A5079841184- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Reproductive tract infections research
- Microtubule and mitosis dynamics
- Reproductive Biology and Fertility
- Action Observation and Synchronization
- Cancer Immunotherapy and Biomarkers
- Embodied and Extended Cognition
- Innovative Human-Technology Interaction
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Vitamin D Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Urinary Tract Infections Management
- Virtual Reality Applications and Impacts
- Mesenchymal stem cell research
- Sport Psychology and Performance
- Urinary Bladder and Prostate Research
- Cancer, Hypoxia, and Metabolism
- Hematological disorders and diagnostics
- Infant Development and Preterm Care
- Genetic Mapping and Diversity in Plants and Animals
Kennesaw State University
2023-2024
University of Florida Health Science Center
2015-2016
University of Florida
2007-2016
Chlamydiae are Gram negative, obligate intracellular bacteria, and Chlamydia trachomatis is the etiologic agent of most commonly reported sexually transmitted disease in United States. undergo a biphasic life cycle that takes place inside parasitophorous vacuole termed an inclusion. Chlamydial infections have been epidemiologically linked to cervical cancer patients previously infected by human papillomavirus (HPV). The inclusion associates very closely with host cell centrosomes, this...
The tumor microenvironment impacts pancreatic cancer (PC) development, progression and metastasis. How intratumoral inflammatory mediators modulate this biology remains poorly understood. We hypothesized that the milieu within PC would correlate with clinicopathologic findings survival. Pancreatic specimens from normal pancreas (n = 6), chronic pancreatitis 9) adenocarcinoma 36) were homogenized immediately upon resection. Homogenates subjected to multiplex analysis of 41 mediators....
Current bone marrow dosimetry methods inherently assume that the target cells of interest for assessment leukemia risk (stochastic effects) or toxicity (deterministic are uniformly localized throughout cavities cancellous bone. Previous studies on mouse femur, however, have demonstrated a spatial gradient hematopoietic stem and progenitor cells, with higher concentrations near surfaces. The objective present study was to directly measure concentration these as well vasculature structures,...
Chlamydia trachomatis is an obligate intracellular bacteria and the infectious agent responsible for sexually transmitted disease Chlamydia. Infection with can lead to serious health sequelae such as pelvic inflammatory reproductive tract scarring contributing infertility ectopic pregnancies. Additionally, chlamydial infections have been epidemiologically linked cervical cancer in patients a prior human papilomavirus (HPV) infection. Chlamydial infection of cultured cells causes...
The relationship between smoking and pancreatic cancer biology, particularly in the context of heterogeneous microenvironment, remains incompletely defined. We hypothesized that nicotine exposure would lead to augmentation paracrine growth factor signaling tumor-associated stroma (TAS) cells, ultimately resulting accelerated tumor metastasis.The effect tobacco use on overall survival was analyzed using a prospectively maintained database surgically resected patients with cancer. Nicotine...
Chlamydia are Gram negative, obligate intracellular bacterial organisms with different species causing a multitude of infections in both humans and animals. trachomatis is the causative agent sexually transmitted infection (STI) Chlamydia, most commonly acquired STI United States. Chlamydial have also been epidemiologically linked to cervical cancer women co-infected human papillomavirus (HPV). We previously shown chlamydial results centrosome amplification multipolar spindle formation...
The developmental cycle of the obligate intracellular pathogen Chlamydia is dependant on formation a unique niche termed chlamydial inclusion. inclusion membrane bound vacuole derived from host cytoplasmic and modified significantly by insertion proteins. A property its propensity for homotypic fusion. vast majority cells infected with multiple elementary bodies (EBs) contain only single mature protein IncA required fusion, however process involved are uncharacterized.Here, through live...
Chlamydia trachomatis is an obligate intracellular bacterial pathogen and the second leading cause of sexually transmitted infections in US. Infections significant morbidity can lead to serious reproductive sequelae, including epidemiological link increased rates cancers. One overt changes that infected cells exhibit development genomic instability multinucleation. Here we demonstrate induction multinucleation not conserved equally across chlamydial species; C. L2 caused high levels...
By utilizing collaboration between the sending and receiving programs, model described in this article assures that parents do not experience an abrupt cessation of professional support but are supported throughout transition period. A month-by-month timeline for providing services to through three phases is presented. worksheet which can use develop their child's IEP a list parent resources also included. Parent's evaluations provided by indicate they were very satisfied with received.
