A5101668613- Peptidase Inhibition and Analysis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- Medical Research and Treatments
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Environmental Changes in China
- COVID-19 Clinical Research Studies
- Palliative Care and End-of-Life Issues
- Neuropeptides and Animal Physiology
- COVID-19 epidemiological studies
- Traditional Chinese Medicine Studies
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- Metalloenzymes and iron-sulfur proteins
- Remote-Sensing Image Classification
- Neurogenesis and neuroplasticity mechanisms
- Genomics, phytochemicals, and oxidative stress
- Ion Channels and Receptors
- Thermography and Photoacoustic Techniques
- Galectins and Cancer Biology
- Soil Carbon and Nitrogen Dynamics
- Renin-Angiotensin System Studies
- Cryospheric studies and observations
- SARS-CoV-2 detection and testing
Ningxia University
2022-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2023
Sun Yat-sen University
2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023
Shanxi Medical University
2021
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021
Xinxiang Medical University
2021
Shanghai University of Medicine and Health Sciences
2021
Second Military Medical University
2021
Shanxi University
2021
Rationale: PGC1α (peroxisome proliferator-activated receptor gamma coactivator 1α) represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate expression as a therapy, for instance, causing cardiomyopathy. Objective: To determine whether fine-tuning of is essential cardiac homeostasis in context-dependent manner. Methods Results: Moderate cardiac-specific overexpression through ROSA26 locus knock-in strategy was...
Fruits from several species of the Rosaceae family are reported to cause allergic reactions in certain populations. The allergens identified belong mainly four protein families: pathogenesis related 10 proteins, thaumatin-like lipid transfer proteins and profilins. These families putative allergen genes apple (Mal d 1 4) have been mapped on linkage maps subsequent genetic study allelic diversity hypoallergenic traits has carried out recently. In peach (Prunus persica), these gene denoted as...
The contribution of the fetus to inhibin production in human pregnancy is unclear. Previous studies have reported concentrations cord blood but on limited sample numbers. present study a more extensive examination sex differences immunoreactive and steroidal hormones term umbilical blood. Venous serum were found be significantly higher males (mean ± SD 2,168 914 pg/ml, n = 62) than females (1,761 951 63) (p < 0.01). Male total testosterone 0.005), free estradiol 0.05) also higher....
The development of isoproterenol- (ISO-) induced oxidative stress in the myocardium results myocardial necrosis. Sulforaphane (SFN-0.4% sulforaphane from standardized broccoli sprout extract) possesses chemoprotective, antidiabetic, and antibacterial activities is also active against cardiovascular-related problems due to its antioxidant properties. This study was designed investigate cardioprotective effect SFN isoproterenol-induced injury mice. Healthy male Swiss albino mice weighing 20–30...
In order to investigate the feasibility of using rice leaf critical nitrogen concentration as a nutrition diagnosis index, three-year positioning experiment with large-spike cultivar (Wuyoudao4) and multiple-spike (Songjing9) under five levels (0, 60, 120, 180, 240 kg·ha−1) was conducted. A dilution curve index (NNI) dry matter were constructed for Wuyoudao4 (Nc = 1.96LDM−0.56, R2 0.87, NNI between 0.6–1.26, Normalized Root Mean Square Error (n-RMSE) 13.07%) Songjing9 1.99LDM−0.44, 0.94,...
The increased sensitivity of the genomes uncoupled mutants to norflurazon indicates that they are probably deficient in plastid-to-nucleus signaling and unequivocally not resistant norflurazon.
Single-cell DNA sequencing (scDNA-seq) enables high-resolution profiling of genetic diversity among single cells and is especially useful for deciphering the intra-tumor heterogeneity evolutionary history tumor. Specific technical issues such as allele dropout, false-positive errors, doublets make scDNA-seq data incomplete error-prone, giving rise to a severe challenge accurately inferring clonal architecture To effectively address these issues, we introduce new computational method called...
Background/Aims: GATA4, a protein related to osteoblast differentiation and mineralization, whose acetylation is essential for cardiac defects. Here, we aimed explore the functional impacts of GATA4 on osteoporosis (OS). Methods: in hFOB1.19 293T cells was detected after exposure HDAC inhibitors (TSA SAHA). Co-immunoprecipitation conducted determine which HATs HDACs involved modulation acetylation/deacetylation, identify site. The transcriptional activity measured presence or absence...
