A5026605297- Dietary Effects on Health
- Neurobiology and Insect Physiology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Animal Behavior and Reproduction
- Genetic Neurodegenerative Diseases
- Insect and Arachnid Ecology and Behavior
- Animal Vocal Communication and Behavior
- Adipose Tissue and Metabolism
- Amyotrophic Lateral Sclerosis Research
- CRISPR and Genetic Engineering
- Nerve injury and regeneration
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Hearing Loss and Rehabilitation
- Developmental Biology and Gene Regulation
- Acoustic Wave Phenomena Research
- Physiological and biochemical adaptations
- Insect Utilization and Effects
- Insect Resistance and Genetics
- Congenital heart defects research
Max Planck Institute for Biology of Ageing
2014-2022
University of Cologne
2004-2017
University of Göttingen
2009
Volkswagen Foundation
2004-2007
University of Bristol
2003-2004
Max Planck Institute for Developmental Biology
2004
University of Zurich
2003
Dipeptide repeat peptides on the attack Certain neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), are associated with expanded dipeptides translated from RNA transcripts of disease-associated genes (see Perspective by West and Gitler). Kwon et al. show that encoded repeats in C9orf72 gene interfere way cells make kill cells. These effects may account for how this genetic form ALS causes disease. Working Drosophila , Mizielinska aimed to distinguish between...
Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan diverse species, including rodents. However, the mechanisms by which DR interacts with process to improve old age are poorly understood. DNA methylation could play an important role mediating effects because it is sensitive nutrition can affect gene expression memory over time. Here, we profile genome-wide changes methylation, lipidomics response...
In insects and vertebrates alike, hearing is assisted by the motility of mechanosensory cells. Much like pushing a swing augments its swing, this cellular thought to actively augment vibrations inside ear, thus amplifying ear's mechanical input. Power gain hallmark such active amplification, yet whether how much energy motile cells contribute within intact auditory systems has remained uncertain. Here, we assess provided neurons in antennal organs Drosophila melanogaster analyzing...
Sleep fragmentation, particularly reduced and interrupted night sleep, impairs the quality of life older people. Strikingly similar declines in sleep are seen during ageing laboratory animals, including fruit fly Drosophila. We investigated whether activity nutrient- stress-sensing insulin/insulin-like growth factor (IIS)/TOR signalling network, which ameliorates diverse organisms, could rescue fragmentation Lowered IIS/TOR network improved quality, with increased day fragmentation. Reduced...
The decision to move towards a mating partner or food source is essential for life. mechanisms underlying these behaviors are not well understood. Here, we investigated the role of octopamine – invertebrate analogue noradrenaline in innate olfactory attraction ethanol. We confirmed that preference caused via an stimulus by dissecting function co-receptor Orco (formally known as OR83b). required ethanol recognition per se, however it plays context dependent Odor-evoked requires Tbh (Tyramine...
Prestin, the fifth member of anion transporter family SLC26, is outer hair cell molecular motor thought to be responsible for active mechanical amplification in mammalian cochlea. Active present a variety other auditory systems, yet prevailing view that prestin molecule unique ears. Here we identify prestin-related SLC26 proteins are expressed organs nonmammalian vertebrates and insects. Sequence comparisons revealed presence fish ( Danio , GenBank accession no. AY278118, Anguilla BAC16761),...
G4C2 repeat expansions within the C9orf72 gene are most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide proteins. Here, we show that insulin/IGF signalling is reduced in fly models expansion using RNA sequencing adult brain. We further demonstrate activation can mitigate multiple neurodegenerative phenotypes flies expressing either expanded or protein poly-GR....
Prestin, a member of the solute carrier (SLC) family SLC26A, is molecular motor that drives somatic electromotility mammalian outer hair cells (OHCs). Its closest reported homologue, zebrafish prestin (zprestin), shares approximately 70% strong amino acid sequence similarity with prestin, predicting an almost identical protein structure. Immunohistochemical analysis now shows zprestin expressed in ear. Similar to heterologously found generate voltage-dependent charge movements, giving rise...
Restriction of amino acids in the diet can extend lifespan diverse species ranging from flies to mammals. However, role individual and underlying molecular mechanisms are only partially understood. The evolutionarily conserved serine/threonine kinase General Control Nonderepressible 2 (GCN2) is a key sensor acid deficiency has been implicated response dietary restriction (DR). Here, we generated novel
Brain-derived neurotrophic factor (BDNF) is a key neurotrophin whose expression altered in response to neurological activity, influencing both short- and long-term synaptic changes. The BDNF gene consists of eight upstream exons (I-VII), each which has distinct promoter can be independently spliced the ninth coding exon (IX). We showed recently that IV cochlea after exposure salicylate, an ototoxic drug high doses able induce hearing loss tinnitus. These changes were crucial trigger for...
The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. To understand how changes neuronal function, we analyzed Hangover function on and level. We provide evidence acts as nuclear RNA binding protein identified the phosphodiesterase 4d ortholog dunce target RNA. generated transcript-specific mutant impaired not only but also response. At level, Dunce are same neuron pair to regulate experience-dependent motor output....
Abstract Dietary restriction (DR) during adulthood can greatly extend lifespan and improve metabolic health in diverse species. However, whether DR mammals is still effective when applied for the first time at old age remains elusive. Here, we conducted a late-life switch experiment employing 800 mice, by switching animals from ad libitum (AL) to vice versa. Strikingly, DR-to-AL acutely increased mortality, while AL-to-DR caused only weak gradual increase survival, highlighting memory of...