A5044232602- Infectious Diseases and Mycology
- Actinomycetales infections and treatment
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Virus-based gene therapy research
- Myxozoan Parasites in Aquatic Species
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Chromosomal and Genetic Variations
- HIV Research and Treatment
- Animal Virus Infections Studies
- Salivary Gland Disorders and Functions
- Animal Genetics and Reproduction
- Nuclear physics research studies
- Herpesvirus Infections and Treatments
- CRISPR and Genetic Engineering
- High-Energy Particle Collisions Research
- Quantum, superfluid, helium dynamics
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- High-Velocity Impact and Material Behavior
- Advanced NMR Techniques and Applications
Moredun Research Institute
2011-2025
Edinburgh Royal Infirmary
2015-2024
Roslin Institute
2024
University of Edinburgh
2024
Swansea University
2018
Great Western Hospital
2010
Virginia Tech
2008
University College London
1955-2003
Institute of Medical Sciences
2000-2002
Reed College
1980-2001
We review the theory of wave propagation in one dimension through a medium consisting N identical “cells.” Surprisingly, exact closed-form results can be obtained for arbitrary N. Examples include vibration weighted strings, acoustics corrugated tubes, optics photonic crystals, and, course, electron functions quantum solids. As increases, band structure characteristic waves infinite periodic media emerges.
ABSTRACT In view of the concern over potential infection hazards in use porcine tissues and organs for xenotransplantation to humans, we investigated diversity endogenous retrovirus (PERV) genomes DNA domestic pigs related species. addition three known envelope subgroups infectious gamma retroviruses (PERV-A, -B, -C), classed together here as PERV group γ1, four novel groups (γ2 γ5) beta (β1 β4) were detected pig using generic specific PCR primers. quantification indicated that retroviral...
ABSTRACT Endogenous betaretroviruses (enJSRVs) of sheep are expressed abundantly in the female reproductive tract and play a crucial role conceptus development placental morphogenesis. Interestingly, colonization genome by enJSRVs is likely still ongoing. During early pregnancy, enJSRV expression correlates with production tau interferon (IFNT), type I IFN, developing conceptus. IFNT pregnancy recognition signal ruminants possesses potent antiviral activity. In this study, we show that...
The results presented in this paper were obtained from an analysis of ${K}^{\ensuremath{-}}p$ interactions the 30-in. hydrogen bubble chamber at Argonne ZGS using incident ${K}^{\ensuremath{-}}$ beams momenta 4.1 and 5.5 GeV/c. $\overline{K}\ensuremath{\pi}N$ final states studied extensively; most prominent feature these is production ${K}^{*}(890)$ ${K}^{*}(1400)$ resonances. ${\overline{K}}^{0}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}n$ state was used to measure branching...
The polyether toxin, okadaic acid, causes diarrhetic shellfish poisoning in humans. Despite extensive research into its cellular targets using rodent models, we know little about putative effect(s) on innate immunity. We inoculated larvae of the greater wax moth, Galleria mellonella, with physiologically relevant doses acid by direct injection haemocoel (body cavity) and/or gavage (force-feeding). monitored larval survival and employed a range biochemical assays to assess potential harmful...
Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development improved vaccines therapeutics. Pigs increasingly recognized as valuable human due to their genetic, anatomical, physiological, immunological similarities humans, they present a more ethically viable alternative non-human primates. However, pigs not susceptible SARS-CoV-2 infection which limits utility model. To address this, we have developed transgenic expressing ACE2...
Different regions of the small ruminant lung exhibit variable susceptibility to specific pathologies. Such may be reflected in regional radiomic features extracted from computed tomography (CT) images. In this study, we investigated whether region-specific variation exists ovine lungs and these remain stable over time. Thoracic CT image datasets 30 young adult sheep were subject an segmentation protocol directed at partitioning into individual lobar sub-lobar segments for feature analysis....
A 932-bp retrovirus sequence was cloned by reverse transcriptase PCR from salivary gland tissue of a patient with Sjögren's syndrome. The is related to that type B and D retroviruses present in sucrose density gradient fraction corresponding an enveloped particle. Sequences amplified tissues eight individuals or without syndrome had over 90% similarity were at level less than one copy per 10(3) cells. not detectable human genomic DNA Southern hybridization. These data indicate the represents...
One-dimensional scattering from a series of delta-function barriers is considered, in the context nonrelativistic quantum mechanics. A surprisingly simple closed-form expression for transmission probability obtained, and compared with earlier result Kiang [Am. J. Phys. 42, 785–787 (1974)]. The band structure characteristic periodic potentials emerges even when number quite small. However, ‘‘saturation’’ phenomenon identified by Lee, Zysnarski, Kerr 57, 729–734 (1989)] found to depend on...
SUMMARY A number of studies have found increased levels antibodies to human endogenous retroviruses (HERVs) in autoimmune rheumatic diseases. It is not clear whether this immune response driven by the HERV itself or cross-reactions with an exogenous virus autoantigen. To address question, we examined antibody Env protein two closely related members HERV-K family, HERV-K10 and IDDMK1,222. By immunoblotting recombinant proteins, were 32–47% 84 sera from patients disease, 29% 35 normal...
A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into host cell genome. Reconstitution the from maedi-visna virus (MVV), an ovine lentivirus, revealed large assembly containing sixteen IN subunits1. Herein, we report cryo-EM structures lentiviral prior to engagement target and following strand transfer, refined at 3.4 3.5 Å resolution, respectively. The elucidate details protein-protein protein-DNA interfaces...
Animal models of human disease are important tools in many areas biomedicine; for example, infectious research and the development novel drugs medical devices. Most studies involving animals use rodents, particular congenic mice, due to availability a wide number strains ease with which they can be genetically manipulated. The mouse has led major advances fields research, immunology but despite these advances, no animal model exactly reproduce all features disease. It is increasingly...
Objective To examine whether human retrovirus 5 (HRV-5) infection is associated with autoimmune rheumatic disease. Methods DNA from patients various disorders including inflammatory diseases and normal subjects was tested by nested polymerase chain reaction (PCR) for HRV-5 proviral DNA. Positive results were confirmed sequencing. Results detected in 53% of synovial samples arthritic joints, 12% blood rheumatoid arthritis (RA), 16% systemic lupus erythematosus. In contrast, it not detectable...