A5087372330- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Nerve injury and regeneration
- Noise Effects and Management
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- RNA regulation and disease
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Acoustic Wave Phenomena Research
- Antimicrobial Peptides and Activities
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Music Perception
- Educational Innovations and Technology
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Multisensory perception and integration
- Chemokine receptors and signaling
- Blood disorders and treatments
- Neural Networks and Applications
University of Tübingen
2013-2024
TH Bingen University of Applied Sciences
2012
Max Planck Institute for Brain Research
1998
Illinois College
1996
University of Illinois Chicago
1996
Tinnitus is proposed to be caused by decreased central input from the cochlea, followed increased spontaneous and evoked subcortical activity that interpreted as compensation for responsiveness of auditory circuits. We compared equally noise exposed rats separated into groups with without tinnitus differences in brain relative degree deafferentation periphery. analyzed (1) number CtBP2/RIBEYE-positive particles ribbon synapses inner hair cell (IHC) a measure deafferentation; (2) fine...
The precision of sound information transmitted to the brain depends on transfer characteristics inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. We found that derived neurotrophic factor (BDNF) differentially influences IHC in intact injured cochlea. Using conditional knock-out mice (BDNF(Pax2) KO) we resting membrane potentials, capacitance linear leak conductance adult BDNF(Pax2) KO IHCs showed a normal maturation. Likewise, (ΔC(m)) as function inward...
Background: Accumulating evidence suggests that tinnitus may occur despite normal auditory sensitivity, probably linked to partial degeneration of the cochlear nerve and damage inner hair cell (IHC) synapse. Damage IHC synapses deafferentation even after moderate noise exposure. For both salicylate- noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) receptor activation related excitation have been suggested as origin tinnitus. Accordingly, NMDA inhibition has proposed a...
Spread of antimicrobial resistance and shortage novel antibiotics have led to an urgent need for new antibacterials. Although aminoglycoside (AGs) are very potent anti-infectives, their use is largely restricted due serious side-effects, mainly nephrotoxicity ototoxicity. We evaluated the ototoxicity various AGs selected from a larger set on basis strong antibacterial activities against multidrug-resistant clinical isolates ESKAPE panel: gentamicin, gentamicin C1a, apramycin, paromomycin...
Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory activity is associated with numerous forms of hearing loss, including noise damage, age-dependent and deafness, as well tinnitus or processing deficits autism spectrum disorder (ASD). In most cases, accompanying are interpreted an active compensatory response absence synaptic activity, increased neural gain control (increased output relative input). We here suggest that also could be related immaturity...
From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency pre-hearing murine cochleae pointed a role of Gαi3 for asymmetric migration the kinocilium as well orientation shape stereociliary ("hair") bundle, requirement progression mature hearing. We found lack impairs elongation hair bundle high-frequency cochlear regions,...
Background: It is assumed that speech comprehension deficits in background noise are caused by age-related or acquired hearing loss. Methods: We examined young, middle-aged, and older individuals with without threshold loss using pure-tone (PT) audiometry, short-pulsed distortion-product otoacoustic emissions (pDPOAEs), auditory brainstem responses (ABRs), steady-state (ASSRs), (OLSA), syllable discrimination quiet noise. Results: A noticeable decline of sensitivity extended high-frequency...
For all sensory organs, the establishment of spatial and temporal cortical resolution is assumed to be initiated by first experience a BDNF-dependent increase in intracortical inhibition. To address potential BDNF for sound processing, we used mice with conditional deletion which Cre expression was under control Pax2 or TrkC promoter. profiles between these differ organ Corti (BDNF -KO) versus auditory cortex hippocampus -KO). We demonstrate that -KO but not exhibit reduced sound-evoked...
Systemic corticosteroids have been the mainstay of treatment for various hearing disorders more than 30 yr. Accordingly, numerous studies described glucocorticoids (GCs) and stressors to be protective in auditory organ against damage associated with a variety health conditions, including noise exposure. Conversely, are also predictive risk factors disorders. How both these contrasting stress actions linked has remained elusive. Here, we demonstrate that higher corticosterone levels during...
