Goal-directed behavior requires the continuous monitoring and dynamic adjustment of ongoing actions. Here, we report a direct coupling between event-related electroencephalogram (EEG), functional magnetic resonance imaging (fMRI), behavioral measures performance in humans. By applying independent component analysis to EEG signals recorded simultaneously with fMRI, found single-trial error-related negativity be systematically related subsequent trial, thereby reflecting immediate adjustments...

The ability to hold multiple objects in memory is fundamental intelligent behavior, but its neural basis remains poorly understood. It has been suggested that items may be held by oscillatory activity across neuronal populations, yet there little direct evidence. Here, we show information about two short-term enhanced at specific phases of underlying population activity. We recorded from the prefrontal cortices monkeys remembering visual over a brief interval. found during this interval was...

Signal flow during sensorimotor choices Little is known about the of task signals across brain. Siegel et al. simultaneously recorded from multiple units in sensory, parietal, prefrontal, and motor cortex while monkeys were cued to perform one among two possible simple tasks. The proportion neurons coding for stimuli, cues, tasks, choices, their response latency, varied regions. Parietal prefrontal brain regions encoded information with same latency. Interestingly, all areas types...

Cognition has a severely limited capacity: Adult humans can retain only about four items "in mind". This limitation is fundamental to human brain function: Individual capacity highly correlated with intelligence measures and reduced in neuropsychiatric diseases. Although limitations are well studied, their mechanisms have not been investigated at the single-neuron level. Simultaneous recordings from monkey parietal frontal cortex revealed that visual occurred immediately upon stimulus...

EEG is the most common technique for studying neuronal dynamics of human brain. However, electromyogenic artifacts from cranial muscles and ocular executing involuntary microsaccades compromise estimates activity in gamma band (>30 Hz). Yet, relative contributions practical consequences these remain unclear. Here, we systematically dissected effects different on visual gamma-band with sensor source level, show strategies to cope confounds. We found that muscle prevented a direct...

REVIEW article Front. Hum. Neurosci., 28 February 2011Sec. Brain Imaging and Stimulation volume 5 - 2011 | https://doi.org/10.3389/fnhum.2011.00021

A person's ability to detect a weak visual target stimulus varies from one viewing the next. We tested whether trial-to-trial fluctuations of neural population activity in human brain are related behavioral performance "yes-no" motion-detection task. recorded with whole head magnetoencephalography (MEG) while subjects searched for coherent motion signal embedded spatiotemporal noise. found that, during viewing, MEG 12- 24-Hz ("beta") frequency range is higher, on average, before correct...

Coupling of neuronal oscillations may reflect and facilitate the communication between populations. Two primary coupling modes have been described: phase-coupling amplitude-coupling. Theoretically, both are independent, but so far, their relationship remains unclear. Here, we combined MEG, source-reconstruction simulations to systematically compare cortical amplitude-coupling patterns in human brain. Importantly, took into account a critical bias measures due phase-coupling. We found...

Many large-scale functional connectivity studies have emphasized the importance of communication through increased inter-region correlations during task states. In contrast, local circuit demonstrated that states primarily reduce among pairs neurons, likely enhancing their information coding by suppressing shared spontaneous activity. Here we sought to adjudicate between these conflicting perspectives, assessing whether co-active brain regions tend increase or decrease correlations. We found...

Abstract Our actions are constantly guided by decisions based on sensory information. The motor cortex is traditionally viewed as the final output stage in this process, merely executing responses these decisions. However, it not clear if, beyond role, itself impacts response selection. Here, we report activity fluctuations over measured using MEG, which unrelated to choice content and predict a visuomotor task seconds before made. These strongly influenced previous trial's tendency switch...

During the past decade, numerous studies have demonstrated stimulus-specific synchronization of neuronal activity in γ-frequency range. However, it appears that different analyses are based on widely assumptions about which frequency range to investigate. Therefore, term “γ-synchronization” refers an inhomogeneous spectrum definitions and corresponding bands. Moreover, most been performed anesthetized animals or awake by use fixation paradigms. Thus, is difficult relate these results alert...

A central goal in systems neuroscience is to understand how the brain encodes intensity of sensory features. We used whole-head magnetoencephalography investigate whether frequency-specific neuronal activity human visual cortex systematically modulated by an elementary feature such as motion. Visual stimulation induced a tonic increase at frequencies above 50 Hz. In order define functional frequency band activity, we parametrically investigated which displays strongest monotonic responses...