A5009137307- Hydrogels: synthesis, properties, applications
- Advanced Materials and Mechanics
- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Elasticity and Material Modeling
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Polymer composites and self-healing
- Enzyme Production and Characterization
- Adhesion, Friction, and Surface Interactions
- Silk-based biomaterials and applications
- Semiconductor materials and devices
- Liquid Crystal Research Advancements
- Biofuel production and bioconversion
- Photonic Crystals and Applications
- Copper Interconnects and Reliability
- Collagen: Extraction and Characterization
- Polysaccharides and Plant Cell Walls
- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Tribology and Wear Analysis
Hokkaido University
2016-2025
Japan Science and Technology Agency
2021-2022
Sapporo Science Center
2015-2020
Life Science Institute
2019
Advanced Life Science Institute
2015-2018
Toyohashi University of Technology
2018
Collaborative Research Group
2016-2017
National Institute of Standards and Technology
2010
Kanagawa Institute of Technology
2003
Tohoku University
1984-2002
Working harder, getting stronger Self-healing polymers attempt to restore mechanical strength after deformation. Polymer gels tend be too soft for this occur. Matsuda et al. generated self-healing hydrogels composed of a double-network material (see the Perspective by Craig). A stress breaks more brittle two networks, while other retains stability. On breakage, fractured chains create radical initiators that polymerize new network material. With repeated breakage and supply monomers, gel...
A series of tough polyion complex hydrogels is synthesized by sequential homopolymerization cationic and anionic monomers. Owing to the reversible interpolymer ionic bonding, materials are self-healable under ambient conditions with aid saline solution. Furthermore, self-glued bulk can be built from their microgels, which promising for 3D/4D printing additive manufacturing hydrogels. As a service our authors readers, this journal provides supporting information supplied authors. Such peer...
A series of physical double-network hydrogels is synthesized based on an amphiphilic triblock copolymer. The gel, which contains strong hydrophobic domains and sacrificial dynamic bonds hydrogen bonds, stiff tough, even stiffens in concentrated saline solution. Furthermore, due to its supramolecular structure, the gel features improved self-healing self-recovery abilities.
Abstract Natural structural materials (such as tendons and ligaments) are comprised of multiscale hierarchical architectures, with dimensions ranging from nano‐ to macroscale, which difficult mimic synthetically. Here a bioinspired, facile method fabricate anisotropic hydrogels perfectly aligned fibrous structures similar those ligaments is reported. The includes drying diluted physical hydrogel in air by confining its length direction. During this process, sufficiently high tensile stress...
We elucidate why the anomalous high strength of double network gels is obtained when second polymerized without any cross-linkers. have synthesized truly independent-DN (named "t-DN" gels), which do not covalent bonds between first and networks, showed that t-DN cannot be toughened by un-cross-linked network. It means usual DN cross-linker actually achieved interconnection two networks through (so were named "c-DN" gels). Further, we found become stronger than c-DN loosely cross-linked. As a...
On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates the gel matrix owing to semi-permeablility hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding bone. This is first success in realizing robust osteointegration hydrogels, and method simple feasible for practical use. Recent progress developing hydrogels has made these highly water-containing materials promising substitutes soft...
Previously we revealed that the high toughness of double network hydrogels (DN gels) derives from internal fracture brittle during deformation, which dissipates energy as sacrificial bonds. In this study, intend to elucidate detailed process DN gels. We quantitatively analysed tensile hysteresis and re-swelling behaviour a gel shows well-defined necking strain hardening, obtained following new findings: (1) 1st PAMPS starts far below yielding strain, 90% initially load-bearing chains already...
Recently, polyampolytes have been discovered to form hydrogels that possess high toughness, full resilience, and self-healing between two cut surfaces. The of this class is based on the re-forming multiple ionic bonds at fractured surfaces, in which mobility polymer segments strength play an important role. In work, we study effects healing temperature chemistry polyampholyte (chemical cross-linker density chemical structure monomers) kinetics efficiency. substantially accelerates kinetics....
Developing nonspecific, fast, and strong adhesives that can glue hydrogels biotissues substantially promotes the application of as biomaterials. Inspired by ubiquitous adhesiveness bacteria, it is reported neutral polyampholyte hydrogels, through their self-adjustable surface, show rapid, strong, reversible adhesion to charged biological tissues Coulombic interaction.
