A5006047589- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Glaucoma and retinal disorders
- Migraine and Headache Studies
- Inflammasome and immune disorders
- Cerebral Venous Sinus Thrombosis
- Neuroscience of respiration and sleep
- Healthcare Systems and Technology
- Genomics and Rare Diseases
- RNA regulation and disease
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- S100 Proteins and Annexins
- Genetic Neurodegenerative Diseases
- Obstructive Sleep Apnea Research
- Pluripotent Stem Cells Research
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Noise Effects and Management
- Ocular Surface and Contact Lens
- Antioxidant Activity and Oxidative Stress
- Genetic factors in colorectal cancer
The University of Sydney
2023-2025
Instituto de Investigación Biosanitaria de Granada
2016-2025
Universidad de Granada
2016-2025
Centro de Investigación Biomédica en Red
2021-2025
Centre for Biomedical Network Research on Rare Diseases
2021-2025
Parque Tecnológico de la Salud
2021-2025
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2015-2024
Hospital Universitario Virgen de las Nieves
1997-2024
Spanish Oncology Genitourinary Group
2018-2023
Institute for Advanced Study
2021
This paper presents diagnostic criteria for Menière's disease jointly formulated by the Classification Committee of Bárány Society, The Japan Society Equilibrium Research, European Academy Otology and Neurotology (EAONO), American Otolaryngology-Head Neck Surgery (AAO-HNS) Korean Balance Society. classification includes two categories: definite probable disease. diagnosis is based on clinical requires observation an episodic vertigo syndrome associated with low- to medium-frequency...
This paper describes the diagnostic criteria for vestibular paroxysmia (VP) as defined by Classification Committee of Bárány Society. The diagnosis VP is mainly based on patient history and requires: A) at least ten attacks spontaneous spinning or non-spinning vertigo; B) duration less than 1 minute; C) stereotyped phenomenology in a particular patient; D) response to treatment with carbamazepine/oxcarbazepine; F) not better accounted another diagnosis. Probable follows: five 5 minutes;...
Familial Meniere's disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role FMD largely unknown. We retrieved exome sequencing data from 94 individuals 70 (MD) families. Through burden analysis, we calculated enrichment variants (allele frequency < 0.05) connexins genes compared with reference population. The monomer and homomeric connexon structural models were predicted...
Background Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes vertigo hearing loss and tinnitus. However, prevalence autoimmune diseases (AD) in patients MD has not been studied individuals uni or bilateral sensorineural (SNHL). Methods Findings We estimated AD 690 outpatients SNHL from otoneurology clinics at six tertiary referral hospitals using clinica criteria immune panel (lymphocyte populations,...
Objectives To define clinical subgroups by cluster analysis in patients with unilateral Meniere disease ( MD ) and to compare them the found bilateral . Design A cross‐sectional study a two‐step analysis. Settings tertiary referral multicenter study. Participants Nine hundred eighty‐eight adult Main outcome measures: best predictors potential different aetiologies. Results We established five clusters Group 1 is most frequently found, includes 53% of patients, it defined as sporadic, classic...
The aims of this study were to estimate the prevalence familial cases in patients with Meniere's disease (MD) and identify clinical differences between sporadic MD. We recruited 1375 definite MD according American Academy Otolaryngology-Head Neck Surgery criteria, obtaining history hearing loss or episodic vertigo by direct interview a postal survey 1245 multicenter study. Familial clustering was estimated recurrence risk ratio siblings (λs ) offspring (λo using intermediate high values for...
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, it depends on the duration disease. We have performed two-step cluster analysis in 398 patients MD (BMD) identify best predictors define subgroups potential different etiology improve phenotyping BMD...
Menière's disease and vestibular migraine (VM) are the most common causes of spontaneous recurrent vertigo. The current diagnostic criteria for two disorders mainly based on patients' symptoms, no biological marker is available. When applying these criteria, an overlap occasionally observed in clinical practice. Therefore, present prospective multicenter study aimed to identify accompanying symptoms that may help differentiate between MD, VM, probable (pVM). Two hundred sixty-eight patients...
Meniere's disease (MD) is a chronic disorder of the inner ear defined by sensorineural hearing loss, tinnitus and episodic vertigo, familial MD observed in 5–15% sporadic cases. Although its pathophysiology largely unknown, studies human temporal bones have found an accumulation endolymph scala media cochlea. By whole-exome sequencing, we identified two novel heterozygous single-nucleotide variants FAM136A DTNA genes, both Spanish family with three affected cases consecutive generations,...
Objective The aim of this work was to assess through a questionnaire the features vertiginous episodes, accompanying symptoms, familial history, and migraine precursors in sample 252 subjects with diagnosis definite vestibular migraine. Background Migraine is common neurological disorder characterized by episodic headaches specific features. About two‐thirds cases run families, patients may refer symptoms occurring infancy childhood, defined as syndromes that be associated vertigo, called...
Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap there is no biological marker to distinguish them. Two subgroups MD patients have been reported, according their IL-1β profile. Therefore, considering clinical similarity between VM MD, we aimed investigate cytokine profile means these patients. We also...
We present diagnostic criteria for motion sickness, visually induced sickness (VIMS), disorder (MSD), and VIMS (VIMSD) to be included in the International Classification of Vestibular Disorders. Motion are normal physiological responses that can elicited almost all people, but susceptibility severity high enough response considered a some cases. This report provides guidelines evaluating signs symptoms caused by physical or visual diagnosing an individual as having is severe constitute...
Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between and is lacking. Here, we investigate this relationship in a Swedish study. A total 3645 participants (1984 1661 without tinnitus) were enrolled via LifeGene, study from general population, aged 18-90 years, provided information on socio-demographic characteristics, as well presence its severity. Tinnitus severity self-reported or assessed using...
Genetic contributions to tinnitus have been difficult determine due the heterogeneity of condition and its broad etiology. Here, we evaluated genetic nongenetic influences on self-reported from Swedish Twin Registry (STR).Cross-sectional data STR was obtained. Casewise concordance rates (the risk one twin being affected given that his/her partner has tinnitus) were compared for monozygotic (MZ) dizygotic (DZ) pairs (N = 10,464 concordant discordant pairs) heritability coefficients proportion...
Epidemiological studies have found a higher prevalence of allergic symptoms and positive prick tests in patients with Meniere's disease (MD); however the effect allergenic extracts MD has not been established. Thus, this study aims to determine Aspergillus Penicillium stimulation cytokine release gene expression profile MD. Patients showed basal levels IL-1β, IL-1RA, IL-6 TNF-α when compared healthy controls. We observed that IL-1β had bimodal distribution suggesting two different subgroups...
Tinnitus is a common medical condition which interfaces many different disciplines, yet it not priority for any individual discipline. A change in its scientific understanding and clinical management requires shift toward multidisciplinary cooperation, only research but also training. The European School Interdisciplinary (ESIT) brings together unique consortium of practitioners, academic researchers, commercial partners, patient organizations, public health experts to conduct innovative...