A5083626143- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Ovarian function and disorders
- Cancer, Hypoxia, and Metabolism
- Autoimmune Neurological Disorders and Treatments
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Cardiac tumors and thrombi
- Oral and Maxillofacial Pathology
- SARS-CoV-2 detection and testing
- Protein Degradation and Inhibitors
- Vascular Tumors and Angiosarcomas
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
Cedars-Sinai Medical Center
2012-2024
Kaiser Permanente West Los Angeles Medical Center
2024
Augusta University
2011-2023
Vanderbilt University Medical Center
2023
USA Mitchell Cancer Institute
2023
University of South Alabama
2023
San Joaquin General Hospital
2023
Kaiser Permanente
2023
Bolan University of Medical and Health Sciences
2023
University of Science and Technology Bannu
2023
Approximately 70% of women with polycystic ovary syndrome (PCOS) have intrinsic insulin resistance (IR) above and beyond that associated body mass, including dysfunctional glucose metabolism in adipose tissue (AT). In AT, analysis the IRS/PI3-K/AKT pathway signaling components identified only GLUT4 expression to be significantly lower PCOS patients control subjects IR. We examined role miRNAs, particularly regulation GLUT4, insulin-sensitive transporter, AT matched subjects. was determined a...
In this study, we demonstrate that a small population of pluripotent stem cells, termed adipose multilineage-differentiating stress-enduring (adipose-Muse) exist in adult human tissue and adipose-derived mesenchymal cells (adipose-MSCs). They can be identified as positive for both MSC markers (CD105 CD90) cell marker SSEA-3. intrinsically retain lineage plasticity the ability to self-renew. spontaneously generate representative all three germ layers from single successfully differentiate...
Advances in stem cell therapy face major clinical limitations, particularly challenged by low rates of post-transplant survival. Hostile host factors the engraftment microenvironment such as hypoxia, nutrition deprivation, pro-inflammatory cytokines, and reactive oxygen species can each contribute to unwanted differentiation or apoptosis. In this report, we describe isolation characterization a new population adipose tissue (AT) derived pluripotent cells, termed Multilineage Differentiating...
Introduction Previous studies highlight a complex relationship between lineage and phenotype for adipose tissue macrophages (ATMs), stem cells (ASCs), adipocytes, suggesting high degree of plasticity these cells. In the present study, using novel co-culture system, we further characterized interaction ATMs, ASCs adipocytes. Research Design Methods Human adipocytes stromal vascular fraction containing ATMs were isolated from human co-cultured 24 hours. FACS was used to characterize before...
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women.Our objective was to compare gene expression pattern sc abdominal adipose tissue nonobese PCOS patients vs. body mass index-matched controls.Eleven subjects and 12 controls (body index 20-28 kg/m(2)) were recruited. Total RNA isolated, profiling performed using Affymetrix Human Genome U133 arrays. Differentially expressed genes classified by ontology. Microarray results for selected confirmed quantitative...
Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of gastrointestinal (GI) system. Most GISTs originate from interstitial cells Cajal (ICC), pacemaker cell situated between circular and longitudinal layers muscularis propria along GI tract. In this population-based study using SEER database, we sought to identify demographic, clinical, pathologic factors that affect prognosis survival patients with neoplasm. Molecular genetic advances, current...
Colorectal cancer (CRC) is a high burden disease with several genes involved in tumor progression. The aim of the present study was to identify, generate and clinically validate novel gene signature improve prediction overall survival (OS) effectively manage colorectal cancer. We explored Cancer Genome Atlas (TCGA), COAD READ datasets (597 samples) from Protein (TPA) database extract total 595 candidate genes. In parallel, we identified 29 perturbations > 6 cancers which are also affected...
Context: Adipose tissue dysfunction associated with low-grade chronic inflammation and dysregulation of adipokine secretion might significantly contribute to the pathogenesis polycystic ovary syndrome (PCOS).
