A5061053776- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Obesity, Physical Activity, Diet
- Preterm Birth and Chorioamnionitis
- Neonatal and fetal brain pathology
- Grief, Bereavement, and Mental Health
- Cardiovascular Issues in Pregnancy
- Endometriosis Research and Treatment
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Obesity and Health Practices
- Fetal and Pediatric Neurological Disorders
- COVID-19 Impact on Reproduction
- Cardiac, Anesthesia and Surgical Outcomes
- Breastfeeding Practices and Influences
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Body Contouring and Surgery
University of Edinburgh
2014-2023
MRC Centre for Reproductive Health
2013-2022
Queen's Medical Centre
2013-2022
The Queen's Medical Research Institute
2007-2022
Medical Research Council
2008-2022
Leeds Teaching Hospitals NHS Trust
2020
University of Birmingham
2018
British Heart Foundation
2017
University of Florida
2011-2015
Tommy's
2015
Background Maternal obesity is associated with increased birthweight, and premature mortality in adult off spring.The mechanism by which maternal leads to these outcomes not well understood, but hyperglycaemia insulin resistance are both implicated.We aimed establish whether the sensitising drug metformin improves fetal obese pregnant women without diabetes. MethodsWe did this randomised, double-blind, placebo-controlled trial antenatal clinics at 15 National Health Service hospitals...
What care should be provided in the primary setting to women of childbearing age with obesity who wish become pregnant? Primary services ensure that all have opportunity optimise their weight before pregnancy. Advice on and lifestyle given during preconception counselling or contraceptive consultations. Weight BMI measured encourage Grade recommendation: ✓ Women a 30 kg/m2 greater receive information advice about risks pregnancy childbirth, supported lose conception between pregnancies line...
Objective To investigate the effect of maternal body mass index (BMI) on postdates pregnancy, length gestation and likelihood spontaneous onset labour at term. Design Retrospective cohort study. Setting Swedish Medical Birth Register. Population A total 186 087 primiparous women (of whom 143 519 had term) who gave birth between 1998 2002. Methods Mann–Whitney test, one‐way analysis variance, linear regression single variable logistic regression. Main outcome measures Postdates pregnancy...
Maternal obesity is associated with increased morbidity and mortality for both mother offspring. The mechanisms underlying the risk maternal are not well understood. In non-pregnant populations, many of complications thought to be mediated in part by inflammation its sequelae. Recent studies suggest that a heightened inflammatory response may also involved mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, role as...
Arterial stiffness and compliance are major predictors of adverse cardiovascular events influenced by female sex hormones, including estrogen progesterone. The aim this longitudinal study was to evaluate the effect menstrual cycle, normal pregnancy, preeclampsia on central systemic arterial stiffness. Ten healthy nulliparous women with regular menses were studied in early midfollicular, periovulatory, luteal phases a single cycle. Twenty-two primigravida pregnant throughout pregnancy at 16,...
To investigate the impact of maternal body mass index (BMI, kg/m(2)) on clinical complications, inpatient admissions, and additional short-term costs to National Health Service (NHS) in Scotland.Retrospective cohort study using an unselected population database.Obstetric units Scotland, 2003-2010.A total 124,280 singleton deliveries 109,592 women with a BMI recorded prior 16 weeks gestation.Population-based retrospective deliveries, multivariable analysis used assess morbidity health service...
The 14-3-3 proteins have emerged as major phosphoprotein interaction and thereby constitute a key node in the Arabidopsis Interactome Map, through which large number of important signals pass. Throughout their history discovery description, 14-3-3s been described protein families there has some evidence that different family members within any organism might carry isoform-specific functions. However, also for redundancy function, suggesting perceived diversity may be accumulation neutral...
The SARS-CoV-2 virus is primarily transmitted through virus-laden fluid particles ejected from the mouth of infected people. Face covers can mitigate risk transmission but their outward effectiveness not fully ascertained. Objective: by using a background oriented schlieren technique, we aim to investigate air flow person while quietly and heavily breathing, coughing, with different face covers. Results: found that all without an outlet valve reduce front at least 63% perhaps as high 86% if...
Cytokines such as monocyte chemotactic peptide-1 (MCP-1), interleukin-8 (IL-8), RANTES (Regulated on Activation and Normally T-cells Expressed presumably Secreted) interleukin-10 (IL-10) are thought to play pivotal roles in immune recognition, acceptance of the fetal allograft, maintenance pregnancy parturition. Their secretion regulation within third trimester uterus is, however, less well defined. We therefore investigated release these cytokines by amnion, chorion, placenta decidua,...
The State Trait Anxiety Inventory (STAI) has been widely used in research with pregnant women. However, few studies have examined its validity for this group. In paper the content of STAI, impact location and consequences further participation higher STAI scores are investigated 215 women who completed at hospital or community based clinics. study participants answered open ended question, ‘How do you feel about your pregnancy?’ whether not they would be willing to take part research....
Background Prenatal maternal obesity has been linked to adverse childhood neuropsychiatric outcomes, including increased symptoms of attention deficit hyperactivity disorder (ADHD), internalizing and externalizing problems, affective disorders neurodevelopmental problems but few studies have studied outcomes among offspring born very severely obese women or assessed potential familial confounding by psychological distress. Method We evaluated in 112 children aged 3–5 years whose mothers had...
Recruiting and consenting women to peripartum trials can be challenging as the concerned may anxious, in pain, exhausted; there also limited time for discussion decision-making occur. To address these potential difficulties, we undertook a qualitative evaluation of internal pilot trial (Got-it) involving who had retained placenta (RP). We explored experiences views staff about information consent pathway used within pilot, order provide recommendations use future recruitment emergency...
Human seminal plasma has potent anti-inflammatory properties which are thought to confer a survival advantage the spermatozoa within hostile female genital tract. In contrast, profound pro-inflammatory leukocytosis been observed post-coitus in animals and humans. Whether components of involved initiating this leukocytic reaction is not known. This study investigated effect human plasma, fraction its principal constituent prostaglandins, prostaglandin E2 (PGE2) 19-hydroxy PGE, on release...
• Premise of the study: Gravity has been a major force throughout evolution terrestrial organisms, and plants have developed exquisitely sensitive, regulated tropisms growth patterns that are based on gravity vector. The nullified during spaceflight allows direct assessment roles. microgravity environments provided by Space Shuttle International Station made it possible to seek novel insights into perception at organismal, tissue, cellular levels. Cell cultures Arabidopsis thaliana perceive...
Life in spaceflight demonstrates remarkable acclimation processes within the specialized habitats of vehicles subjected to myriad unique environmental issues associated with orbital trajectories. To examine response that occur plants space, leaves and roots from Arabidopsis (Arabidopsis thaliana) seedlings three GFP reporter lines were grown seed for 12 days on International Space Station preserved orbit RNAlater returned Earth analyzed by using iTRAQ broad-scale proteomics procedures. Using...
Lipoxin A 4 is a lipid mediator that elicits anti-inflammatory and pro-resolution actions via its receptor, formyl peptide receptor 2 (FPR2/ALX). In this study, we aimed to investigate the expression potential role of lipoxin FPR2/ALX in regulation inflammation associated with cyclical remodeling human endometrium across menstrual cycle during early pregnancy. Using quantitative RT-PCR analysis, found upregulated phase decidua tissue from first trimester We localized site first-trimester...