A5071815164- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Supramolecular Self-Assembly in Materials
- Water Systems and Optimization
- Receptor Mechanisms and Signaling
- interferon and immune responses
- Allergic Rhinitis and Sensitization
- Vagus Nerve Stimulation Research
- Dermatology and Skin Diseases
- Fire Detection and Safety Systems
- Nicotinic Acetylcholine Receptors Study
- Combustion and Detonation Processes
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- vaccines and immunoinformatics approaches
Tsinghua University
2019-2024
Center for Life Sciences
2021-2024
Peking University
2023-2024
Beijing Institute of Technology
2017
Significance Neuronal innervation in the adipose tissues plays a crucial role regulating thermogenic capacity and metabolic homeostasis. The tissue-wide nerves display large extent of structural plasticity under physiological pathological conditions that alter neuronal control states. We find here is regulated by immune cells, which constitutes an appealing way to reshape neural-controlled energy balance targeting components.
The nervous system can modulate the body's immunity. However, how efferent neural signals reach out to control local immunity remains incompletely understood. Here, we report ImmuView procedure for whole-tissue 3D assessment of innervations in intact immune organs adult mice. This advanced imaging technique revealed an intricate, panicle-shaped sympathetic architecture parenchyma spleen but not other organs, including lymph nodes, Peyer's patch, and thymus. In contrast, observed minimal...
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching. The colonization of Staphylococcus aureus (S. aureus) correlated with the severity disease, but its role AD development remains elusive. Using single-cell RNA sequencing, we uncovered that keratinocytes activate distinct immune response characterized by induction Il24 when exposed to methicillin-resistant S. (MRSA). Further experiments using animal...
Abstract New adjuvants that trigger cellular immune responses are urgently needed for the effective development of cancer and virus vaccines. Motivated by recent discoveries show activation type I interferon (IFN‐I) signaling boosts T cell immunity, this study proposes targeting pathway can be a strategic approach to identify novel vaccine adjuvants. Consequently, comprehensive chemical screening 6,800 small molecules is performed, which results in discovery natural compound picrasidine S...
Purpose The purpose of this paper is to present a new technique for monitoring gas leakage in underground pipelines prevent dangerous explosions. Design/methodology/approach A novel system methane concentration spaces was developed by integrating the multi-channeled air sampling method with an infrared sensor. pipe installation methodology (without excavation) established and verified accordingly. Findings proposed approach proven successful reducing quantity sensors needed real-time...