A5102891982- Renal and related cancers
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Air Quality and Health Impacts
- Genetic Syndromes and Imprinting
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- interferon and immune responses
- Urological Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Fungal Biology and Applications
- RNA regulation and disease
- Immune Response and Inflammation
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Hair Growth and Disorders
- Bioactive Compounds and Antitumor Agents
- Histone Deacetylase Inhibitors Research
- TGF-β signaling in diseases
- Congenital gastrointestinal and neural anomalies
- Kidney Stones and Urolithiasis Treatments
- Tea Polyphenols and Effects
China Pharmaceutical University
2013-2025
Coal Industry Jinan Design & Research Institute (China)
2024
Hangzhou Normal University
2013-2023
Capital Institute of Pediatrics
2020
Indiana University School of Medicine
2020
Nanjing Agricultural University
2013
Abstract Green tea, a water extract of non-fermented leaves Camellia sinensis L., is one the nonalcoholic beverages in China. It becoming increasingly popular worldwide, because its refreshing, mild stimulant and medicinal properties. Here we examined quorum sensing inhibitory potentials tea polyphenols (TP) as antivirulence compounds both vitro vivo . Biosensor assay data suggested minimum concentrations (MICs) TP against selected pathogens were 6.25 ~ 12.5 mg/mL. At sub-MIC, can...
To investigate the antitumor activity and action mechanism of fengycin using human lung cancer cell line 95D. The was tested in vitro vivo. Reactive oxygen species production, Ca(2+) uptake, mitochondrial membrane potential loss induced by 95D cells were measured flow cytometry a laser confocal microscope. Lactate dehydrogenase release caspase fengycin-treated assayed cytotoxicity detection kits. Apoptosis triggered identified 4,6-diamidino-2-phenylindole (DAPI) staining cytometry. effects...
Background/Objectives: In chronic hepatitis B infection (CHB), the surface antigen (HBsAg) continuously exhausts antibody (HBsAb), which leads to formation of immune tolerance. Accordingly, virus (HBV) can be blocked by inhibiting binding pre-S1/pre-S2 hepatocyte receptor NTCP, but clinical cure rate pre-S-based vaccines for CHB is limited. Methods: this study, we designed and prepared multivalent therapeutic mRNA encoding three proteins (L, M, S) at cell membrane, verified via in vitro...
Objectives: Lung cancer is one of the most prevalent cancers worldwide. Accurately determining lung subtypes and identifying high-risk patients are helpful for individualized treatment follow-up. Our study aimed to establish an effective model subtype classification overall survival (OS) prediction in with cancer. Methods: Histopathological images, clinical data, genetic information adenocarcinoma squamous cell carcinoma cases were downloaded from The Cancer Genome Atlas. An influencing...
Quorum sensing (QS) is a cell density dependent process that enables bacteria to communicate with each other based on the production, secretion and of auto-inducer molecules then subsequently regulate virulence associated gene expression. Interrupting quorum may represent novel alternative approach combat bacterial pathogen. Several can produce quenching (QQ) enzymes. However, role QQ in shaping microbiota level N-acyl-homoserine lactones (AHLs, prevalent type QS molecules) producing remains...
Microglia activation is a crucial event in neurodegenerative disease. The depression of microglial inflammatory response considered promising therapeutic strategy. NFκB signaling, including IKK/IκB phosphotylation, p65 nucelus relocalization and NFκB-related genes transcription are prevalent accepted to play important role activation. (+)-JQ1, BRD4 inhibitor firstly discovered as an anti-tumor agent, was later confirmed be anti-inflammatory compound. However, its effect microglia central...
Background The suppression of chimeric antigen receptor (CAR) T cells by the tumor microenvironment (TME) is a crucial obstacle in T-cell-based treatment solid tumors. Extra domain B (EDB)-fibronectin an oncofetal expressed on endothelium layer neovasculature and cancer cells. Though recognized as cell therapy target, engineered CAR thus far have failed to demonstrate satisfactory vivo efficacy. In this study, we report that targeting EDB-fibronectin redirected TCR-CAR (rTCR-CAR) bypasses...
Qian Yang Yu Yin Granule (QYYYG), a traditional Chinese herbal medicine, has been indicated for renal damage in hypertension decades China, but little remains known regarding its underlying molecular mechanism. Therefore, we performed the current study order to investigate mechanism of QYYYG treatment hypertensive damage. We hypothesize that relieves injury through an angiotensin II (Ang II)-nicotinamide adenine dinucleotide phosphate (NAPDH)-oxidase (NOX)-reactive oxygen species (ROS)...
Although no effective therapy is available to stop or reverse CKD progression targeting its key feature, the loss of peritubular capillaries (PTCs) leading interstitial fibrosis, myeloid-derived growth factor (MYDGF) with tissue-repairing activities enlightens therapeutic potential for CKD. However, extremely short circulatory lifetime (15 min) restricts application.We selected a tandem repeated (TR) region human CD164 as carrier fuse MYDGF and then investigated biophysical pharmacokinetic...
Tight junction proteins are correlated with cancer development. As the pivotal in epithelial cells, altered expression and distribution of different claudins have been reported a wide variety human malignancies. We previously that claudin-7 was strongly expressed benign bronchial cells at cell-cell while either discontinued weak or completely absent lung cancers. Based on these results, we continued working pattern its relationship herein proposed new Digital Image Classification,...
Fine particulate matter (PM2.5) in the atmosphere is easily accompanied by toxic and harmful substances, causing serious harm to human health, including cognitive impairment. Vitamin B12 (VitB12) an essential micronutrient that synthesized bacteria contributes neurotransmitter synthesis as a nutrition signaling molecule. However, relationship between VitB12 attenuation of impairment intestinal microbiota regulation PM2.5 exposure has not been elucidated. In this study, we demonstrated caused...
Abstract The coordination of restraining and priming antiviral signaling constitute a fundamental aspect immunological functions. However, we currently know little about the molecular events that can translate pathogenic cues into appropriate code for defense. Our present study reports specific role B cell lymphoma (Bcl)6 as checkpoint in initiation host response to cytosolic RNA viruses. Remarkably, Bcl6 specifically binds interferon-regulatory factor (IRF)7 loci restrains its...
The direct sequencing of the Kit cDNA obtained from mutant mice was used to reveal molecular nature W(-3Bao) ENU-induced mutation. There a T A transversion at 441st nucleotide in open reading frame (ORF), which introduced pre-mature termination codon residue 147. gross embryonic development, hematopoiesis and spermatogenesis were examined mice. no visible difference among W(-3Bao/+), W(-3Bao/3Bao) wild type embryos before day 12.5. appeared pale after E14.5 dwarf E16.5. An extremely low...