A5047715715- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Vascular Tumors and Angiosarcomas
- Hematological disorders and diagnostics
- Advanced biosensing and bioanalysis techniques
- Bladder and Urothelial Cancer Treatments
- Tumors and Oncological Cases
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Soft tissue tumor case studies
- Cardiac tumors and thrombi
- RNA Interference and Gene Delivery
- Gastrointestinal Tumor Research and Treatment
- SARS-CoV-2 detection and testing
- Histiocytic Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Autopsy Techniques and Outcomes
- Immune Response and Inflammation
- CNS Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Sarcoidosis and Beryllium Toxicity Research
University of Louisville
2018-2025
University of Florida
2007-2021
Florida College
2004-2015
Emory University
2015
University of Miami
2015
University of Florida Health
2014
UF Health Shands Hospital
2012-2014
The McCrone Group (United States)
2007
University of Chicago
2007
Harper University Hospital
2007
Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression Th2 polarization. We identify a GR-1+CD11b+ population whose numbers dramatically increase remain elevated in spleen, lymph nodes, bone marrow during polymicrobial sepsis. Phenotypically, these cells are heterogeneous, immature, predominantly myeloid progenitors that express interleukin 10 several other cytokines chemokines. Splenic GR-1+ effectively suppress antigen-specific CD8+ interferon (IFN) γ...
Abstract Bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) can be activated by type I IFNs, TLR agonists, viruses, bacteria to increase hematopoiesis. In this study, we report that endotoxin treatment in vivo induces TLR4, MyD88, Toll/IL-1 resistance domain-containing adaptor-inducing IFN-β (TRIF)-dependent expansion of BM HSPCs. Bacterial infection Staphylococcus aureus or cecal ligation puncture also HSPC expansion, but TRIF, IFN, cytokine, PG, oxidative stress pathways are...
The majority of patients with acute myelogenous leukemia (AML) still die their disease. In order to improve survival rates in AML patients, new strategies are necessary discover biomarkers for the detection and targeted therapy AML. One advantages aptamer-based technology is unique cell-based selection process, which allows us efficiently select cell-specific aptamers without knowing target molecules present on cell surface. NB4 line was used as population selecting single stranded DNA...
Carcinosarcoma is a rare and aggressive malignant neoplasm that predominantly affects elderly postmenopausal women can involve various gynecologic organs. It characterized by the presence of both epithelial sarcomatous components. While most uterine carcinosarcomas (UCS) are homologous (sarcomatous component consisting elements native to uterus), heterologous components less common may vary in composition. Rare include lipomatous (liposarcoma) or osseous (osteosarcoma). We present an unusual...
Acral myxoinflammatory fibroblastic sarcoma (AMIFS) is a low-grade that presents mostly in distal extremities of middle-aged patients. The clinicopathologic features, immunohistochemical profile and follow-up data five cases (three men two women; age 39-65 years) are presented. tumors presented as slow-growing, poorly circumscribed, subcutaneous masses the hands (three), foot (one) calf (one), with dermal involvement cases. They had myxoid hyaline stroma dense acute chronic inflammation....
Abstract Context.—Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported angiosarcomas with variable frequency. In these situations, establishing the diagnosis becomes problematic. Objective.—To determine expression cytokeratin membrane antigen angiosarcoma. Design.—To address this issue, 33 well-documented cases were retrieved from archival material Shands Hospital at University Florida, Gainesville, Jackson Memorial Miami, Florida. These all reviewed...
Abstract Context.—Expression of epithelial cell markers can occur in mesenchymal tumors and has been reported angiosarcomas with variable frequency. In these situations, establishing the diagnosis becomes problematic. Objective.—To determine expression cytokeratin membrane antigen angiosarcoma. Design.—To address this issue, 33 well-documented cases were retrieved from archival material Shands Hospital at University Florida, Gainesville, Jackson Memorial Miami, Florida. These all reviewed...
Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism. A 51-year-old African American female presented with goiter, hyperparathyroidism, and symptomatic hypercalcemia. Sestamibi scan revealed diffuse activity within enlarged thyroid gland uptake in the right lobe suggestive hyperfunctioning tissue. The patient underwent thyroidectomy parathyroidectomy. At exploration, a 2.0 cm nodule usual location inferior was sent for intraoperative frozen...
Bovio I M, Al‐Quran S Z, Rosser C J, Algood B, Drew P A & Allan R W (2010) Histopathology 56, 951–956 Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma Aims: To prospectively evaluate the utility of smoothelin immunohistochemical expression evaluation (MP) diagnostic transurethral resection tumour (TURBT) specimens and cystectomies. Methods results: was performed on total 26 TURBT cystectomy specimens. All but two cases...
Abstract Myeloid sarcoma (MS) of the lower urinary tract is rare. We describe a 47-year-old man with hematuria, who was subsequently found to have MS involving bladder and epididymis. The neoplasm composed predominantly blasts that expressed CD68, CD117, myeloperoxidase, lysozyme, occasional immature eosinophils. Although blood bone marrow examinations showed no morphologic evidence leukemia, conventional cytogenetic studies demonstrated inv(16)(p13q22) in 4 20 metaphases; fluorescence situ...
Myeloid sarcoma (MS) of the lower urinary tract is rare. We describe a 47-year-old man with hematuria, who was subsequently found to have MS involving bladder and epididymis. The neoplasm composed predominantly blasts that expressed CD68, CD117, myeloperoxidase, lysozyme, occasional immature eosinophils. Although blood bone marrow examinations showed no morphologic evidence leukemia, conventional cytogenetic studies demonstrated inv(16)(p13q22) in 4 20 metaphases; fluorescence situ...
Breast cancer is the most prevalent and main cause of cancer-related death in women worldwide. There are limitations associated with existing clinical tools for breast detection alternative modalities early classification urgently needed. Here we describe an optical imaging technique, called multispectral diffuse tomography (DOT), demonstrate its ability non-invasively evaluating nuclear morphometry differentiating benign from malignant lesions. Photon densities along surface were measured...
A 53 year-old African American woman with a three-year history of pulmonary sarcoidosis had follow-up computed tomographic scan to evaluate the status her disease and response treatment. On scan, an abnormal, hypodense mass on left renal superior pole, which was not present previous scans, incidentally discovered. The initial concern carcinoma, despite lack any urinary symptoms. She underwent further evaluation magnetic resonance, enhancement pattern shape were more suggestive lymphoma or...
Systemic capillary leak syndrome (SCLS) is a rare disease characterized by third spacing of plasma into the extravascular compartment, leading to anasarca, hemoconcentration, and hypovolemic shock. It has been rarely associated with lymphomas, reports usually indicate that it occurs after antineoplastic treatment. We present case patient ALK-negative anaplastic large cell lymphoma who presented SCLS as initial manifestation her lymphoma. The resolved treatment malignancy steroids chemotherapy.
Mesenchymal lesions of the breast are uncommon which present diagnostic dilemmas for even most experienced pathologists. Here, we two cases epithelioid-variant myofibroblastoma were misdiagnosed as malignant lesions. Careful integration clinical presentation, imaging, and close examination gross, histologic, immunohistochemical findings can assist in differentiating these challenging avoiding pitfalls.
A 41-year-old female presented with a 2 d history of ‘refusing to talk’ and 1 ‘decreased movement’. She had recent being treated for otitis media, but no malignancy. On admission, full blood count differential white cell were normal. Magnetic resonance imaging revealed 6 cm contrast-enhancing left-sided middle cranial fossa mass extension inferiorly into the subtemporal parapharyngeal space (top left). The radiologist’s diagnosis included meningeal sarcoma, atypical meningioma,...
Aims Natural killer (NK) cell enteropathy is a recently described clinically indolent condition characterised by atypical NK infiltrates in the gastrointestinal mucosa that mimics malignant lymphoma. We report case highlights clinical behaviour documenting absence of progression over 10 years. Methods and results 69‐year old female who had long‐standing abdominal pain recurrent mucosal ulcerations associated with infiltrates. The clinical, morphologic immunophenotypical findings this were...