant depression, with tendency to administer an increasing number pulses/session (p/s). We retrospectively analyzed records 215 in- and out-patients, suffering from unipolar or bipolar depressive disorder in German tertiary care hospital between January 2021 September 2024. All patients received...
The minimal clinically important difference (MCID) represents the smallest change in treatment outcome deemed meaningful. This study estimates MCID for 2 widely used tinnitus measures: Tinnitus Handicap Inventory (THI) and Functional Index (TFI), using anchor-based approaches while accounting baseline severity time interval. A multi-center randomized clinical trial. European centers. Anchor-based approaches, including effect size, receiver-operating characteristics, ΔTHI/TFI methods, were...
Abstract Tinnitus is defined as the perception of sound without an external source. Its perceptual suppression or on/off states remain poorly understood. This study investigates neural traits linked to brief acoustic tinnitus (BATS) using naive resting-state EEG (closed eyes) from 102 individuals. A set features (band power, entropy, aperiodic slope and offset spectrum, connectivity) standard classifiers were applied achieving consistent high accuracy across data splits: 98% for sensor 86%...
The aim of this study was to investigate the reliability low-frequency and high-frequency repetitive transcranial magnetic stimulation (rTMS) on healthy individuals over motor cortex. A secondary outcome assessment if rTMS results in inhibition facilitation.In experiment, 30 participants received four consecutive days one session each with application 1 Hz or 20 left were applied alternating order, whereby starting frequency randomized. Motor evoked potentials (MEPs) measured before after...
Despite the high frequency of tinnitus and its impact on wellbeing, little is known about economic burden, and, to our knowledge, no data are available out-of-pocket (OOP) expenses.
Abstract Background Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden many cases. Nevertheless, there is currently no general treatment or cure, presumable due to heterogeneity of tinnitus with its wide variety etiologies phenotypes. Hence, most studies merely demonstrated improvement subgroup patients. The majority are characterized small sample sizes, unstandardized treatments assessments, applications...
<b><i>Background:</i></b> The phenomenon of short-term tinnitus suppression by different forms acoustic stimulation is referred to as residual inhibition (RI). RI can be triggered in the majority cases and was found depending on used intensity, length or types sounds. Past research already stressed impact noise well superiority amplitude modulated (AM) pure tones at individual frequency for tonal tinnitus. Recently a novel approach determination noise-like...
Abstract Tinnitus is associated with a variety of aetiologies, phenotypes, and underlying pathophysiological mechanisms, available treatments have limited efficacy. A combination treatments, addressing various aspects tinnitus, might provide viable superior treatment strategy. In this international multicentre, parallel-arm, superiority, randomised controlled trial, patients chronic subjective tinnitus were recruited from five clinical sites across the EU as part interdisciplinary...
To investigate oscillatory brain activity changes following acoustic stimulation in tinnitus and whether these are associated with behavioral measures of loudness. Moreover, differences ongoing between individuals without residual inhibition (RI) examined (responders vs. non-responders). Three different types noise stimuli were administered for 45 patients. Subjects resting state was recorded before after via EEG alongside subjective measurements Delta, theta gamma band power increased,...
Tinnitus affects a considerable part of the population and develops into severe disorder in some sufferers. App-based interventions are able to provide low-threshold, cost-effective, location-independent care for tinnitus patients. Therefore, we developed smartphone app combining structured counseling with sound therapy conducted pilot study evaluate treatment compliance symptom improvement (trial registration: DRKS00030007). Outcome variables were Ecological Momentary Assessment (EMA)...
Tinnitus is an auditory phantom perception in the ears or head absence of a corresponding external stimulus. There currently no effective treatment available that reliably reduces tinnitus. Educational counseling approach aims to educate patients and inform them about possible coping strategies. For this feasibility study, we implemented educational material self-help advice smartphone app. Participants used app unsupervised during their daily routine over period four months. Comparing...
Abstract Tinnitus, characterized by the perception of sound without an external source, affects a significant portion population and can lead to considerable individual suffering, yet understanding its suppression remains limited. Understanding neural traits tinnitus may be crucial for developing accurate predictive models in research treatment. This study aims classify individuals capable brief acoustic (BATS; also known as residual inhibition) based on their independent resting state EEG...
Cognitive behavioral therapy (CBT) was shown to be effective in reducing tinnitus-related distress numerous controlled trials. Real-world data from tinnitus treatment centers are an important addition trials for demonstrating the ecological validity of results randomized Thus, we provided real-world 52 patients participating CBT group therapies during time period 2010 2019. The groups consisted five eight with typical content such as counseling, relaxation, cognitive restructuring, attention...
Abstract Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction tinnitus distress; however, little known about potentially increased effectiveness combination treatments and personalized each patient. Methods Within Unification Treatments Interventions Patients project, multicenter, randomized clinical trial conducted with aim to compare single combined on distress (UNITI-RCT). Five different centers...
Introduction Obsessive-compulsive disorder (OCD) affects 2–3% of the global population, causing distress in many functioning levels. Standard treatments only lead to a partial recovery, and about 10% patients remain treatment-resistant. Deep brain stimulation offers treatment option for severe, therapy-refractory OCD, with reported response 60%. We report comprehensive clinical, demographic, data who were treated DBS our institution. Methods offered severe chronic resistant OCD. Severity was...
Previous studies have shown a high prevalence of sleep disturbances in tinnitus patients. However, no study has yet evaluated subjective satisfaction. The present aimed to investigate associations self-reported satisfaction with sociodemographic factors, tinnitus-related distress, depression, and quality life. This is retrospective analysis 2344 outpatients presenting at tertiary German clinic from 2010 2020. Patients who filled five questionnaires (Tinnitus Handicap Inventory (THI),...