A5100741104- Synthesis and Characterization of Heterocyclic Compounds
- DNA and Nucleic Acid Chemistry
- Chemical Reaction Mechanisms
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Ocular Diseases and Behçet’s Syndrome
- Nosocomial Infections in ICU
- Synthesis and Reactivity of Heterocycles
- Nanoparticles: synthesis and applications
- vaccines and immunoinformatics approaches
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- HIV/AIDS drug development and treatment
- Crystallography and molecular interactions
- Autoimmune and Inflammatory Disorders Research
- Synthesis and Biological Evaluation
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Medicinal Plants and Neuroprotection
- interferon and immune responses
- Hibiscus Plant Research Studies
- Psidium guajava Extracts and Applications
Purdue University West Lafayette
2021-2025
University of Rome Tor Vergata
2023-2024
Southend University Hospital NHS Foundation Trust
2024
Government Medical College
2023
Hazara University
2022-2023
Abasyn University
2023
Jinnah Postgraduate Medical Center
2022
Bolan University of Medical and Health Sciences
2022
International Medical University
2022
Monash University Malaysia
2019-2020
Regulators of G protein signaling (RGS) proteins negatively regulate through protein-coupled receptors, and reduced RGS function is involved in numerous pathologies. However, therapeutic intervention challenging, as lack druggable binding pockets enzymatic activity. Instead, targeting mechanisms that control expression show promise an alternative. Pharmacological stabilization RGS2 would be a feasible strategy pathologies associated with levels, such hypertension, heart failure, asthma....
Background: Salivary gland neoplasms are uncommon in both pediatric and adult populations. Mucoepidermoid carcinoma (MEC) is one of the most common salivary tumors usually presents with atypical clinical features. This study sought to evaluate demographic factors affecting outcomes adults populations MEC that could be used risk stratification for treatment selection trial enrollment. Methods: Data on 4507 patients were extracted from Surveillance Epidemiology End Result (SEER) database...
New highly potent and selective 6,<italic>N</italic><sup>2</sup>-diaryl-1,3,5-triazine-2,4-diamines were designed prepared using the 3D-QSAR model developed earlier.
A library of 126 compounds with a 6,N 2-diaryl-1,3,5-triazine-2,4-diamine scaffold was prepared using one-pot, microwave-assisted method from readily available cyanoguanidine, aromatic aldehydes and arylamines. The three-component condensation these reagents in the presence hydrochloric acid followed by treatment base, which promoted rearrangement dihydrotriazine ring its dehydrogenative aromatization. antiproliferative properties were evaluated three breast cancer cell lines. most promising...
The use of natural products isolated from mushrooms against infection, cancer diseases and other oxidative-stress-related is one the cornerstones modern medicine. Therefore, we tried to establish a combination medicinal nanotechnology possibly with field medicine for development antibacterial agents these MDR strains. aim research was understand molecular identification, characterization action Calvatia gigantea Mycena leaiana. identification fruiting body species via morpho-anatomical...
A new, effective one-pot synthesis of the 6,N2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation cyanoguanidine, aromatic aldehydes, and arylamines in presence hydrochloric acid. Without isolation, resulting 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines were treated with a base to initiate Dimroth rearrangement spontaneous dehydrogenative aromatization, affording desired compounds. developed found be...
Dengue infection is a global issue which caused by insect transmitted, positive sense single-stranded RNA dengue virus (DENV). Around 50 million cases of being reported per year whereas population at risk reaches about 2.5 billion in the tropical and subtropical regions world. The present study aimed to develop consensus sequence NS1 protein modelling interaction with various host proteins different cellular pathways. Serotype specific sequences were generated using CLC-Work Bench software....
New potent and selective antileukemic agents were identified in the screening of 94 compounds prepared using a convenient one-pot three-component approach.
