A5027896165- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Organ Donation and Transplantation
- Liver Diseases and Immunity
- Genetic and Kidney Cyst Diseases
- Congenital Anomalies and Fetal Surgery
- Hematopoietic Stem Cell Transplantation
- Renal and Vascular Pathologies
- Immune Cell Function and Interaction
- Metabolism and Genetic Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Congenital gastrointestinal and neural anomalies
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- Congenital heart defects research
- Neuroblastoma Research and Treatments
- Organ and Tissue Transplantation Research
- Hemodynamic Monitoring and Therapy
- Tumors and Oncological Cases
- Bone Tumor Diagnosis and Treatments
Children's Memorial Health Institute
2010-2024
HCC constitutes 25-30% of primary malignant liver tumors in children. Conventional surgical excision is not possible more than 50% patients. LTx has recently become an important therapeutic option for adults and children with tumors. The aim this study was a retrospective analysis the clinical pathological data treated relation to Milan criteria assessed at diagnosis then immediately before transplantation, comparison group patients conventionally. Between 1990 2007 we have 21 diagnosed HCC....
The histological prevalence of allograft fibrosis in asymptomatic children after liver transplantation (LT) is well documented. However, long-term graft and patient survival remain unclear. This retrospective multicenter study aims to determine the analyze outcome for patients transplanted childhood.We reviewed clinical data who had undergone 10-y protocol biopsies. We excluded with autoimmune hepatitis, primary sclerosing cholangitis, hepatitis B or C, retransplantation. In total, 494...
BACKGROUND:The aim of our study was to retrospectively assess any correlation between graft fibrosis and selected immunological factors in pediatric liver transplant recipients. MATERIAL AND METHODS:The performed on 33 patients after living related donor transplantation, divided into 2 groups depending history acute rejection episodes transplantation. We assessed biopsies for presence fibrosis, signs antibody-mediated rejection, inflammatory infiltrations, changes bile ducts. correlated...
Various congenital and acquired diseases of the lower urinary tract can lead to chronic renal failure requiring replacement therapy.The aim study was assess problems results kidney transplantation in children with significant dysfunction.Between 1984 2007, there were 33 transplantations end-stage disease severe dysfunction out 539 performed our department. The patients 23 males 10 females. Thirty received a from deceased donor, remaining 3 living related donor. age at ranged 2.25 years 19...
Background and rationale for the study. The aim of study was to determine prognostic value histopathological findings with special care severity liver fibrosis at moment hepatoportoenterostomy (HPE) in children biliary atresia (BA). We performed analysis 142 wedge biopsies taken time HPE. All patients were operated by same surgical team between 1995 2007. According outcome 6 months after HPE divided into groups: group 1-bilirubin level < 2 mg% (n = 65), 2-bilirubin > 77). Liver re-evaluated...
Objectives Living donor liver transplantation (LDLT) in patients with acute failure (ALF) has become an acceptable alternative to from deceased donors (DDLT). The aim of this study was analyze outcomes LDLT pediatric ALF based on our center’s experience. Material and methods We enrolled 63 children (at institution) who underwent between 1997 2016. Among them 24 (38%) a 39 (62%) received DDLT. Retrospectively analyzed patient clinical data included: time lapse qualification for transplant...
Aspergillus infection in immunocompromised patients is associated with high morbidity and mortality. We retrospectively reviewed cases of Aspergillosis (A), a series 277 children who received LTx between 1990 2006. All were given antifungal prophylaxis after transplantation. was identified 10 (3.6%) diagnosis confirmed when clinical symptoms identification sp. or detection galactomannan antigen. Incidence considerably decreased from 6.9% to 0.6% liposomal amphotericin B introduced as...
Abstract: The aim of this study was to present acute hemodynamic failure as a rare indication for liver transplantation in neonates and infants with hemangiomatosis. We report four patients aged one six months giant hemangiomas, huge arterio‐venous shunting within these malformations. In three, many skin hemangiomas were found. All children developed right ventricular failure. two, trial pharmacological reduction attempted corticosteroids cyclophosphamide. patient, the fistulas embolized...
BACKGROUND Biliary strictures (BS) are frequent after pediatric liver transplantation (LTx) and in spite of ongoing progress, they remain a significant cause morbidity. In children, the majority reconstruction is hepatico-jejunal anastomosis (HJA). The aim this study was to analyze our experience percutaneous transhepatic treatment BS. MATERIAL AND METHODS Between 1998 2014, 589 (269 living donor) LTx were performed institution. We retrospectively reviewed clinical data patients with HJA who...
The current gold standard to diagnose T-cell-mediated acute rejection (TCMR) requires liver histology. Using data from the ChilSFree study on immune response after paediatric transplantation (pLT), we aimed assess whether soluble cytokines can serve as an alternative diagnostic tool in children suspected have TCMR.A total of n = 53 blood samples obtained day or up 3 days before biopsy performed for TCMR at median 18 (range 7-427) pLT 50 (38% female, age 1.8 (0.5-17.5) years) were analysed...
BACKGROUND:The diagnosis of post-liver transplant biliary strictures (BS) requires a high degree clinical suspicion because the diversity symptoms and usually mild presentation. If quickly treated, successful outcome is achieved most cases. The aim our study was to analyze value diagnostic methods in BS after pediatric LTx. MATERIAL AND METHODS:We retrospectively reviewed data children with liver transplantation, main focus on methods, including imaging studies histology. All patients...
An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim our study was establish value ABOi LT from available retrospective results AB0i pediatric performed European reference centers now belonging TransplantChild, Reference Network (ERN). Data medical records were analyzed, including demographic data, diagnosis, urgency transplantation, time on...
The aim of the study was to assess efficacy and safety endoscopic treatment in BS after pediatric LTx.We retrospectively reviewed data patients with DDA who developed underwent ERCP.Of 189 transplanted DDA, strictures 30 (16%). In this subgroup, median age at LTx 14.7 (1.5-17.6) follow-up period 3.9 (1.3-11.3). ABS were 76% NABS combination 24% patients. Overall, 95 ERCP sessions (3.0 per patient) performed successful outcome 22 (73%) cases. Duration 9.1 (1.8-24.1) months. Five surgical...
Histopathological diagnosis of chronic constipation in children is difficult and time-consuming because the aetiology problem heterogenous.To create optimal immunohistochemical (IHC) histological diagnostic protocol using novel antibodies assessing precisely their patterns.Twenty-eight paediatric patients were enrolled to study. The study group consisted following: 9 with confirmed Hirschsprung's disease (HD), 11 desmosis colon (DC) (3) or unknown (3), eight operated on due other problems....
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