A5029611009- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Molecular Junctions and Nanostructures
- Advanced Machining and Optimization Techniques
- Crystallization and Solubility Studies
- Biosensors and Analytical Detection
- X-ray Diffraction in Crystallography
- Advanced Surface Polishing Techniques
- DNA and Nucleic Acid Chemistry
- Radical Photochemical Reactions
- Corrosion Behavior and Inhibition
- Metal and Thin Film Mechanics
- Advanced Biosensing Techniques and Applications
- Advanced Chemical Sensor Technologies
- Molten salt chemistry and electrochemical processes
- Nanopore and Nanochannel Transport Studies
- Advanced machining processes and optimization
- Organic Electronics and Photovoltaics
- Force Microscopy Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Porphyrin and Phthalocyanine Chemistry
- Crystallography and molecular interactions
University of Edinburgh
2016-2025
Robert Bosch (Germany)
2019
Observatoire de Paris
2018
Laboratoire d’études spatiales et d’instrumentation en astrophysique
2018
Austrian Academy of Sciences
2018
University of St Andrews
2010
National Microelectronics Institute
2008
Edinburgh College
2005
University of Oxford
1992
Imperial College London
1990-1991
Experimental results from electrochemical e.s.r. on electrodes modified with conducting polymers such as polyaniline, polypyrrole and polythiophene are presented. The show that the polymer exists in two forms, one stable when it is insulating (α) other (β) conducting. In region kinetics of transformation metastable α form into β can be followed by It further shown lightly oxidised films there a one-to-one correlation between charge injected spins. These explained chemical redox model opposed...
Peptide-based electrochemical biosensors typically consist of a short peptide sequence, labelled with redox reporter and modified thiol-containing moiety to allow immobilisation onto gold electrode surface. A spacer is often introduced between the thiol group aim promoting enzyme accessibility as well conferring flexibility probe. Herein we report systematic study effect polyethylene glycol (PEG)-based length on performance such in order gain deeper understanding their role optimise...
Electrochemical peptide-based biosensors are attracting significant attention for the detection and analysis of proteins. Here we report optimisation evaluation an electrochemical biosensor protease activity using self-assembled monolayers (SAMs) on gold surfaces, trypsin as a model protease. The principle was specific proteolytic cleavage redox-tagged peptides by trypsin, which causes release redox reporter, resulting in decrease peak current measured square wave voltammetry. A systematic...
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating selectively increasing the dose delivered to hypoxic regions. Here we describe miniature implantable sensor for real-time monitoring tissue oxygenation that enable this novel treatment approach implemented. The uses solid-state electrochemical cell was microfabricated at wafer level on silicon substrate, includes an integrated reference electrode electrolyte...
Surfactant molecules in solvents self-assemble into a large variety of structures depending on their chemical composition, concentration and temperature, summarized the system’s equilibrium phase diagram. However, occurrence of...
To describe charge conduction in conducting polymers a dual transmission line with one resistance describing electronic motion the polymer and second ionic pores has proved applicable to number of systems. A further feature ac impedance plots for these is high-frequency semicircle. This may be attributed charge-transfer double-layer capacitance at either electrode/polymer or polymer/electrolyte interface. general expression such derived it shown that current will proportional difference...
An MRSA assay requiring neither labeling nor amplification of target DNA has been developed. Sequence specific binding fragments bacterial genomic is detected at femtomolar concentrations using electrochemical impedance spectroscopy (EIS). This achieved systematic optimisation probe chemistry (PNA self-assembled monolayer film on gold electrode), electrode structure (the size and nature the chemical spacer) fragmentation, as these are found to play an important role in performance. These...
The manipulation of ribosomal RNA (rRNA) extracted from E. coli cells by dielectrophoresis (DEP) has been demonstrated over the range 3 kHz–50 MHz using interdigitated microelectrodes. Quantitative measurement total internal reflection fluorescence microscopy time dependent collection indicated a positive DEP response characterized plateau between kHz and 1 followed decrease in at higher frequencies. Negative was observed above 9 MHz. below is described Clausius–Mossotti model corresponds to...
A ruthenium-based mitochondrial-targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of PtIV prodrugs into their active PtII counterparts, and drives generation singlet oxygen was designed. This dual mode action two orthogonal cancer-cell killing mechanisms with temporal spatial control. The designed shown to elicit death a panel cancer lines including those showing oxaliplatin-resistance.
The electrochemical oxidation of a wide variety 5-substituted indole monomers at platinum electrode results in the formation redox active film. Electrochemical and spectroscopic evidence is consistent with species film being cyclic trimer. In contrast, electropolymerisation 5-aminoindole 5-hydroxyindole on does not result formation. This attributed to adsorption monomer onto metal via substituent, which inhibits this reaction. However, these predeposited 5-cyanoindole or 5-nitroindole...
Reaction of indole with Br2 led to isolation an trimer 2, formed by linking the 2- and 3-positions each form a central aromatic ring, brominated at 5- 6-positions indole. The X-ray structure [2]·acetone·2DMF showed π-stacking planar molecules two different overlap modes interplanar distances 3.287 Å 3.378 Å. Cyclic voltammetry one reversible oxidation for 2 phosphorescence from frozen ethanol solution was observed. adduct [2][TCNQ]2·4DMSO determined mixed stack arrangement where alternates...
Quantum dot (QD) labeling combined with fluorescence lifetime imaging microscopy is proposed as a powerful transduction technique for the detection of DNA hybridization events. Fluorescence analysis microarray spots hybridized QD labeled target indicated characteristic value 18.8 ns, compared to 13.3 ns obtained free solution, revealing that labels are sensitive spot microenvironment. Additionally, time gated was shown improve image contrast ratio by 1.8, achieving femtomolar sensitivity....
The synthesis and characterization of 1,4,5,8,9,12-hexamethyltriphenylene (5) is described. In the solid state, X-ray crystallographic studies reveal that compound 5 presents a highly distorted C2 geometry with 53 degrees end-to-end twist. solution, variable-temperature 1H NMR molecular modeling present story rapid dynamic conformational interconversions between two enantiomers (with low activation barrier) slower C2-D3 interconversion relatively high barrier)--the first time clear evidence...
Reaction of 2,4-bis(phenyl)-1,3-diselenadiphosphetane-2,4-diselenide [PhP(Se)(mu-Se)](2) (Woollins' reagent, WR) with one equivalent 1,4-diarylbutane-1,4-diones 1a-g in refluxing toluene affords the corresponding 2,5-diarylselenophenes 2a-g excellent yields (up to 99%). Alternatively, (2a and 2b) can be obtained 70-80% from reaction arylacetylene an O-methyl Se-hydrogen phenylphosphonodiselenoate; latter was derived WR methanol. The first X-ray structure is presented along characterisation...
Micron resolution photolithography has been employed to make microsquare nanoband edge electrode (MNEE) arrays with reproducible and systematic control of the crucial dimensional parameters, including array element size spacing nanoelectrode thickness. The response these arrays, which can be reproducibly fabricated on a commercial scale, is first established. resulting characteristics (including high signal signal-to-noise, low limit detection, insensitivity external convection fast,...