A5037591262- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Poisoning and overdose treatments
- Systemic Lupus Erythematosus Research
- Forensic Toxicology and Drug Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nanoparticles: synthesis and applications
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Hepatotoxicity and Protection
- T-cell and B-cell Immunology
- Nutrition and Health Studies
- Air Quality and Health Impacts
- Eosinophilic Disorders and Syndromes
- Alcoholism and Thiamine Deficiency
- Angiogenesis and VEGF in Cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- Heavy Metal Exposure and Toxicity
- Heme Oxygenase-1 and Carbon Monoxide
- Public health and occupational medicine
- Hormonal and reproductive studies
- Silymarin and Mushroom Poisoning
Gdańsk Medical University
2015-2024
The Ohio State University
2008-2023
Centralny Szpital Kliniczny
2015
NZOZ Centrum Alergologii
2013
The Ohio State University Wexner Medical Center
2007-2010
Interface (United States)
2010
Baylor College of Medicine
2004
University of Minnesota
2004
University of Minnesota Medical Center
2004
Texas Biomedical Research Institute
2004
Abstract The impact of the immune response in malignancy is poorly understood. While cells can destroy transformed cells, targeting and accumulation monocytes macrophages at tumor sites may promote metastases. growth factor M-CSF important promoting monocyte survival. Since M-CSF−/− mice are protected against metastases, we hypothesized that induced to produce angiogenic factors facilitate In this study demonstrate recombinant human induces freshly isolated normal release vascular...
Background. Despite progress in antiviral chemotherapy, cytomegalovirus (CMV) remains a major cause of morbidity and mortality among pharmacologically immunosuppressed organ transplant recipients, frequently engaging the clinician struggle to balance graft preservation with control CMV disease. Leflunomide, an inhibitor protein kinase activity pyrimidine synthesis, is experimental immunosuppressive agent effective against acute chronic allograft rejection animal models. Because number...
Despite progress in antiviral chemotherapy, cytomegalovirus (CMV) remains a major cause of morbidity and mortality among pharmacologically immunosuppressed transplant recipients, frequently engaging the clinician struggle to balance graft preservation with control CMV disease. Leflunomide, an inhibitor protein kinase activity pyrimidine synthesis, is experimental immunosuppressive agent effective against acute chronic rejection animal models. Herein we summarize our recent studies...
Abstract The type I IFNs represent a primordial, tightly regulated defense system against acute viral infection. IFN-α confers resistance to infection by activating conserved signal transduction pathway that up-regulates direct antiviral effectors and induces immunomodulatory activities. Given the critical role of in anti-human cytomegalovirus (HCMV) immunity profound ability HCMV escape host immune response, we hypothesized blocks IFN-α-stimulated responses disrupting multiple levels...
Cytomegalovirus (CMV) infects multiple tissues and organs; however, mechanisms of dissemination remain elusive. Although hematogenous spread has been implicated, in vitro studies have generally indicated that peripheral blood mononuclear cells (PBMC) do not support the complete viral reproductive cycle. Since CMV endothelial (EC), hypothesis PBMC can be productively infected by contact with CMV-infected EC was tested coculturing monolayers. Dual immunohistochemical staining for cell markers...
Cytomegalovirus (CMV) viremia that is resistant or refractory to the standard antiviral therapy still constitutes a major threat high-risk transplant recipients. In addition, multiple CMV recurrences may lead neutropenia because of repeated courses with ganciclovir derivatives. Leflunomide, drug for rheumatoid arthritis, has been reported have anti-CMV activity. This study reports on its use in 17 recipients complex syndromes who had failed were intolerant other therapies.Single-center,...
Toxicity of commercial nanoparticles titania, silica, and zinc oxides is being investigated in this vitro study. Particles these compositions are found many food items, thus study directed toward particle behavior simulated digestion media their interaction with intestinal epithelial cell line C2BBe1, a clone Caco-2 cells, originally isolated from human colon cancer. Even though the primary size all three particles was below 50 nm, appeared as aggregates culture negatively charged surface....