Co-creation in embodied contexts is central to the human experience but often lacking our interactions with computers. We seek develop a better understanding of co-creativity inform human-centered design machines that can co-create us. In this paper, we ask: What characterizes dancers' experiences dyadic interaction movement improvisation? To answer this, ran focus groups 24 university dance students and conducted thematic analysis their responses. synthesize findings an Interconnected Model...
This paper introduces a new method for quantifying open-ended collaborative embodied improvisation: Observable Creative Sense-Making (OCSM). technique builds on previous work (CSM), examines its shortcomings, and addresses it by reformalizing grounding CSM in current literature from social cognition an intersubjective perspective of creativity. We apply this to empirical studies human collaboration dance improvisation with 16 advanced college dancers establish the method's validity. The OCSM...
In this demonstration, we present a holographic projected version of LuminAI, which is an interactive art installation that allows participants to collaborate with AI dance partner by improvising movements together. By utilizing mix top-down and bottom-up approach, seek understand embodied co-creativity in improvisational setting better develop the design modular agent creatively dancer. The purpose demonstration describe five-module investigate how can immersive experience design-efficient,...
Abstract Background: The systemic treatment of pancreatic cancer (PC) is hindered by the rapid development chemoresistance to current cytotoxic therapies. Mechanisms governing remain poorly characterized, particularly with respect contributions from tumor microenvironment. Thus, goal this study was identify novel mechanisms acting within microenvironment which lead PC chemoresistance. Methods: Intratumoral soluble mediator concentrations resected specimens (n = 26) as well supernatants...
Abstract Smoking is an established risk factor for the development of pancreatic adenocarcinoma (PC). However, relationship between smoking and PC tumor biology incompletely defined. We report reduced overall survival (OS) in patients who continued after surgical resection with curative intention (HR 1.93; P = .040). further demonstrate augmented paracrine signaling via hepatocyte growth (HGF)/c-Met pathway as a result nicotine exposure microenvironment. Specifically, HGF, secreted by...
Abstract The systemic treatment of pancreatic cancer (PC) is hindered by the rapid development chemoresistance to current cytotoxic therapies. Mechanisms governing remain poorly characterized, particularly with respect contributions from tumor microenvironment. Here, intratumoral soluble mediator concentrations resected PC specimens (n=26) as well supernatants co-cultures cell lines and primary tumor-associated stellate cells (PSCs) (n=16) were evaluated using a panel 43 growth factors,...
Abstract Introduction: Pancreatic cancer (PC) is associated with a high rate of cachexia, which specifically diminishes quality life, prohibits effective therapies, and subsequently contributes to morbidity mortality. Unfortunately, mechanisms underlying this cancer-induced muscle wasting in the human disease remain incompletely described, part due limited translational models. Therefore, we hypothesize that development more representative models PC cachexia will allow for therapeutic...
Abstract Pancreatic cancer is the fourth leading cause of deaths in United States and one most difficult-to-treat cancers. Despite advances chemotherapy, 5-year survival following surgical resection only 23% specialized pancreatic surgery centers. A major stumbling block for these other treatments a way to efficiently deliver therapeutics target cells. Thus, we have identified high affinity molecular targeting molecules unique an individual cancer, which were generated utilizing throughput...
<p>Supplemental Figure S2. Nicotine-mediated induction of c-Met is Src-dependent.</p>
<p>Supplemental Figure S1. Induction of c-Met by nicotine occurs at the post-transcriptional level.</p>
<p>Nicotine treatment does not lead to c-Met activation in PC cells.</p>
<div>Abstract<p><b>Purpose:</b> The relationship between smoking and pancreatic cancer biology, particularly in the context of heterogeneous microenvironment, remains incompletely defined. We hypothesized that nicotine exposure would lead to augmentation paracrine growth factor signaling tumor-associated stroma (TAS) cells, ultimately resulting accelerated tumor metastasis.</p><p><b>Experimental Design:</b> effect tobacco use on overall...
<div>Abstract<p><b>Purpose:</b> The relationship between smoking and pancreatic cancer biology, particularly in the context of heterogeneous microenvironment, remains incompletely defined. We hypothesized that nicotine exposure would lead to augmentation paracrine growth factor signaling tumor-associated stroma (TAS) cells, ultimately resulting accelerated tumor metastasis.</p><p><b>Experimental Design:</b> effect tobacco use on overall...
<p>Nicotine treatment does not lead to c-Met activation in PC cells.</p>