A5001883391University of Edinburgh
2021-2022
Roslin Institute
2021-2022
Scottish National Blood Transfusion Service
2022
Edinburgh College
2021
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion resulting from zoonotic transmission of bovine spongiform encephalopathy (BSE). Documented cases vCJD by blood transfusion necessitate on-going risk reduction measures to protect supplies, such as leucodepletion (removal white cells, WBCs). This study set out determine the risks labile components (red platelets, plasma) commonly used in medicine, and effectiveness preventing infection, using BSE-infected sheep model. All were capable...
Abstract Infectious prion diseases have very long incubation periods, and the role that subclinical infections play in transmission, persistence re-emergence of these is unclear. In this study, we used a well-established model vCJD (sheep experimentally infected with bovine spongiform encephalopathy, BSE) to determine prevalence infection following exposure by blood transfusion from donors. Many recipient sheep survived for years post-transfusion no clinical signs disease-associated PrP (PrP...
Abstract Infectious prion diseases have very long incubation periods, and the role that subclinical infections play in transmission, persistence re-emergence of these is unclear. In this study, we used a well-established model vCJD (sheep experimentally infected with bovine spongiform encephalopathy, BSE) to determine prevalence infection following exposure by blood transfusion from donors. Many recipient sheep survived for years post-transfusion no clinical signs disease-associated PrP (PrP...