Review of the properties food-relevant nanoparticles including gastrointestinal tract exposure, transport, and immunogenicity.
Introduction Cannabis is the most common recreational drug worldwide and synthetic cannabinoid receptor agonists are currently largest group of new psychoactive substances. The aim this study was to compare clinical features outcomes lone acute cannabis toxicity with agonist in a large series presentations European emergency departments between 2013-2020.
Endothelial involvement has been implicated in cytomegalovirus (CMV) infection, a source of major complications immunosuppressed individuals (e.g., those with acquired immune deficiency syndrome [AIDS] and organ transplants). Traditionally, CMV grown fibroblasts; however, propagation these cells may alter characteristics the virus. In developing an vitro model system CMV/endothelial cell interaction, we have addressed this issue by propagating clinical isolate, VHL 1, human umbilical vein...
We previously reported that the immunosuppressive malononitrileamides leflunomide and FK778 exert antiviral activity against cytomegalovirus (CMV). In current investigation, we tested hypothesis exerts concurrent immune suppression in CMV-infected cardiac allograft recipients. Lewis rats were transplanted with Brown Norway hearts then inoculated rat CMV. Plaque assay demonstrated (30 mg/kg/day) reduced viral loads by 4-6 logs, reduction load was unaffected administration of uridine....
Background. Despite advances in antiviral chemotherapy, herpes simplex virus type 1 (HSV-1), continues to complicate the clinical course of many allograft recipients. We have previously demonstrated that experimental immunosuppressive agent leflunomide inhibits production cytomegalovirus by interference with virion assembly. test hypothesis this exerts similar activity against HSV-1 Methods and Results. Plaque assay yield from endothelial or Vero cells after inoculation each four isolates a...
Interstitial lung disease compatible with idiopathic pulmonary fibrosis (IPF) developed in 19 previously healthy patients. Although interstitial and/or honeycomb parenchymal was present all, there were patchy areas of paucicellular septal capillary injury along corroborative direct immunofluorescent evidence a humorally mediated microvascular syndrome. Significantly elevated factor VIII levels seen 17 18 patients tested. Antiphospholipids all tested, comprising antibodies...
Cellular immunity is the reputed mechanism of lung allograft failure. Humoral not a commonly recognized pathway.We describe 22 patients who developed posttransplantation septal capillary injury syndrome in absence panel-reactive antibodies. Factor VIII levels served as an index microvascular injury. Routine light microscopic studies were performed total 73 biopsies; 54 biopsy specimens analyzed for deposition C1q, C4d, C5b-9, and immunoglobulin (IgG, IgM, IgA). Indirect immunofluorescent...
Cytomegalovirus, a source of serious complications among immunosuppressed individuals, infects endothelial cells in vivo, and has been epidemiologically associated with allograft rejection transplantation-associated accelerated arteriosclerosis (TxAA). As the interface between host immune system tissues, endothelium may be primary importance mediating pathogenic responses to CMV. We have therefore investigated T lymphocyte CMV-infected allogeneic human umbilical vein (HUVE) vitro....
Sphingolipids are present in membranes of all eukaryotic cells. Bioactive sphingolipids also function as signaling molecules that regulate cellular processes such proliferation, migration, and apoptosis. Human cytomegalovirus (HCMV) exploits a variety pathways to promote its own replication. However, whether HCMV modulates lipid is an essentially unexplored area research virus-host cell interactions. In this study, we examined the accumulation bioactive enzymes responsible for biosynthesis...
This study focuses on an aqueous one-pot method for synthesis of CdSe/ZnS core/shell QDs using microwave radiation. The novelty the is use Zn(NH3)42+ as zinc source. Using initial solution with composition Cd1Se1Zn6MPA20, obtained upon heating at 160 °C 60 min were not high quality, evidenced by a quantum yield 1.5%, due to poor interface between core and shell. Postsynthesis UV irradiation as-prepared 30 could be used improve 22%, but technique practical large-scale applications. By...