A5033946976- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- BRCA gene mutations in cancer
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Ultrasound in Clinical Applications
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Cellular Mechanics and Interactions
- Soft tissue tumor case studies
- Celiac Disease Research and Management
- RNA modifications and cancer
- Vitamin D Research Studies
Lancashire Teaching Hospitals NHS Foundation Trust
2024
Royal Preston Hospital
2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Liverpool
2015-2021
University of Birmingham
2020-2021
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
BackgroundThe aim was to describe genetic, clinical and morphological features in a large, multicentre European cohort of patients with SPINK1 related pancreatitis, comparison idiopathic pancreatitis (IP).MethodsAll mutation carriers pancreatic symptoms from two French one English centers were included. Patients IP included control group. Genetic, clinical, radiological biochemical data collected.Findings209 302 the groups (median follow-up: 8.3 years (3.7–17.4) vs 5.3 (2.5–8.8)).The median...
Intraductal papillary mucinous neoplasms (IPMNs) are associated with risk of pancreatic ductal adenocarcinoma (PDAC). It is unclear if an IPMN in individuals at high PDAC should be considered as a positive screening result or incidental finding. Stratified familial cancer (FPC) populations were used to determine linked PDAC.
Abstract Background Many differences exist in postgraduate surgical training programmes worldwide. The aim of this study was to provide an overview the requirements general surgery across 23 different countries. Methods A collaborator affiliated with each country collected data from country's official body website, where possible. information included: management, teaching, academic and operative competencies, mandatory courses, years (inclusive intern years), working-hours regulations,...
Non-steroidal anti-inflammatory drugs (NSAIDs) can produce diaphragm disease where multiple strictures develop in the small bowel. This typically presents with anaemia and symptoms of bowel obstruction. The as a result circumferential mucosal ulceration subsequent contraction rings scar tissue. We report case 47-year-old woman 6-month history NSAIDs abuse who presented subacute obstruction 1 year after stopping NSAIDs. CT MRI showed ileal florid locoregional lymphadenopathy. A malignant...
Abstract Background The oesophagogastric (OG) tertiary referral centre at our Trust was established in March 2009.It caters to a catchment population of approximately 1.6 million. Oesophageal cancer is morbid disease contributing 18% mortalities worldwide. Involvement circumferential resection margin (CRM) an indicator poor prognosis. aim calculate the microscopic positive rate patients undergoing resections for oesophageal cancers, assess free survival (DFS) and overall (OS) this cohort....
Abstract Background Oesophageal perforation in elderly and frail patients carries a significantly higher mortality rate. Traditionally, management involves surgery for who are fit surgery, or conservative approach those with minimal contamination. Endoscopy, procedures such as endoscopic washout of mediastinal collections placement covered removable stents, sometimes conjunction chest drain insertion, is emerging minimally invasive option selected group not suitable traditional methods. This...
Abstract Background Oesophageal cancer, including squamous cell carcinoma (SCC) and adenocarcinoma, is challenging due to its aggressive nature delayed presentation. Neoadjuvant chemotherapy aims downstage the tumour thus aids in surgery improves patient outcomes. Complete resection with free margins crucial for cure survival. Understanding relationship between regression grade (TRG) completeness of helps improve outcomes patients oesophageal cancer. Method This retrospective study was...
Abstract Background Oesophageal perforation is a life-threatening emergency that requires prompt and effective management. This study aims to evaluate the outcomes of different management strategies—conservative, surgical, endoscopic washout with stent insertion—for non-malignant oesophageal perforations at specialist Upper GI unit in tertiary care hospital. Method retrospective conducted over 10-year period from 2012 Unit All patients aged 18 above who were referred or admitted included,...
We describe two cases of recurrent major umbilical bleeding in male patients with Childs A liver cirrhosis and portal hypertension.Both had hernias omentum incarcerated the hernial sac.In both cases, portosystemic abdominopelvic CT scan shown omental varices without significant paraumbilical cutaneous varices.Previous reports have that venous communication can develop between overlying abdominal wall scars, resulting spontaneous bleeding.We concluded there was a similar mechanism for our...
The finding of unusual contents within hernias merits publication so as to raise surgeons’ awareness the structures that could be encountered during hernia repair.1 ,2 We describe a case 66-year-old man who underwent elective transabdominal preperitoneal bilateral inguinal repair. At laparoscopy, large cystic structure was seen arising from pelvis (figure 1). were repaired and patient informed abdominal before being discharged home later …