A5047137200- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Facial Nerve Paralysis Treatment and Research
- Dental Radiography and Imaging
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Cerebral Venous Sinus Thrombosis
- Sexual function and dysfunction studies
- Myasthenia Gravis and Thymoma
- Oral and Maxillofacial Pathology
- Endodontics and Root Canal Treatments
- Pain Mechanisms and Treatments
- Dental Implant Techniques and Outcomes
- Nuclear Structure and Function
- Trauma Management and Diagnosis
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Dermatological and COVID-19 studies
- Oropharyngeal Anatomy and Pathologies
- Cell death mechanisms and regulation
- Axon Guidance and Neuronal Signaling
- Medicinal Plants and Bioactive Compounds
- Obstructive Sleep Apnea Research
- Burn Injury Management and Outcomes
- Mitochondrial Function and Pathology
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
China Tobacco
2025
Beijing Academy of Science and Technology
2025
National Clinical Research Center for Digestive Diseases
2022-2024
National Clinical Research
2024
Second Affiliated Hospital of Zhejiang University
2007-2021
Health First
2020
October 6 University
2017-2018
First Affiliated Hospital of Jiamusi University
2018
Cordyceps sinensis, an entomogenous fungus with unique biological properties, has demonstrated significant anti-inflammatory potential. However, its effects on inflammation regulation need to be further investigated in detail. In this study, we aimed analyze the sinensis extract (CSE) obtained via ethanol extraction and assess regulation. The secretion of pro-inflammatory cytokines (IL-6, TNF-α, IL-8, IL-1β) level MMP9, Nrf2/HO-1 ROS were evaluated. A transwell system THP-1 BEAS-2B cells was...
Bone homeostasis is mediated by osteoblast-related bone formation and osteoclast-related resorption. The imbalance of due to excessive osteoclastogenesis or reduced osteogenesis can result in various disorders, such as postmenopausal osteoporosis (PMOP). receptor activator nuclear factor-κB ligand (RANKL)-induced factor kappa-light-chain-enhancer activated B cells (NF-κB) mitogen-activated protein kinase (MAPK) pathways are essential osteoclastogenesis. In this study, we aimed investigate...
Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by spontaneous and elicited paroxysms of electric-shock-like or stabbing in region the face. The epigenetic regulation TN still obscure. In current study, rat model subject to carbamazepine (CBZ) treatment was established, transcriptome- genome-scale profiling H3K9ac HDAC3 performed RNA-seq ChIP-seq. We observed that levels trigeminal ganglion were lower rats compared with those control, CBZ led recovery levels....
Repair strategies for injured peripheral nerve have achieved great progresses in recent years. However, the clinical outcomes remain unsatisfactory. Recent studies found that exosomes secreted by dental pulp stem cells (DPSC-exos) potential applications repair. In this study, we evaluated effects of human DPSC-exos on improving regeneration. Initially, established a coculture system between DPSCs and Schwann (SCs)
Clearing the somatotopic organization of trigeminal ganglion can help us to improve precision treatment for neuralgia. The distribution primary afferent perikarya 3 branches nerve in was investigated rabbit, and 3D model reconstructed then. After application wheat germ agglutinin-horseradish peroxidase DiI cut endings nerve, ophthalmic cells were found anteromedial part ganglion, mandibular posterolateral part, maxillary middle part. results suggest that rabbits is a mediolateral direction...
Background Microvascular decompression (MVD) has been the available method to cure trigeminal neuralgia (TN), and several factors have discussed as significant predictors of excellent outcome after MVD. Objective This study aimed find out value magnetic resonance tomographic angiography (MRTA) in predicting MVD for TNs. Method A total 157 cases TNs who underwent taken MRTA preoperatively postoperatively then were followed up 5 years. The possible prognostic analyzed by χ2 test Kaplan-Meier...
Purpose The aim of this study was to introduce our classification the neurovascular compression (NVC) in trigeminal neuralgia and radiologic indications for microvascular decompression (MVD) based on magnetic resonance tomographic angiography. Methods From 2003 2011, 322 patients with primary were treated MVD. score NVC from 0 3. Three scores, separately axial, oblique sagittal, coronal images, added together. degree classified as follows: grade (0–1), 1 (2–3), 2 (4–6), 3 (7–9). Results In...
Abstract Purpose Neurovascular compression (NVC) is hypothesized to be the main pathogenic factor of trigeminal neuralgia (TN). Microvascular decompression (MVD) has become a popular surgery for TN, and success rate depends on degree NVC. As routine examination before MVD, magnetic resonance tomographic angiography (MRTA) shows high sensitivity detecting However, there are no reports MRTA assessing Methods This study aimed evaluate determining NVC by comparing preoperative intraoperative...
Spontaneous pneumomediastinum (SPM), reported firstly by Hamman in 1939, is an uncommon, and usually benign, self-limiting clinical disorder found young people often without apparent precipitating factors or diseases. The predominant symptom of SPM the acute onset retrosternal chest pain. Because its low occurrence, mild intensity, diagnosis can be easily missed. We have reviewed our hospital records for past five years (about 100 000 in-hospital patients 90 emergency patients) only two...
The aim of this study was to investigate the protection inferior alveolar neurovascular bundle in bone operation conditions such as chronic osteomyelitis and cementoma.The enrolled 7 cases, 4 with 3 cementoma pain. Computed tomography scan 3-dimensional reconstruction were performed for diseases. Data processed by ProPlan CMF 1.3 software. edge lesion defined nerve marked. Template designed guide osteotomy line. Piezosurgery used osteotomy, avoidance canal. Current perception threshold (CPT)...
The authors introduce a new method to build three-dimensional (3D) model of the 3 branches trigeminal nerve in ganglion rabbit with different kinds fluorescence. Ten adult New Zealand rabbits both sexes weighing between 2.0 and 3.0 kg were used experiment. Then through an operation under general anesthesia, maxillary mandibular nerves exposed, red gold fluorescence applied investigate neurons nerves. Subsequently, DiI was as marker for ophthalmic neuron other side same rabbit. After...
Abstract Rationale: Alveolar soft part sarcoma (ASPS) is a very rare tissue sarcoma. ASPS often occurs in deep tissues of the lower extremities, and develops into metastatic diseases. Chemotherapy considered to be ineffective patients with ASPS, which constitutes important clinical challenge. The strategy for treatment still requires clarification order improve survival outcome. Patients concerns: A 19-year-old female patient presented 5-year history painless lump left knee 4-day cough. Her...
The injury of Schwann cells is an important pathological feature peripheral neuropathy. However, the explicit molecular mechanism and blocking method remains to be explored. In this study, we identified pivotal executor necroptosis-RIPK1, performed unique function in response oxidative stress-induced Rat cells. We found that after stress-simulation by H2O2, RIPK1 was activated independent genetic up-regulation, but through post-translational modification, including its protein levels,...
This study aimed to evaluate the relationship among pain region, branches of trigeminal nerve, and neurovascular compression (NVC) location. A total 123 consecutive patients with neuralgia (TN) underwent endoscope-assisted microvascular decompression according positive preoperative tomographic angiography. V2 alone was in 51 cases V3 64 cases. The location NVC classified into cranial, caudal, medial, or lateral sites. Some multiple regions were recorded as medial + caudal. Twenty-eight...