A5033090528- Clinical Laboratory Practices and Quality Control
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Chemokine receptors and signaling
- Proteoglycans and glycosaminoglycans research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Atherosclerosis and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Quality and Safety in Healthcare
- Venous Thromboembolism Diagnosis and Management
- Metabolism and Genetic Disorders
- Biosensors and Analytical Detection
- Acute Myocardial Infarction Research
- Systemic Sclerosis and Related Diseases
- Pharmacological Effects and Toxicity Studies
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Immune Response and Inflammation
- Diabetes Management and Research
- Immune cells in cancer
- HIV Research and Treatment
- Tea Polyphenols and Effects
- Allergic Rhinitis and Sensitization
- Inflammatory Myopathies and Dermatomyositis
Temple University
2010-2024
Temple University Health System
2024
Louisiana State University Health Sciences Center Shreveport
2024
ENT and Allergy
2024
Albany Medical Center Hospital
2018
King Fahd University of Petroleum and Minerals
2018
Temple University Hospital
2017
The University of Texas Southwestern Medical Center
2005-2008
Southwestern Medical Center
2006
University of Calgary
2003-2005
Abstract Lymphocyte CD44 interactions with hyaluronan localized on the endothelium have been demonstrated to mediate rolling and regulate lymphocyte entry into sites of chronic inflammation. Because neutrophils also express CD44, we investigated role in multistep process neutrophil recruitment. CD44−/− wild-type control mice were intrascrotally injected neutrophil-activating chemokine, MIP-2, leukocyte kinetics cremasteric microcirculation 4 h subsequently using intravital microscopy....
Sepsis is the systemic response to infection by microbial organisms. A differential diagnosis of caused either bacteria or other organisms essential for effective treatment and prognostic assessment. Current clinical laboratory methods in bacterial infections are non-specific require longer turnaround times. Procalcitonin (PCT) a biomarker that exhibits greater specificity than proinflammatory markers (eg, cytokines) identifying patients with sepsis can be used infections. In this article,...
As the COVID-19 pandemic rages on, new SARS-CoV-2 variants have emerged in different regions of world. These newly mutations their spike (S) protein that may confer resistance to vaccine-elicited immunity and existing neutralizing antibody therapeutics. Therefore, there is still an urgent need safe, effective, affordable agents for prevention/treatment its variant infection.We demonstrated green tea beverage (GTB) or major ingredient, epigallocatechin gallate (EGCG), were highly effective...
Abstract Context.—Point-of-care testing glucose meters are strongly recommended in the management of diabetes and increasingly being used for making therapeutically important decisions. Thus, it is essential that their results correlate well with those laboratory analyzers. Objectives.—To test reliability point-of-care meters. Design.—Two studies were performed: (1), an in-house study comparing accuracy a reference analyzer using fresh whole blood specimens (2), real-time comparison (a) 2...
Abstract The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Point-of-Care Testing (C-POCT) supports the use point-of-care testing (POCT) outside hospital setting performed by healthcare professionals without formal laboratory education because its numerous benefits. However, these benefits are associated with risks that must be managed, to ensure provision reliable test results minimize harm patient. Healthcare professionals, local regulatory...
Acetaminophen toxicity is the most common form of acute liver failure in U.S. After acetaminophen overdoses, quantitation plasma can aid predicting severity injury. However, recent case reports have suggested that concentrations may be falsely increased presence hyperbilirubinemia.We tested sera obtained from 43 patients with failure, mostly unrelated to acetaminophen, utilizing 6 different systems determine significance this effect. In 36 samples bilirubin ranging 1.0-61.5 mg/dl no was...
ABSTRACT In sepsis, and in models of sepsis including endotoxemia, impaired neutrophil recruitment chemotaxis have been reported. The inability the endotoxemic to chemotax could be attributed fact that intracellular signaling via LPS overrides signals from endogenous chemokines or, alternatively, sequestration neutrophils into lungs prevents access peripheral tissues. Using both vitro vivo assays authors established healthy mice chemotaxed toward MIP‐2, whereas did not. Since activates...
Abstract Evidence indicates that the lentivirus, HIV, infection affects neutrophil response to bacteria and bacterial products in vitro. We used a novel model of rapid onset immunosuppression following with similar feline immunodeficiency virus (FIV), cats examine function within microvasculature vivo determine steps are impaired recruitment cascade. In uninfected infected neonatally FIV, mesentery was exteriorized, but remained autoperfused during intravital microscopy for 4 h. When tissue...
Background: The normally acidic skin pH changes in atopic dermatitis (AD) to alkaline, which contributes the associated skin-barrier dysfunction. Hence, cleansers would be preferred, but such information is scarce. Objective: Guiding health-care providers and patients on selecting with a optimal for AD. Methods: A total of 250 products were tested: 37 soaps (32 bars, 5 liquid) 213 syndets (14 199 liquid); 10% solutions tested by using meter; values 6.65‐7.35 considered neutral. Results:...
Recombinant hirudin (r-hirudin) is being used increasingly for therapeutic anticoagulation in patients with heparin-induced thrombocytopenia undergoing cardiovascular surgery. Although multiple laboratory methods are available measuring r-hirudin, the ecarin clotting time (ECT) most commonly this purpose. Ecarin (extracted from snake venom) converts prothrombin to meizothrombin, which promotes clot formation. Direct thrombin inhibitors, like bind meizothrombin and yield a linear,...
Abstract As the COVID-19 pandemic rages on, new SARS-CoV-2 variants have emerged in different regions of world. These newly mutations their spike (S) protein that may confer resistance to vaccine-elicited immunity and existing neutralizing antibody therapeutics. Therefore, there is still an urgent need safe, effective, affordable agents for prevention/treatment its variant infection. Here, we demonstrated green tea beverage (GTB) or major ingredient, epigallocatechin gallate (EGCG), were...
The female reproductive tract (FRT) is a major site of HIV sexual transmission. As the outermost layer cells in FRT, human cervical epithelial (HCEs) have direct contact with or infected cells. Our early work showed that supernatant (SN) from TLR3-activated HCEs contain antiviral factors could potently inhibit replication macrophages. However, it remains to be determined how transport anti-HIV This follow-up study examined role exosomes HCE-mediated activity. We found TLR3 activation...
Because the vaccine-elicited antibody and neutralizing activity against spike protein of SARS-CoV-2 are associated with protection from COVID-19, it is important to determine levels specific IgG neutralization titers elicited by vaccines. While three widely used vaccine brands (Pfizer-BNT162b2, Moderna-mRNA-1273 Johnson-Ad26.COV2.S) effective in preventing infection alleviating COVID-19 illness, they have different efficacy COVID-19. It unclear whether differences due varying ability...