A5103735764- Virtual Reality Applications and Impacts
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Neurofibromatosis and Schwannoma Cases
- Visual perception and processing mechanisms
- Migraine and Headache Studies
- Neural and Behavioral Psychology Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Multisensory perception and integration
- Neuroscience of respiration and sleep
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Botulinum Toxin and Related Neurological Disorders
- Spatial Cognition and Navigation
- Meningioma and schwannoma management
- Memory and Neural Mechanisms
- Cerebral Venous Sinus Thrombosis
- Tactile and Sensory Interactions
- Behavioral Health and Interventions
- Trigeminal Neuralgia and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Pain Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
University of Westminster
2015-2024
Imperial College London
2006-2024
Université de Caen Normandie
2021
Centre Hospitalier Universitaire de Caen
2021
Charing Cross Hospital
2006-2020
University of Oxford
1982-2016
University of Cambridge
1988-2016
UNSW Sydney
2016
Addenbrooke's Hospital
1988-2016
King's College London
2016
Symptomatic recovery after acute vestibular neuritis (VN) is variable, with around 50% of patients reporting long term symptoms; hence, it essential to identify factors related poor clinical outcome. Here we investigated whether excessive reliance on visual input for spatial orientation (visual dependence) was associated symptoms following VN. Twenty-eight VN and 25 normal control subjects were included. Patients enrolled at least 6 months illness. Recovery status not a criterion study...
Several studies have suggested that anxiety may play a role in motion sickness susceptibility (MSS) variability. This study aimed to assess healthy subjects and chronic vestibular patients investigate its relationship gender, age trait-anxiety. Healthy (n=167) dizzy with various vestibulopathies (n=94), aged from 20 92 years old, were asked complete Motion Sickness Susceptibility questionnaire (MSSQ) trait-anxiety (STAI-B). When divided into those who had loss (n=51) vs. without (n=43), the...
Ménière's disease is characterised by severe vertigo attacks and hearing loss. Intratympanic gentamicin, the standard treatment for refractory disease, reduces vertigo, but damages vestibular function can worsen hearing. We aimed to assess whether intratympanic administration of corticosteroid methylprednisolone compared with gentamicin.In this double-blind comparative effectiveness trial, patients aged 18-70 years unilateral were enrolled at Charing Cross Hospital (London, UK) Leicester...
We present diagnostic criteria for motion sickness, visually induced sickness (VIMS), disorder (MSD), and VIMS (VIMSD) to be included in the International Classification of Vestibular Disorders. Motion are normal physiological responses that can elicited almost all people, but susceptibility severity high enough response considered a some cases. This report provides guidelines evaluating signs symptoms caused by physical or visual diagnosing an individual as having is severe constitute...
Background: The introduction of new visual technologies increases the risk visually induced motion sickness (VIMS). aim was to evaluate 6-item Visually Induced Motion Sickness Susceptibility Questionnaire (VIMSSQ; also known as VIMSSQ-short) and other predictors for individual susceptibility VIMS. Methods: Healthy participants (10M + 20F), mean age 22.9 (SD 5.0) years, viewed a 360° panoramic city scene projected in equivalent situation rotating about an axis tilted from vertical. rotated at...
Two studies were conducted to develop and validate a questionnaire estimate individual susceptibility visually induced motion sickness (VIMS).VIMS is common side-effect when watching dynamic visual content from various sources, such as virtual reality, movie theaters, or smartphones. A reliable predicting VIMS currently missing. The aim was fill this gap by introducing the Visually Induced Motion Sickness Susceptibility Questionnaire (VIMSSQ).A survey an experimental study conducted. Survey:...
Little is known about the vestibulo-perceptual (VP) system, particularly after a unilateral vestibular lesion. We investigated vestibulo-ocular (VO) and VP function in 25 patients with neuritis (VN) acutely (2 days onset) compensation (recovery phase, 10 weeks). Since effect of VN on reflex perceptual may differ at threshold supra-threshold acceleration levels, we used two stimulus intensities, steps 0.5°/s(2) velocity 90°/s (acceleration 180°/s(2)). hypothesised that lesion or compensatory...
Vestibular migraine is among the commonest causes of episodic vertigo. Chronically, patients with vestibular develop abnormal responsiveness to both and visual stimuli characterized by heightened self-motion sensitivity visually-induced dizziness. Yet, neural mechanisms mediating such symptoms remain unknown. We postulate that are attributable impaired visuo-vestibular cortical interactions, which in turn disrupts normal function. To assess this, we investigated whether prolonged, full-field...
Abstract Background NF2 patients develop multiple nervous system tumors including bilateral vestibular schwannomas (VS). The and their surgical treatment are associated with deafness, neurological disability, mortality. Medical bevacizumab has been reported to reduce VS growth improve hearing. In addition evaluating these effects, this study also aimed determine other important consequences of patient-reported quality life the impact on rates. Methods Patients treated underwent serial...
The widespread use of visual technologies such as Virtual Reality increases the risk visually induced motion sickness (VIMS). Previously, 6-item short version Visually Induced Motion Sickness Susceptibility Questionnaire (VIMSSQ form) has been validated for predicting individual variation in VIMS. aim current study was to investigate how susceptibility VIMS is correlated with other relevant factors general population. A total 440 participants (201 M, 239F), mean age 33.6 (SD 14.8) years,...
Neurofibromatosis 1 (NF1) is an inherited, multi-system, tumour suppressor disorder with variable complications that cause psychological distress and social isolation. The study aim was to develop validate a disease-specific questionnaire measure quality of life (QOL) in NF1 suitable both as assessment tool clinical practice trials novel therapy. Impact on Quality Life (INF1-QOL) developed by literature search for common terms, focus group (n = 6), semi-structured interviews 21), initial...
Aims Hyoscine (scopolamine), which is effective in the prophylaxis of motion sickness, shows similar binding affinities to all five known muscarinic receptor sub‐types. The effectiveness hyoscine was compared with zamifenacin (UK‐76654), binds selectively M 3 and m5 receptors. Methods Eighteen subjects received hydrobromide 0.6 mg, 20 or placebo (double‐blind cross‐over design). Sessions were 1 week apart drug (oral) given 90 min prior a sickness test. Motion elicited by cross‐coupled...