A5085009013- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gallbladder and Bile Duct Disorders
- Total Knee Arthroplasty Outcomes
- Gastric Cancer Management and Outcomes
- Anesthesia and Pain Management
- Mycobacterium research and diagnosis
- Nausea and vomiting management
- Knee injuries and reconstruction techniques
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Palliative Care and End-of-Life Issues
- Appendicitis Diagnosis and Management
- Ultrasound and Hyperthermia Applications
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Microscopic Colitis
- Abdominal Trauma and Injuries
- Diverticular Disease and Complications
- Frailty in Older Adults
- Stoma care and complications
- Effects of Radiation Exposure
Edinburgh Cancer Research
2023-2025
Western General Hospital
2023-2025
Institute of Genetics and Cancer
2022
University of Edinburgh
2022
Southport and Ormskirk Hospital NHS Trust
2021
University of Liverpool
2015-2020
Blackpool Victoria Hospital
2015-2020
Aintree University Hospitals NHS Foundation Trust
2019
Lancashire Teaching Hospitals NHS Foundation Trust
2017-2018
Royal Preston Hospital
2017
Abstract Background Faecal immunochemical test (FIT)-directed pathways based on a single have been implemented for symptomatic patients. However, with test, the sensitivity is 87 per cent at 10 µg haemoglobin (Hb) g faeces. This aims of this study were to define diagnostic performance FIT, compared double FIT in populations. Methods Two sequential prospective patient cohorts referred symptoms from primary care studied. Patients cohort 1 sent and those 2 received two tests succession before...
Abstract Aim Microscopically positive resection margins (R1) are associated with poorer outcomes in colon cancer. While the sequalae of a margin related to primary tumour (R1Tumour) relatively well known, comparatively less is known when pertains metastatic lymph node (R1LNM). The aim this study confirm significance and impact R1LNM cancer patients. Method A retrospective, observational patients treated for American Joint Committee on Cancer Stage 3 potentially curative surgical intervention...
Lymph nodes (LNs) are believed to be the first organs targeted by colorectal cancer cells detached from a primary solid tumor because of their role in draining interstitial fluids. Better detection and assessment these have potential help clinicians stratification designing optimal design oncological treatments for each patient. Whilst highly valuable tumors, CT MRI remain limited characterization LNs. B-mode ultrasound (US) contrast-enhanced (CEUS) can improve LNs could provide critical...
Lynch syndrome (LS) carries a substantial lifetime risk of colorectal cancer which is currently mitigated by biennial colonoscopy surveillance. Paramount to the surveillance programme removal adenomas before malignant transformation but there an associated service burden and morbidity repeated endoscopy. We investigated if faecal immunochemical testing (FIT) for haemoglobin has diagnostic performance replace colonoscopy.
Non-steroidal anti-inflammatory drugs (NSAIDs) can produce diaphragm disease where multiple strictures develop in the small bowel. This typically presents with anaemia and symptoms of bowel obstruction. The as a result circumferential mucosal ulceration subsequent contraction rings scar tissue. We report case 47-year-old woman 6-month history NSAIDs abuse who presented subacute obstruction 1 year after stopping NSAIDs. CT MRI showed ileal florid locoregional lymphadenopathy. A malignant...
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CASE REPORT We present a 72-year-old man who was admitted to the gastroenterology ward after frank hematemesis. He had been seen 5 days prior in clinic with dysphagia, anorexia, weight loss, and pain epigastrium thoracic spine. At admission he stable normotensive blood pressure, not tachycardic, hemoglobin 12.5 g/dL. On examination there epigastric tenderness, but abdomen soft normal bowel sounds were no significant findings on rectal examination. After intravenous fluid resuscitation, his...
CASE REPORT An 80-year-old woman presented with acute cholecystitis. On admission she was pyrexic and tachycardic raised serum inflammatory markers. Computed tomography (CT) confirmed the diagnosis. She had significant morbidity from multiple sclerosis. left paresis wheelchair-bound. In view of her poor baseline function, infection managed a percutaneous cholecystostomy drain. recovered well intravenous antibiotics drainage infected gallbladder. After removal cholecystostomy, drain track...
This study aimed to describe the faecal immunochemical test non-return rate of those referred with high-risk symptoms colorectal cancer from primary care, and clinical outcomes 'non-returners'.
We present the case of a 22-year-old man transferred to regional major trauma centre following fall ~15 m. He remained consistently haemodynamically stable for over 10 hours observation until he deteriorated suddenly with haemorrhagic shock requiring immediate laparotomy. At laparotomy, 2 L blood was drained from abdomen but no source active bleeding identified. 30 minutes after closure abdomen, 500 mL fresh noted in drain so returned theatre where found be-after manual compression mildly...
Background: Postoperative pain after major knee surgery can be severe. Our aim was to compare the outcomes of epidural analgesia and peripheral nerve blockade (PNB) in patients undergoing total joint replacement (TKR). Moreover, we aimed adductor canal block (ACB) with those femoral (FNB) TKR. Methods: We conducted a systematic search electronic information sources, including MEDLINE; EMBASE; CINAHL; Cochrane Central Register Controlled Trials (CENTRAL). applied combination free text...
Primary bile duct perforation is rare in adults.It commonly results biliary peritonitis and high morbidity mortality.We present a 72-year-old man who was initially admitted with biochemically diagnosed pancreatitis found to have collection limited the lesser sac.This presented diagnostic challenge and, due its containment, did not result generalized peritonitis, which usually associated this condition.His condition managed stenting endoscopic retrograde cholangiopancreatography.
The aim of this study was to determine if the type reamer used in tibial tunnel creation during anterior cruciate ligament (ACL) reconstruction influences dimensions tunnel's outer aperture. Tibial tunnels were created saw bones by reaming over a guidewire using an 8 mm acorn or fluted antegrade manner. Reaming aimed either line with guidewire, 10-degree inferior/superior deviation relation wire. shape and size aperture compared between two reamers. When reamer, resulted minimal change...
Abstract The commissioning guide for colonic diverticular disease by the Royal Collage of Surgeons (2014) states that all patients should undergo luminal investigations once an acute attack diverticulitis has passed. rational behind this is to ensure a malignant polyp not missed, however there mounting evidence and opinion may be necessary. We aim evaluate how our unit follows investigate number subsequent polyps cases malignancy found. Surgical inpatients with CT proven diagnosis within one...
Abstract Aim Surgery in the elderly carries greater risk of mortality with those who are frail being most at risk. We aimed to review our outcomes for patients 70 years age and over, underwent emergency laparotomy. Methods All aged over had undergone laparotomy within a 12-month period were included analysis. Patient’s pre-operative was assessed by P-Possum NELA scoring along Rockwood Frailty Scale (RFS) Geriatric rescue after surgery (GRAS) score. Results 50/116 undergoing old. Full data...