A5100754566- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- T-cell and B-cell Immunology
- Cardiac Valve Diseases and Treatments
- Metabolism and Genetic Disorders
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Ophthalmology and Eye Disorders
- Adipose Tissue and Metabolism
- Retinal Diseases and Treatments
- ATP Synthase and ATPases Research
- Systemic Lupus Erythematosus Research
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Facial Trauma and Fracture Management
- Traditional Chinese Medicine Studies
- HVDC Systems and Fault Protection
Sun Yat-sen University
2021-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2021-2025
Second People’s Hospital of Yibin
2024-2025
Tsinghua University
2023-2025
East China Normal University
2025
China Medical University
2024
Nantong University
2013-2024
Affiliated Hospital of Nantong University
2013-2024
Second Affiliated Hospital of Nantong University
2017-2024
Shaanxi Provincial People's Hospital
2023-2024
Background Epidemiological studies have revealed a link between inflammatory bowel disease (IBD) and hidradenitis suppurativa (HS). To determine whether IBD HS are causally related, we used the Mendelian randomization (MR) approach. Methods A two-sample MR was performed using an analysis of 12,882 patients 21,770 controls with its main subtypes, ulcerative colitis (UC) Crohn’s (CD). total 409 cases 211,139 without (HS) were included in data for this condition from various GWAS...
Abstract Osteomyelitis is a bone destructive inflammatory disease caused by infection. Ferroptosis closely related to multiple diseases, but the role of ferroptosis in Staphylococcus aureus (SA)‐induced osteomyelitis remains unknown. In present study, we found that SA treatment promoted accumulation iron, Fe 2+ , lipid peroxide, and malondialdehyde, increased TFRC reduced FTH1 GPX4 trigger rat marrow mesenchymal stem cells (BMSCs). Interestingly, level N6 methyl adenosine (m6A) modification...
The HIV/AIDS surveillance data indicates that the proportion of people living with (PLWHAs) who were 50 years old or older increased to 42.7% in 2011 from 16.5% 2007 Nanning, capital city Guangxi Province. A greater number newly diagnosed HIV cases compared clinical AIDS identified adults. dominant transmission mode among PLWHAs was heterosexual although approximately 30% all acquired through contacts.
DC transmission technology is an efficient solution to address the challenge of transmitting large-scale offshore wind power. Prevailing projects generally adopt AC collection - scheme. However, there are concerns about voltage/reactive power and synchronous stability on side. To achieve cheaper more generation, this article proposes a plan for series transmission. It analyses coupling characteristics stable control tactics all-DC system highlights essential role voltage-regulating converter...
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation in synovial joints and influenced genetic environmental factors. The immune system, comprising various cells that either exacerbate or reduce inflammation, plays central role RA pathogenesis. Despite extensive research, the causal relationships between cell phenotypes remain unclear. We employed two-sample Mendelian randomization (MR) approach to investigate associations 731 RA. Genetic...
DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG glycosylase1 (hOGG1) a key enzyme in base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested hOGG1 Ser326Cys polymorphism (rs1052133) associated with many diseases. The purpose this investigation was investigate whether human BER genetic susceptibility NIHL Chinese population. This...
Background Few studies have investigated the relationship between HIV-related stigma and quality life at dyadic level. The objective of this study was to examine actor partner effects that perceived by people living with HIV/AIDS (PLWHAs) caregivers on Method A survey conducted among 148 dyads consisting one PLWHA caregiver (296 participants) in Nanning, China. interdependent a pair members influences associations analyzed, using an innovative analysis technique: Actor-Partner...
Background: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects the efficacy of is not satisfying. Currently, laser treatment has been studied for its in onychomycosis. Our study was aimed evaluate fractional carbon dioxide (CO2) combined with terbinafine cream 6 months onychomycosis analyze influencing factors. Methods: A total 30 participants (124 nails) clinical mycological diagnosis received CO2 at 2-week...
Abstract Anemia is a significant complication of chronic inflammation and may be related to dysregulated activities among erythroblastic island (EBI) macrophages. GM-CSF was reported upregulated attracted as therapeutic target in many inflammatory diseases. Among EBIs, we found that the receptor preferentially highly expressed EBI macrophages but not erythroblasts. treatment significantly decreases human formation vitro by decreasing adhesion molecule expression CD163. RNA-sequence analysis...
Antibody–drug conjugates (ADCs), integrating high specificity of antigen-targeting antibodies and potency cell-killing chemical drugs, have become one the most rapidly expanding therapeutic biologics in oncology. Although ADCs were widely studied from multiple aspects, overall structural elucidation with comprehensive understanding variants is scarcely reported. Here, for first time, we present a holistic in-depth characterization an interchain cysteine-conjugated ADC, focusing on...
Current studies have indicated that long non-coding RNAs (lncRNAs) could act as tumor biomarkers for disease diagnosis and prognosis prediction. In this study, we mainly focused on determining the expression of circulating lncRNAs in patients suffering hilar cholangiocarcinoma (HC), aiming to reveal potential lncRNA a fingerprint.A total 12 were previously proven be aberrantly expressed HC tissues. All selected candidate targets subsequent assay. The validated by qRT-PCR arranged training...
Background: Small nucleolar RNA host gene ( SNHG ) family members are newly recognized lncRNAs, which have been revealed to be oncogenes in several cancers. However, little studies investigated the expression and clinical implications of SNHGs AML. Methods: Herein, we systemically determined prognostic role acute myeloid leukemia (AML). Results: Among all members, identified that only SNHG7 SNHG12 were found effects on overall survival (OS) leukemia-free (LFS) AML by Cox regression...
This study aimed to investigate the effects of pulse pressure (PP) on cognition and role white matter lesions (WMLs) in mediating this association. We enrolled 3,009 participants from SPRINT-MIND study. Of those, 755 underwent brain magnetic resonance imaging. Cognitive tests were summarized five domains, including global cognition, executive function, attention, memory, language. Multiple linear regression models employed analyze PP association with mediation analysis was applied determine...
Genome-wide association study (GWAS) analysis identified three new susceptibility loci for PACG. In this study, we aimed to investigate whether these in PLEKHA7, COL11A1, and PCMTD1-ST18 are associated with PAC ocular biometric characteristics, such as axial length (AL), anterior chamber depth (ACD), diopter of spherical power (DS). The was a part the Jiangsu Eye Study. samples were collected from 232 subjects 306 controls population-based prevalence survey conducted Funing County Jiangsu,...