In adipose tissue (AT) micro-RNA-93 (miR-93) is significantly overexpressed in polycystic ovary syndrome (PCOS) women and non-PCOS with insulin resistance (IR). Overexpressed miR-93 directly inhibits glucose transporter isoform 4, impairing both metabolism sensitivity. The mechanisms behind increased expression are unclear.Our objective was to determine whether concordant its host gene, MCM7, which contains the miR-25/93/106b gene cluster.AT excised from 16 PCOS (eight eight without IR) 15...
Renal cell carcinomas (RCC) are heterogeneous and can be further classified into three major subtypes including clear cell, papillary chromophobe. Signal transducer activator of transcription 3 (STAT3) is commonly hyperactive in many cancers associated with cancer proliferation, invasion, migration, angiogenesis. In renal carcinoma, increased STAT3 activation metastasis worse survival outcomes, but clinical trials targeting the signaling pathway have shown varying levels success different...
Background: Salivary gland neoplasms are uncommon in both pediatric and adult populations. Mucoepidermoid carcinoma (MEC) is one of the most common salivary tumors usually presents with atypical clinical features. This study sought to evaluate demographic factors affecting outcomes adults populations MEC that could be used risk stratification for treatment selection trial enrollment. Methods: Data on 4507 patients were extracted from Surveillance Epidemiology End Result (SEER) database...
Digital papillary adenocarcinoma (DPA) is a rare neoplasm that can exhibit local recurrence and distant metastasis. We present series of eight cases DPA showing two distinct clinical presentations, morphologies, immunophenotypes, molecular features. Four were characterized by painless, slow-growing nodules located on the digits. The lesions small, well-defined, confined in dermis. Histopathologically, these tumors composed glandular structures lined cuboidal epithelium with luminal...
In this population-based study, we aim to identify factors that are influential on the survival outcome in MBC and investigate novel molecular approaches personalized disease management.The data of study were collected from SEER database 2000-2018. A total 5315 cases extracted database. The evaluated for demographics, tumor characteristics, metastasis, treatment. Survival analysis was completed by using SAS software multivariate analysis, univariate non-parametric analysis. with most common...
Advances in stem cell therapy face major clinical limitations, particularly challenged by low rates of post-transplant survival.Hostile host factors the engraftment microenvironment such as hypoxia, nutrition deprivation, pro-inflammatory cytokines, and reactive oxygen species can each contribute to unwanted differentiation or apoptosis.In this report, we describe isolation characterization a new population adipose tissue (AT) derived pluripotent cells, termed Multilineage Differentiating...
Primary lung cancer is the most common cause of cancer-related mortality in United States (US). Approximately 90% cancers are associated with smoking and use other tobacco products. Based on histology, divided into small-cell carcinomas (SCLCs) non-small-cell (NSCLCs). Most SCLCs pure subtype, while rare combined contain elements both morphologies. This study sought to evaluate demographics, clinical factors, molecular abnormalities, treatment approaches, survival outcomes SCLC NSCLCs.Data...
Background: Pancreatic lymphomas (PLs) represent <2% of all and <0.5% pancreatic neoplasms. An accurate histologic diagnosis PL is needed to predict prognosis adequately treat the patient. This study aims investigate demographic, clinical, pathological factors affecting survival diffuse large B-cell lymphoma (DLBCL). Methods: Demographic clinical data from 493 cases DLBCL pancreas were identified between 2000 2018 using Surveillance, Epidemiology, End Results (SEER) database. Results:...
Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of cancer. This research aims to present a large database study highlighting demographic, clinical, and pathological factors, racial disparities, prognosis, survival PRCC. The clinical demographic data were extracted from Surveillance, Epidemiology, End Results (SEER) database, molecular was cured Catalogue Of Somatic Mutations in Cancer (COSMIC) database. PRCC had median age diagnosis at 64 years, with...
Background: Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancer (NSCLC) with an aggressive clinical nature and poor prognosis. With novel targeted therapeutics being developed, new ways to effectively treat PSC are emerging. In this study, we analyze demographics, tumor characteristics, treatment modalities, outcomes genetic mutations in PSC. Methods: Data from the Surveillance, Epidemiology, End Results (SEER) database were reviewed cases pulmonary 2000...