A5035252898- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Ophthalmology and Eye Disorders
- Hearing Loss and Rehabilitation
- Glaucoma and retinal disorders
- Meningioma and schwannoma management
- Cerebral Venous Sinus Thrombosis
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Galician and Iberian cultural studies
- Spanish Linguistics and Language Studies
- Myasthenia Gravis and Thymoma
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Balance, Gait, and Falls Prevention
- Ocular Surface and Contact Lens
- Migraine and Headache Studies
- Head and Neck Anomalies
- Inflammasome and immune disorders
- Sinusitis and nasal conditions
- Cardiovascular Syncope and Autonomic Disorders
- Neurology and Historical Studies
- Hearing Impairment and Communication
Instituto de Investigación Biomédica de Salamanca
2015-2024
Universidad de Salamanca
2015-2024
Complejo Hospitalario de Salamanca
2015-2024
Hospital Clínico Universitario de Valencia
2007
Background Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes vertigo hearing loss and tinnitus. However, prevalence autoimmune diseases (AD) in patients MD has not been studied individuals uni or bilateral sensorineural (SNHL). Methods Findings We estimated AD 690 outpatients SNHL from otoneurology clinics at six tertiary referral hospitals using clinica criteria immune panel (lymphocyte populations,...
Objectives To define clinical subgroups by cluster analysis in patients with unilateral Meniere disease ( MD ) and to compare them the found bilateral . Design A cross‐sectional study a two‐step analysis. Settings tertiary referral multicenter study. Participants Nine hundred eighty‐eight adult Main outcome measures: best predictors potential different aetiologies. Results We established five clusters Group 1 is most frequently found, includes 53% of patients, it defined as sporadic, classic...
The aims of this study were to estimate the prevalence familial cases in patients with Meniere's disease (MD) and identify clinical differences between sporadic MD. We recruited 1375 definite MD according American Academy Otolaryngology-Head Neck Surgery criteria, obtaining history hearing loss or episodic vertigo by direct interview a postal survey 1245 multicenter study. Familial clustering was estimated recurrence risk ratio siblings (λs ) offspring (λo using intermediate high values for...
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, it depends on the duration disease. We have performed two-step cluster analysis in 398 patients MD (BMD) identify best predictors define subgroups potential different etiology improve phenotyping BMD...
The head impulse, nystagmus type, test of skew (HINTS) protocol set a new paradigm to differentiate peripheral vestibular disease from stroke in patients with acute syndrome (AVS). relationship between degree truncal ataxia and has not been systematically studied AVS. We group 114 who were admitted General Hospital due AVS, 72 them neuritis (based on positive abnormal caloric tests negative MRI), the rest Stroke: 32 PICA territory (positive HINTS findings, MRI) 10 AICA (variable findings...
Objective The aim of this work was to assess through a questionnaire the features vertiginous episodes, accompanying symptoms, familial history, and migraine precursors in sample 252 subjects with diagnosis definite vestibular migraine. Background Migraine is common neurological disorder characterized by episodic headaches specific features. About two‐thirds cases run families, patients may refer symptoms occurring infancy childhood, defined as syndromes that be associated vertigo, called...
Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap there is no biological marker to distinguish them. Two subgroups MD patients have been reported, according their IL-1β profile. Therefore, considering clinical similarity between VM MD, we aimed investigate cytokine profile means these patients. We also...
Epidemiological studies have found a higher prevalence of allergic symptoms and positive prick tests in patients with Meniere's disease (MD); however the effect allergenic extracts MD has not been established. Thus, this study aims to determine Aspergillus Penicillium stimulation cytokine release gene expression profile MD. Patients showed basal levels IL-1β, IL-1RA, IL-6 TNF-α when compared healthy controls. We observed that IL-1β had bimodal distribution suggesting two different subgroups...
Meniere's disease (MD) is a rare inner ear disorder characterized by sensorineural hearing loss, episodic vertigo, and tinnitus. Familial MD has been reported in 6 to 9% of sporadic cases, few genes including FAM136A, DTNA, PRKCB, SEMA3D, DPT have involved single families, suggesting genetic heterogeneity. In this study, the authors recruited 46 families with search for relevant candidate loss familial MD.Exome sequencing data from patients were analyzed variants case-control study. A total...
Benign paroxysmal positional vertigo (BPPV) is the most frequent peripheral in elderly. It a well-characterized entity and generally easy to treat.To evaluate main symptoms, time consult for problem, characteristics, treatment follow-up patients over 70 with BPPV.This was retrospective cohort study. Four hundred four were diagnosed have BPPV (between January 2006 December 2012); 211 of them ≥70 years old (mean 77.7 years) 193 <70 53.82 years).Patients took longer problem (Spearman rho, p =...
