A5100400457- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Anesthesia and Neurotoxicity Research
- Clostridium difficile and Clostridium perfringens research
- Cannabis and Cannabinoid Research
- Neonatal and fetal brain pathology
- Genetic Associations and Epidemiology
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Diet, Metabolism, and Disease
- Pharmacological Effects and Toxicity Studies
- Gut microbiota and health
- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
Xiangya Hospital Central South University
2020-2024
Central South University
2020-2024
Quzhou College of Technology
2017
Abstract Aim To investigate the potential causal relationship between non‐alcoholic fatty liver disease (NAFLD) and complications in type 1 diabetes (T1D) 2 (T2D). Materials Methods Two‐sample Mendelian randomization (MR) analysis was conducted to appraise after controlling for confounding factors. Genetic instrument variables NAFLD surrogated by chronically elevated serum alanine transferase were derived from a recent genome‐wide association study. Diabetes‐related complications, including...
This study aimed to comprehensively explore the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) its association with clinical information.
An increasing number of observational studies have revealed an association among the gut microbiota, metabolites, and epilepsy. However, this is easily influenced by confounders such as diet, causality remains obscure. Aiming to explore causal relationship ascertain specific microbe taxa for epilepsy, we conducted a bi-directional Mendelian randomization (MR) study based on genome-wide (GWAS) data epilepsy from International League Against Epilepsy, with microbiota GWAS results MiBioGen,...
Abstract Objective This work was undertaken to study the functional connectivity differences between non‐seizure‐free and seizure‐free patients with temporal lobe epilepsy (TLE) identify imaging predictors for drug responsiveness in TLE. Methods In this prospective study, 52 TLE who presented undetermined antiseizure medication 55 demographically matched healthy controls were sequentially recruited from Xiangya Hospital. Functional magnetic resonance data acquired during a Chinese version of...
Purpose: Patients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression deficits TLE patients. Defining a endophenotype for can provide information on impairment This study investigated by comparing neuropsychological function between patients TLE, their unaffected siblings, healthy control subjects. Methods: A total 46 26 33 subjects were...
To test a Chinese character version of the phonemic verbal fluency task in patients with temporal lobe epilepsy (TLE) and assess deficiency pattern TLE without hippocampal sclerosis, cross-sectional study was conducted including 30 sclerosis (TLE-HS), 28 (TLE-NHS), 29 demographically matched healthy controls (HC). Both sexes were enrolled. Participants finished (VFC) during functional MRI. The activation/deactivation maps, connectivity, degree centrality, community features left frontal...
Temporal lobe epilepsy is a neurological network disease in which genetics played greater role than previously appreciated. This study aimed to explore shared functional abnormalities patients with sporadic temporal and their unaffected siblings.Fifty-eight epilepsy, 13 siblings, 30 healthy controls participated this cross-sectional study. We examined the task-based whole-brain topology effective connectivity between networks identified by group-independent component analysis.We observed...
Cortical tremor/myoclonus is the hallmark feature of benign adult familial myoclonic epilepsy (BAFME), mechanism which remains elusive. A hypothesis that a defective control in preexisting cerebellar-motor loop drives cortical tremor. Meanwhile, basal ganglia system might also participate BAFME. This study aimed to discover structural basis BAFME.Nineteen patients with BAFME type 1 (BAFME1) and 30 matched healthy controls underwent T1-weighted diffusion tensor imaging scans. FreeSurfer...
Objective To explore the effect of thymosin alpha-1 (Ta1) on postnatal systemic inflammation-induced learning and memory impairment in mice their relevant mechanism. Methods (1) Twenty-four neonatal C57BL/6 were randomly assigned into normal saline group,lipopolysaccharide (LPS, 0.3 mg/kg) group, LPS (0.6 (0.9 group. And animals intraperitoneally injected with different doses or equal volume for 5 days. The variations body weight, liver weight relative to tumor necrosis factor-α...