Abstract Living organisms share the ability to grow various microstructures on their surface achieve functions. Here we present a force stamp method of hydrogels based force-triggered polymerisation mechanism double-network hydrogels. This allows fast spatial modulation morphology and chemistry hydrogel within seconds for on-demand We demonstrate oriented growth cells directional transportation water droplets engineered surfaces. chemically engineer surfaces provides new tool in addition...
Abstract Double‐network hydrogels (DN gels), despite their high water content, are the strongest and toughest soft wet materials available. However, in conventional DN gels, which show extraordinarily mechanical performance comparable to that of industrial rubbers, first network must be a strong polyelectrolyte this requirement greatly hinders widespread application these gels. A general method involving use “molecular stent” for synthesis tough gels using any hydrophilic polymer as is...
Novel, tough, strong, and self-healable poly-acrylamide (PAAm) gels are fabricated by inducing an appropriate phase-separation structure using a poor solvent. The phase separation induces gel-glass-like transition of the PAAm gels, providing anomalously high modulus (211 MPa), fracture stress (7.13 energy (4.16 × 10(4) J m(-2)), while keeping solvent content (≈60 vol%).
Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from components proteoglycan aggregates – chondroitin sulfate proteoglycans (1), (2), and sodium hyaluronate (3) are successfully developed in combination with neutral biocompatible polymer. This work demonstrates promising method to create biopolymer-based for biomedical applications.
A lamellar hydrogel with high toughness, exhibiting ternary stimuli-responsive structural color changes has been synthesized. The gel consists of alternating hard layers a polymeric surfactant (PDGI) and soft interpenetrating networks poly(acrylamide)-poly(acrylic acid). Reversible, wide range switching the stop-band position was achieved using different external stimuli temperature, pH, stress/strain.
Double network (DN) gels, consisting of a brittle first and flexible second network, have been known to be extremely tough functional hydrogels. In DN gel subjected force, the breaks prior fracture network. This process, referred as internal fracture, dissipates energy increases required completely gels. Such macroscopically appears yielding-like phenomenon. The aim this paper is investigate relationship between yield point molecular structure gels more deeply understand mechanism To achieve...
Tough hydrogels have shown strong potential as structural biomaterials. These alone, however, possess limited mechanical properties (such low modulus) when compared to some load‐bearing tissues, e.g., ligaments and tendons. Developing both tough soft materials is still a challenge. To overcome this obstacle, new material design strategy has been recently introduced by combining with woven fiber fabric create reinforced composites (FRSCs). The FRSCs exhibit extremely high toughness tensile...
Recently, we have reported that polyampholytes, synthesized from free radical copolymerization of anionic monomer and cationic monomer, form physical hydrogels high toughness self-healing. The random distribution the opposite charges forms ionic bonds a wide strength. strong serve as permanent cross-links, imparting elasticity, whereas weak serves reversible sacrificial by breaking reforming to dissipate energy. In this work, focus on rupture behaviors polyampholyte hydrogel,...
In this work, the mechanical behavior of sparsely cross-linked, neutral polyacrylamide (PAAm) hydrogels containing densely cross-linked polyelectrolyte microgels poly(2-acrylamido-2-methylpropanesulfonic sodium) (PNaAMPS) were studied systematically by varying formulations. The microgel-reinforced (MR) have a two-phase composite structure, where disperse phase is rigid double-network (DN) microgels, and continuous soft PAAm matrix. At optimal formulation, MR gels showed high strength...
Recently, many tough and self-healing hydrogels have been developed based on physical bonds as reversible sacrificial bonds. As breaking re-forming of are time-dependent, these viscoelastic the deformation rate temperature pronouncedly influence their fracture behavior. Using a polyampholyte hydrogel model system, we observed that time–temperature superposition principle is obeyed not only for small strain rheology but also large hysteresis energy dissipation below certain temperature. The...
Recently, charge balanced polyampholytes (PA) have been found to form tough and self-healing hydrogels. This class of physical hydrogels a very high equilibrated polymer concentration in water (ca. 40-50 wt%), are strongly viscoelastic. They synthesized by random copolymerization equal amounts oppositely charged monomers at concentration, followed dialysis process the small counter-ions co-ions water. The randomly distributed, opposite charges multiple ionic bonds intra- inter-chains with...