A5016819400- Reproductive tract infections research
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Animal Disease Management and Epidemiology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Vector-Borne Animal Diseases
- Virus-based gene therapy research
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Ectopic Pregnancy Diagnosis and Management
- Gestational Trophoblastic Disease Studies
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Reproductive Health and Contraception
- Rabies epidemiology and control
- Aquaculture disease management and microbiota
- Urinary Tract Infections Management
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
Moredun Research Institute
2015-2025
University of Edinburgh
2010-2022
Roslin Institute
2010-2022
Palo Alto Institute
2010
Organic Research Centre
2009
The Pirbright Institute
2009
Vitenparken
2002-2008
Biomathematics and Statistics Scotland
2005
Background Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in non-pregnant and only becomes evident during subsequent pregnancy. Often first sign that an infected abortion occurring late gestation. Despite this, little understood underlying mechanisms control latency or recrudescence occurs The aim this study was to develop experimental model by mimicking natural route through intranasal inoculation sheep with C. abortus....
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression prokineticin receptors 1 2 (PROKR1 PROKR2); increases FT PROKR1, resulting in a microenvironment predisposed to EP. We hypothesize that C. also predisposes by altering PROKR have investigated this examining NFκB activation via ligation Toll-like receptor (TLR)...
Circulating monocytes in several mammalian species can be subdivided into functionally distinct subpopulations based on differential expression of surface molecules. We confirm that bovine express CD172a and MHC class II with two populations CD14+CD16low/-CD163+ CD14−CD16++CD163low- cells, a more diffuse population CD14+CD16+CD163+ cells. In contrast, ovine consisted only major CD14+CD16+ subset very low percentage CD14−CD16++cells. The subsets expressed similar levels CD80, CD40 CD11c...
Arboviruses cause acute diseases that increasingly affect global health. We used bluetongue virus (BTV) and its natural sheep host to reveal a previously uncharacterized mechanism by an arbovirus manipulate immunity. Our study shows BTV, similarly other antigens delivered through the skin, is transported rapidly via lymph peripheral nodes. Here, BTV infects disrupts follicular dendritic cells, hindering B-cell division in germinal centers, which results delayed production of high affinity...
Background/Objective: Chlamydia abortus, the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one most infectious causes foetal death in sheep worldwide. Although disease can be controlled using commercial inactivated live whole-organism vaccines, there are issues with both, particularly concerning efficacy safety. Recently, we have described development new COMC (chlamydial outer membrane complex) vaccine based on detergent-extracted protein preparation pathogen, which...
Expression of secretory leukocyte protease inhibitor
Skin infection studies are often limited by financial and ethical constraints, alternatives, such as monolayer cell culture, do not reflect many cellular processes limiting their application. For a more functional replacement, 3D skin culture models offer advantages the maintenance of tissue structure types present in host environment. A model can be set up using tissues acquired from surgical by-products or ex vivo, making it cost effective attractive alternative to animal experimentation....
Animal models of human disease are important tools in many areas biomedicine; for example, infectious research and the development novel drugs medical devices. Most studies involving animals use rodents, particular congenic mice, due to availability a wide number strains ease with which they can be genetically manipulated. The mouse has led major advances fields research, immunology but despite these advances, no animal model exactly reproduce all features disease. It is increasingly...
During the 2013–2016 Ebola outbreak in West Africa an expert panel was established on instructions of UK Prime Minister to identify priority pathogens for diseases that had potential cause future epidemics. A total 13 were identified, which led prioritisation spending emerging vaccine research and development from UK. This meeting report summarises process used develop pathogen list, compares it lists generated by other organisations (World Health Organisation, National Institutes Allergy...