Tinnitus is a phantom auditory perception, which can be induced via application of concentrated sodium salicylate, and known to associated with hearing loss altered neuronal excitability in peripheral central neurons. The molecular features this excitability, however, has been poorly characterized date. Brain-derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1, also as Arc), c-Fos are affected by changes plasticity. Using reverse transcription-polymerase...
Although tinnitus represents a major global burden, no causal therapy has yet been established. Ongoing controversies about the neuronal pathophysiology of hamper efforts in developing advanced therapies. Hypothesizing that unnoticed co-occurrence hyperacusis and differences duration may possibly differentially influence neural correlate tinnitus, we analyzed 33 patients without (T-group) 20 with (TH-group). We found crucial between T-group TH-group increase annoyance, complaints, loudness,...
Activity-dependent BDNF (brain-derived neurotrophic factor) expression is hypothesized to be a cue for the context-specificity of memory formation. So far, activity-dependent cannot explicitly monitored independently basal levels. We used BLEV ( B DNF- live-exon- visualization) reporter mouse specifically detect usage Bdnf exon-IV and -VI promoters through bi-cistronic co-expression CFP YFP, respectively. Enriching acoustic stimuli led improved peripheral central auditory brainstem...
1. Substance P (SP) induces a slow neuronal excitation in cholinergic neurons from the nucleus basalis by suppressing an inwardly rectifying K+ current (Kir). We have determined which G protein alpha-subunit mediates this SP effect. 2. After intracellularly injecting antibody against each of proteins (Gq alpha/11 alpha, G12 and G13 alpha) with Eppendorf microinjector, we examined, using whole cell patch-clamp ON-cell mode single-channel recording, effect on Kir cultured basalis. The was...
Brain-derived neurotrophic factor (BDNF) is a key neurotrophin whose expression altered in response to neurological activity, influencing both short- and long-term synaptic changes. The BDNF gene consists of eight upstream exons (I-VII), each which has distinct promoter can be independently spliced the ninth coding exon (IX). We showed recently that IV cochlea after exposure salicylate, an ototoxic drug high doses able induce hearing loss tinnitus. These changes were crucial trigger for...
Voltage-gated L-type Ca(2+) channels (L-VGCCs) like CaV1.2 are assumed to play a crucial role for controlling release of trophic peptides including brain-derived neurotrophic factor (BDNF). In the inner ear adult mouse, besides well-described L-VGCC CaV1.3, is also expressed. Due lethality constitutive knock-out mice, function this ion channel as well its putative relationship BDNF in auditory system entirely elusive. We recently described that plays differential hair cell (IHC) vesicles...
The ongoing controversies about the neural basis of tinnitus, whether linked with central gain or not, may hamper efforts to develop therapies. We asked what extent measurable audiometric characteristics tinnitus without (T) co-occurrence hyperacusis (TH) are distinguishable on level cortical responses. To accomplish this, electroencephalography (EEG) and concurrent functional near-infrared spectroscopy (fNIRS) were measured while patients performed an attentionally demanding auditory...
Impairments in working memory (WM) are a core cognitive deficit schizophrenia. Recent models of deficits have emphasized the potential role neural synchrony as pathophysiological mechanism underlying impaired WM performance disorder, suggesting that maintenance well encoding information may be related to sustaining precisely timed synchronized activity patterns. In present paper, we will first summarise synchronous oscillatory for normal brain functioning. Then examine existing data on...
Inner hair cells (IHCs), the primary sensory receptors of mammalian cochlea, fire spontaneous Ca2+ action potentials before onset hearing. Although this firing activity is mainly sustained by a depolarizing L-type (CaV1.3) current (ICa), IHCs also transiently express large Na+ (INa). We aimed to investigate specific contribution INa potentials, nature channels carrying and whether biophysical properties differ between low- high-frequency IHCs. show that highly temperature-dependent activates...