A5069906618- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Renal and related cancers
- Immune cells in cancer
- Testicular diseases and treatments
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Gestational Trophoblastic Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Fatty Acid Research and Health
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Health Promotion and Cardiovascular Prevention
- Ectopic Pregnancy Diagnosis and Management
- Prenatal Screening and Diagnostics
- Reproductive Physiology in Livestock
- Pluripotent Stem Cells Research
- Peroxisome Proliferator-Activated Receptors
- 3D Printing in Biomedical Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diabetes Management and Research
Karolinska University Hospital
2019-2021
Karolinska Institutet
2019-2021
University of Baltimore
2021
Trinity College Dublin
2010-2011
MRC Centre for Reproductive Health
2011
The Queen's Medical Research Institute
2011
Medical Research Council
2011
University of Edinburgh
2010-2011
University College Dublin
2008-2011
Queen's Medical Centre
2010
High-fat diet (HFD)-induced adipose tissue inflammation is a critical feature of diet-induced insulin resistance (IR); however, the contribution interleukin-1 receptor I (IL-1RI)-mediated signals to this phenotype has not been defined. We hypothesized that lack IL-1RI may ameliorate HFD-induced IR by attenuating inflammation.Glucose homeostasis was monitored in chow- and HFD-fed wild-type (WT) IL-1RI(-/-) mice glucose tolerance tests. Macrophage recruitment cytokine signature macrophages...
One of the hallmarks polycystic ovary syndrome (PCOS) is increased ovarian androgen secretion that contributes to ovarian, hormonal, and metabolic features this condition. Thecal cells from women with PCOS have an enhanced capacity for synthesis. To investigate whether propensity a potential cause, rather than consequence, PCOS, we used ovine prenatal androgenization model assessed ewes at 11 months age. Pregnant Scottish Greyface were administered 100 mg testosterone propionate (TP) or...
Abstract Background Clinical studies indicate chemotherapy agents used in childhood cancer treatment regimens may impact future fertility. However, effects of individual on prepubertal human testis, necessary to identify later risk, have not been determined. The study aimed investigate the cisplatin, commonly cancer, immature (foetal and prepubertal) testicular tissues. Comparison was made with carboplatin, which is as an alternative cisplatin order reduce toxicity healthy Methods We...
Abstract Background Advances in three-dimensional culture technologies have led to progression systems used model the gonadal microenvironment vitro. Despite demonstrating basic functionality, tissue organisation is often limited. We previously detailed a termed three-layer gradient system generate rat testicular organoids Here we extend human first-trimester embryonic tissue. Results Testicular cell suspensions reorganised into testis-like with distinct seminiferous-like cords situated...
Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can be observed human cultures, germ cell depletion is a common obstacle. Hence, understanding spermatogonial stem (SSC) niche environment and particular, specific components seminiferous basement membrane (BM) will allow progression cultures. Here, we revealed that BM...
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Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
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An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.