Conclusion: The developed software (HITCal) may be a useful tool in the analysis and measurement of saccadic video head impulse test (vHIT) responses with experience obtained during its use authors suggest that HITCal is an excellent method for enhanced exploration vHIT outputs. Objective: To develop (software) to analyze explore responses, mainly saccades. Methods: was written using computational development program; function access file programmed; extended tools were created automated...
Objective To evaluate vestibular function before and after cochlear implantation (CI) Study Design A prospective descriptive study. Material Methods: Thirty consecutive patients with profound sensorineural hearing loss undergoing CI. assessment of was performed the caloric test video head impulse (vHIT) in Dizziness Handicap Inventory (DHI) used for subjective Results received CI 21 by round window approach nine anteroinferior cochleostomy. Vestibular results were categorized into four...
Meniere's disease (MD) is a rare disorder characterized by episodic vertigo, sensorineural hearing loss, tinnitus and aural fullness. It associated with fluid imbalance between the secretion of endolymph in cochlear duct its reabsorption into subarachnoid space, leading to an accumulation inner ear. Epidemiological evidence, including familial aggregation, indicates genetic contribution consistent association autoimmune diseases. We conducted case-control study two phases using immune...
Meniere's Disease (MD) is a complex disorder associated with an accumulation of endolymph in the membranous labyrinth inner ear. It characterized by recurrent attacks spontaneous vertigo sensorineural hearing loss (SNHL) and tinnitus. The SNHL usually starts at low medium frequencies variable progression to high frequencies. We identified novel missense variant PRKCB gene Spanish family MD segregating low-to-middle frequency SNHL. Confocal imaging showed strong PKCB II protein labelling...
Meniere Disease (MD) is an inner ear syndrome, characterized by episodes of vertigo, tinnitus and fluctuating sensorineural hearing loss. The pathological mechanism leading to sporadic MD still poorly understood, however allergic inflammatory response seems be involved in some patients with MD.Decipher immune signature associated the syndrome.We performed mass cytometry profiling on peripheral blood from controls. We analyzed differences state abundance different cellular subsets. IgE levels...
Objectives/Hypothesis To evaluate the vestibulo‐ocular reflex and its relationship with subjective balance in a long‐term follow‐up after vestibular schwannoma surgery. Study Design Retrospective cohorts study tertiary referral hospital. Forty‐nine consecutive patients on which surgery was performed at least 1 year before. Methods Patients are classified accordance morphology of (VOR) into two groups: Group A, covert overt saccades always occur an organized fashion; group B, randomly during...
Systemic lupus erythematosus (SLE) is associated with several comorbidities, including hearing and vestibular disorders. We recently described an increase of SLE prevalence in patients Menierés disease (MD). The aim this study to explore if a subset may have common inner ear disorder determine the potential relationship migraine. METHODS; Eighty-nine (according American College Rheumatology criteria for diagnosis SLE) were evaluated audiovestibular symptoms by telephone interview carried out...
<ns4:p>Ménière’s disease (MD) represents a heterogeneous group of relatively rare disorders with three core symptoms: episodic vertigo, tinnitus, and sensorineural hearing loss involving 125 to 2,000 Hz frequencies. The majority cases are considered sporadic, although familial aggregation has been recognized in European Korean populations, the search for MD genes elusive until last few years. Detailed phenotyping cluster analyses have found several clinical predictors different subgroups...
Dizziness is a frequent complaint in patients with vestibular schwannoma (VS). An abnormal vestibulo-ocular reflex (VOR) can explain this dizziness VS. The video Head impulse test (vHIT) offers chance to describe specifically the VOR findings such patients.Retrospective cases series study tertiary referral hospital.Fifty consecutive VS were classified accordance morphology of VOR; gain, covert saccade, and overt saccade analyzed both affected side healthy side. For all patients, caloric...
Conclusion: VOR adaptation and organization of refixation saccades in a gathered pattern is process that can be artificially induced patients with unilateral vestibular loss who have not developed it naturally, improving imbalance disability.Objective: To test temporary grouping should linked to better clinical status without gain recovery.Methods: A training induce the into fashion performed. The outcome measures are handicap level measured by dizziness index (DHI) numeric score called ‘PR’...
Backgroundtinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus reported in 1% of the population and it shows relevant heritability, according to twins, adoptees familial aggregation studies. The genetic contribution unknown since large genomic studies include individuals self-reported heterogeneity phenotype. aim this study was identify genes for patients extreme phenotype.Methodsfor phenotype study, we used three different...