A5001765359- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Telemedicine and Telehealth Implementation
- Gastric Cancer Management and Outcomes
- Surgical site infection prevention
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Pressure Ulcer Prevention and Management
- Analytical Chemistry and Sensors
- Nanoplatforms for cancer theranostics
- COVID-19 and healthcare impacts
- Colorectal and Anal Carcinomas
- Anesthesia and Sedative Agents
- Hernia repair and management
- Enhanced Recovery After Surgery
- Artificial Intelligence in Healthcare and Education
- Gastrointestinal Bleeding Diagnosis and Treatment
- Clinical practice guidelines implementation
- Cancer Genomics and Diagnostics
- Abdominal Trauma and Injuries
- Genetic factors in colorectal cancer
- Ethics in Clinical Research
- Gastrointestinal motility and disorders
- Lung Cancer Diagnosis and Treatment
Western General Hospital
2008-2025
University of Birmingham
2023
Medical Research Council
2023
Edinburgh Cancer Research
2023
National University of Avellaneda
2023
ESCP Business School
2023
ESCP Business School
2023
NIHR Birmingham Biomedical Research Centre
2023
University of Edinburgh
1995-2022
Royal Stoke University Hospital
2014
Abstract Remote digital postoperative wound monitoring provides an opportunity to strengthen community care and minimise the burden of surgical-site infection (SSI). This study aimed pilot a remote service evaluate readiness for implementation in routine clinical practice. was single-arm implementational across two tertiary hospitals UK (IDEAL stage 2b, clinicaltrials.gov: NCT05069103). Adults undergoing abdominal surgery were recruited received smartphone-delivered assessment tool 30-days...
Surgical site infections (SSI) cause substantial morbidity and pose a burden to acute healthcare services after surgery. We aimed investigate whether smartphone-delivered wound assessment tool can expedite diagnosis treatment of SSI emergency abdominal This single-blinded randomised control trial (NCT02704897) enroled adult surgery patients in two tertiary care hospitals. Patients were (1:1) routine postoperative or additional access for 30-days postoperatively. Patient-reported symptoms...
Abstract Background Faecal immunochemical test (FIT)-directed pathways based on a single have been implemented for symptomatic patients. However, with test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) g faeces. This aims of this study were to define diagnostic performance FIT, compared double FIT in populations. Methods Two sequential prospective patient cohorts referred symptoms from primary care studied. Patients cohort 1 sent and those 2 received two tests succession before...
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating selectively increasing the dose delivered to hypoxic regions. Here we describe miniature implantable sensor for real-time monitoring tissue oxygenation that enable this novel treatment approach implemented. The uses solid-state electrochemical cell was microfabricated at wafer level on silicon substrate, includes an integrated reference electrode electrolyte...
Abstract Aim Ventral mesh rectopexy (VMR) is an established surgical treatment for rectal prolapse and outlet obstruction. In contrast to continental Europe, in the UK US use of synthetic has been abandoned favour biologic mesh, due concerns regarding related morbidity. The current study investigated if either material superior, terms clinical recurrence complications. Methods VMRs performed between March 2012 July 2022 three international pelvic floor centres were prospectively collected...
Abstract Remote monitoring is essential for healthcare digital transformation, however, this poses greater burdens on providers to review and respond as the data collected expands. This study developed a multimodal neural network automate assessments of patient-generated from remote postoperative wound monitoring. Two interventional studies including adult gastrointestinal surgery patients images patient-reported outcome measures (PROMs) 30-days postoperatively. Neural networks PROMs were...
AIM: To investigate the ability of Streptococcus bovis to colonise colorectal cancers. PATIENTS: 19 patients with cancer and 23 controls without malignancy. SETTING: University teaching hospital. METHODS: Prospective study comparing unselected known age sex matched controls. Carcinoma tissue from normal colonic mucosa, stool, blood both control subjects were cultured. RESULTS: In contrast published data, faecal carriage rate was similar in (11%) groups (13%). CONCLUSIONS: Faecal colonisation...