In this paper, mathematical analysis of the global dynamics a viral infection model in vivo is carried out. Though originally to study hepatitis C virus (HCV) patients with high baseline loads or advanced liver disease, similar models still hold significance for other infection, such as B (HBV) human immunodeficiency (HIV) infection. By means Volterra-type Lyapunov functions, we know that basic reproduction number [Formula: see text] sharp threshold para-meter outcomes infections. If text],...
Abstract Background The Interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with Angiotensin converting enzyme (ACE2) on the host cells is a crucial step for viral entry and infection. Therefore, investigating molecular mechanism underlying interaction of great importance prevention infection SARS-CoV-2. In this study, we aimed to establish virus-free in vitro system study Results Our results show that ACE2-overexpressing HEK293T are captured by...
Accurate retrieval of ice surface temperature (IST) over the Arctic ice-water mixture zone (IWMZ) is significantly essential for monitoring change polar sea environment. Previous researchers have focused on evaluating accuracy IST in pack regions, possibly account availability situ measurement data. Few them assessed IWMZ. This study utilized Landsat 8/TIRS and Operation IceBridge observations (OIB) to evaluate current method IWMZ proposed an adjustment improving overall accuracy. An initial...
洞庭湖是中国第二大淡水湖,干湿季节水体波动幅度大、频率高。卫星高频观测洞庭湖水体变化对及时、准确地监测其水文动态变化具有重要意义。本研究利用Sentinel-1和Sentinel-2影像(10 m),在兼具高时频与空间分辨率条件下重建和分析2017年—2020年洞庭湖水域面积的精细时序信息。此外,本研究拟创建一种基于湖区部分清晰影像来重建全湖水域面积的方法。该方法利用湖区某个区块面积与Sentinel-1全幅影像提取的湖泊面积构建的统计拟合关系建立经验模型,从而得到更密集的洞庭湖水域面积时间序列。拟合结果显示,每个区块的面积与总面积呈显著正相关,平均<italic>R</italic><sup>2</sup>值为0.94。将2017年—2020年获取的119景Sentinel-1影像和38景Sentinel-2影像用于提取洞庭湖区块水体淹没范围,以重建整个湖区面积。结合Sentinel-1和Sentinel-2影像,平均每个月可获取的观测影像为6景,某些月内监测次数可达10次,时间间隔为3—6...
Abstract Background Diabetes mellitus (DM) is a major risk factor for coronary artery disease (CAD), and the complications of CAD are leading cause deaths among people with DM. Herein, this study aims to identify common genes pathways between diabetes myocardial infarction (MI) provide more clues related mechanism studies. Methods Differentially expressed (DEGs) were identified using cutoff (|log2(fold change)|>0.45 P value<0.05) by analysis online datasets (GSE9006 GSE48060) DM MI...
Abstract Background Accurately deciphering clonal copy number substructure can provide insights into the evolutionary mechanism of cancer, and clustering single-cell profiles has become an effective means to unmask intra-tumor heterogeneity (ITH). However, numbers inferred from DNA sequencing (scDNA-seq) data are error-prone due technically confounding factors such as amplification bias allele-dropout, this makes it difficult precisely identify ITH. Results We introduce a hybrid model called...
This paper investigates the dynamic behavior of a viral infection model with general contact rate between susceptible host cells and free virus particles. If basic reproduction number is less than unity, by LaSalle’s invariance principle, disease-free equilibrium globally asymptotically stable. greater then persists in endemic locally
In this paper, we formulate a virus dynamics model with the recruitment of immune responses, saturation effects and an intracellular time delay. With help uniform persistence theory Lyapunov method, show that global stability is totally determined by basic reproductive number $R_0$. Furthermore, analyze responses on infection numerical simulation. The results ignoring will result in overestimation severity viral infection.
Objective To investigate the changes in acetylation of histone spinal dorsal horn a rat model persistent postoperative pain. Methods Ninety-six male Sprague-Dawley rats, weighing 200-250 g, aged 6-8 weeks, were randomly divided into 2 groups (n=48 each) using random number table: sham operation group (group S) and pain PPP). The evoked by skin/muscle incision retraction was established according to method described Flatters.After rats anesthetized with intraperitoneal chloral hydrate,...