1,3,5-Triazine ring is an important scaffold for the construction of new biologically active compounds.Microwave irradiation has found extensive application in organic and medicinal chemistry accelerating reactions drug discovery process.This review systematizes methods microwave-assisted 1,3,5-triazine discusses their advantages disadvantages over based on conventional heating.
Abstract
 Objective: Diabetes mellitus (DM) along with myocardial infarction (MI) carries increased burden on patients in terms of morbidity, mortality and cost. Current study was aimed to investigate the impact DM clinico-laboratory characteristics in-hospital treatment outcomes among MI patients.
 Methodology: All admitted emergency department Faisalabad Institute Cardiology from April, 2016 March, 2017 were recruited into study. The profile without compared using chi-squared...
Tetanus is a fetal disease of human and animals caused by spore forming, Gram-positive, anaerobic bacterium Clostridium tetani.In present report, 16-month old, Beetal buck, weighing about 40 kg was presented to outdoor clinics Department Clinical Medicine Surgery, University Agriculture, Faisalabad, Pakistan with complaint anorexia, abnormal gait gradual loss body condition.History, indicated that animal castrated 12 days before local quack using an ordinary shaving blade.Visual examination...
A convenient one-pot method for the preparation of N 2,6-diaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines was developed using a three-component synthesis 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines followed by their Dimroth rearrangement to desired products. The prepared compounds crystallized from ethanol as clathrates (1 : 1). X-ray crystallography on several products confirmed adoption 5,6-dihydro-tautomer. thermal analysis and powder diffraction experiments selected suggested that...
Abstract A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction presence hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) into targeted compounds via dehydrogenation alkali. tolerated various aldehydes (including heterocyclic) Crystal structures...
Introduction: Timely diagnosis and isolation of cases is paramount importance to contain the spread a pandemic. The Coronavirus Disease-2019 (COVID-19) has emerged as major health problem that needs concerted efforts for mitigation control. Real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR), gold-standard diagnostic modality, high cost can be performed in special laboratories. Rapid Antigen Tests (RAT) been developed serve an alternative recommended use at point-of-care...
The aim of this study was to synthesize and characterize a nanogold-{[(Cu)(phen)(cys)(H2O)]NO3}n conjugate evaluate its antiproliferative property against the breast cancer cell line (MCF7) normal (MCF10A). Nanogold solution prepared using Turkevich method. In one approach, ternary copper(II) complex 1,10-phenanthroline with l-cysteine, [(Cu)(phen)(cys)(H2O)]NO3, first then tethered gold nanoparticles. another nanoparticles were reacted nitrate, subsequently. synthesized...
The polymorphic form results from an interplay between global molecular packing and stability of conformation.
Abstract Background/Aims Juvenile Idiopathic Arthritis (JIA) is the most common inflammatory arthritis in children. Uveitis a (8-30%) and potentially sight-threatening complication of JIA. Early detection treatment uveitis can prevent permanent visual impairment, making screening an essential part management JIA patients. The purpose this audit was to evaluate referral patients our healthcare setting compared with Guidelines for Screening produced jointly by BSPAR RCOphth 2006. Methods...
Pectin, a naturally occurring polysaccharide that has wide range of industrial applications especially in the pharmaceutical industries, recent times gained lot attention by researchers with potential breakthrough as therapeutic agent. The aim this research was to extract, purify and characterize pectin obtained from pulp Parkia biglobosa evaluate its cytotoxic assay on HepG2 cancer cell line. Acidified water (using HNO3 HCl) used for extraction at pH levels 1.5, 3 5. Chemical spectroscopic...
<h3>Objectives</h3> Juvenile Idiopathic Arthritis (JIA) is the most common inflammatory arthritis in children. Uveitis a (8–30%) and potentially sight-threatening complication of JIA.<sup>1</sup> Early detection treatment uveitis can prevent permanent visual impairment, making screening an essential part management. The purpose this audit was to evaluate referral management JIA patients our healthcare setting compared with Guidelines for Screening produced jointly by BSPAR RCOphth 2006....