Abstract Objectives The aim of this study was, firstly, to evaluate the efficacy and acceptability rectal irrigation in treatment patients with disorders faecal continence that have not responded other modalities. Secondly, see if standard anorectal physiology measures can identify who might successful irrigation. Patients methods All had been treated irrigation, between 1998 2000, were sent a postal questionnaire. asked quantify their symptoms (before after irrigation) using visual analogue...
During a follow-up study of 19,790 pregnancies at risk for genetic disease, from 1968 to 1989, 1083 fetuses were found have an anomaly during the second trimester, leading 977 terminations pregnancy. Neural tube defects (31.4 per cent), chromosomal disorders (27.1 and Mendelian or multifactorial diseases (10.6 cent) main causes fetal anomaly. More than half (52.9 anomalies detected by routine ultrasound examination. Forty-two cent cystic hygromas secondary defect. We stress importance...
Abstract Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods internationally intended protocol, iteratively co-developed by multistage Delphi process, comprised online educational module introducing stratification, intraoperative checklist, harmonized surgical...
Abstract Introduction Remote monitoring can strengthen postoperative care in the community and minimise burden of complications. However, implementation requires a clear understanding how to sustainably integrate such complex interventions into existing pathways. This study aimed explore perceptions potential facilitators barriers digital remote from key stakeholders derive recommendations for an implementable service. Methods A qualitative was conducted wound across two UK tertiary...
Recent advances in the fields of electronics and microfabrication techniques have led to development implantable medical devices for use within field precision medicine. Monitoring visceral surface tissue O 2 tension ([Formula: see text]) by means an sensor is potentially useful many clinical situations, including perioperative management patients undergoing intestinal resection anastomosis. This concept could provide a which treatment be tailored individual patients. study describes vivo...
Abstract Objective Preoperative conditioning with oral fluid and carbohydrate (CHO) loading allows the patient to undergo surgery in fed state is associated reduced postoperative insulin resistance. Further benefit may accrue from nutritional supplements (ONS) counteract fasting mechanical bowel preparation (MBP). In this study we assess ability prescribe, dispense have patients comply a protocol combining preoperative ONS CHO/fluid during MBP. Method One hundred forty‐seven undergoing...
Rectus abdominis flap seems best
ABSTRACT Coccidioidomycosis is a common fungal infection acquired in the southwestern United States. This first study over 2 decades to determine seroincidence of Coccidioides immitis infections among U.S. military members performing training exercises an area endemicity. Only 8% participants were aware coccidioidomycosis, despite majority having visited or lived previously One (0.6%) 178 developed “definite” serologic evidence 5-week period; four (2.3%) additional patients “possible”...
We demonstrate a proof of concept highly miniaturised fluorescence imager and its application to detecting cancer in resected human colon tissues. Fluorescence imaging modalities have already been successfully implemented traditional endoscopy. However, the procedure still causes discomfort requires sedation. Wireless capsule endoscopy has potential improve diagnostic accuracy with less inconvenience for patients. In this paper we present 5 mm × 6 optical block that is small enough integrate...
Introduction National data suggest that surgical site infection (SSI) complicates 2%–10% of general surgery cases, although the patient-reported incidence is much higher. SSIs cause significant patient morbidity and represent a burden on acute healthcare services, in cohort predominantly suitable for outpatient management. Over three-quarters UK adults now own smartphones, which could be harnessed to improve access care. We aim investigate if smartphone-delivered wound assessment tool...
Anastomotic leakage (AL) is a common and dangerous post-operative complication following intestinal resection, causing substantial morbidity mortality. Ischaemia in the tissue surrounding anastomosis major risk-factor for AL development. Continuous oxygenation monitoring during recovery period would provide early accurate identification of risk. We describe construction testing miniature implantable electrochemical oxygen sensor that addresses this need. It consisted an array platinum...