A5008998397- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Cardiovascular Health and Disease Prevention
- Electrical and Bioimpedance Tomography
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Characterization and Applications of Magnetic Nanoparticles
- Palliative Care and End-of-Life Issues
- Ultrasonics and Acoustic Wave Propagation
- Coral and Marine Ecosystems Studies
- Colorectal Cancer Surgical Treatments
- Childhood Cancer Survivors' Quality of Life
- Coronary Interventions and Diagnostics
- Coastal and Marine Management
- Cancer Cells and Metastasis
- Cardiovascular Function and Risk Factors
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Wireless Power Transfer Systems
- Marine and fisheries research
- Family Support in Illness
Lund University
2016-2023
Ghent University
2023
University of the Highlands and Islands
2023
Environmental Research Institute
2023
University of Strathclyde
2022
Edinburgh Cancer Research
2022
Abstract With the rapid expansion of offshore windfarms (OWFs) globally, there is an urgent need to assess and predict effects on marine species, habitats, ecosystem functioning. Doing so at shelf-wide scale while simultaneously accounting for concurrent influence climate change will require dynamic, multitrophic, multiscalar, ecosystem-centric approaches. However, as such studies study system itself (shelf seas) are complex, we propose structure future environmental research according...
Lymph nodes (LNs) are believed to be the first organs targeted by colorectal cancer cells detached from a primary solid tumor because of their role in draining interstitial fluids. Better detection and assessment these have potential help clinicians stratification designing optimal design oncological treatments for each patient. Whilst highly valuable tumors, CT MRI remain limited characterization LNs. B-mode ultrasound (US) contrast-enhanced (CEUS) can improve LNs could provide critical...
The longitudinal movement of the arterial wall large human arteries has shown promise to be an independent indicator vascular health. Despite growing interest in this movement, its nature, causes, and implications are not fully understood, existing phantoms have failed show a pure that is secondary distension. An often overlooked aspect interaction between different layers. innermost layers, intima media, can several hundred micrometers direction flow during early systole. This markedly...
Abstract Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise an indicator vascular health. The underlying mechanisms are however not fully understood. We have found, in vivo studies, that blood pressure a strong relation to antegrade longitudinal displacement early systole. Further, we identified tapered geometry and intramural friction in‐between two parts vessel wall influence displacement. therefore studied interaction between pressure,...
A key challenge in the treatment of colorectal cancer is identification sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified nodes rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated are forced to oscillate by an external magnetic field; resulting axial displacement recovered allowing structure delineation with potential indicate alterations tissue stiffness, but it limited small vibration amplitudes. We propose CE-MMUS using SPION loaded...
In magnetomotive ultrasound (MMUS), solenoids have been extensively used to generate varying magnetic fields, that act move nanoparticles and their surrounding tissue. Here we show, compare contrast two devices, one based on a solenoid, another containing rotating permanent magnet. Suitable field characteristics for this application include high flux density gradient, uniform laterally in the image plane, corresponding design features are highlighted. Field measurements show both magnets...
The development of new ultrasound imaging technologies that aim to resolve objects smaller than the conventional ultrasounds diffraction limit calls for types phantoms evaluate these technologies. When it comes vascular flow phantoms, this becomes challenging due difficulty manufacturing with vessels 1 mm in diameter. Here we describe a novel method construct micro-vessels size down 88 μm using oil-based clear ballistic gel (Clear Ballistics, Greenville, SC, USA) as surrounding material....
Magnetomotive ultrasound, MMUS, can reveal the presence of a magnetic contrast agent by applying an external field. If interaction between and field is strong enough, movement that be detected ultrasound induced in surrounding tissue, thereby inferring distribution. Electromagnets have been used to generate necessary field, but due their size, weight, propensity heat up, they are impractical work with. Furthermore, resulting force directed mainly along symmetry axis such magnets, thus...
Magnetomotive ultrasound is an emerging technique that enables detection of magnetic nanoparticles. This has implications for molecular imaging, and potentially addresses clinical needs regarding determination metastatic infiltration the lymphatic system. Contrast achieved by a time-varying field sets nanoparticle-laden regions in motion. motion governed vector-valued mechanical forces. Understanding how these forces contribute to observed displacement patterns important interpretation...
Objectives: Despite advances in MRI the detection and characterisation of lymph nodes rectal cancer remains complex, especially when assessing response to neoadjuvant treatment. An alternative approach is functional imaging, previously shown aid tissues. We report proof concept novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) recover information relating local perfusion lymphatic drainage, interrogate tissue mechanical properties through magnetically induced...
In magnetomotive ultrasound (MMUS), magnetic nanoparticles (MNPs) are used as a contrast agent. A time-varying field displaces the MNPs which in turn move their closest surrounding - motion detected with ultrasound. limiting factor for MMUS is force magnitude decay depth, restricts imaging area. Several attempts to extend depth have been suggested, such generator configuration or choice of MNP core materials. this study we present new approach by modifying design agent using commercially...
Early and accurate diagnoses are important for successful cancer treatment. Lymph node involvement is often critical, magnetomotive ultrasound (MMUS) has been proposed its detection characterization. MMUS relies on a magnetic contrast agent, example, iron oxide nanoparticles, delivered to the tissue of interest, magnetically set in motion detected using ultrasound. The magneto–mechanical interaction not previously evaluated cellular level. Here we demonstrate uptake dose-dependent retention...
Despite advances in MRI, the detection and characterisation of lymph nodes rectal cancer remains complex, especially when assessing response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown aid characterization tissues. We report proof-of-concept novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) recover information relating local perfusion lymphatic drainage, interrogate tissue mechanical properties through magnetically induced...
A new approach for the detection and characterisation of lymph nodes (LN) colorectal cancer staging has been implemented in this study. Contrast Enhanced Magnetomotive Ultrasound (CE-MMUS) is aiming to combine CEUS MMUS using Magnetic NanoParticles(MNP)-microbubbles improved differentiation tissues LNs. Biotinylated MNPs were administered left hock a mouse 24 hours prior imaging targeted microbubbles intravenously immediately before imaging. CE-MMUS performed Vevo 3100 preclinical ultrasound...