A5100659191- MicroRNA in disease regulation
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- Circular RNAs in diseases
- Polyomavirus and related diseases
- Cancer-related molecular mechanisms research
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Inflammasome and immune disorders
- Air Quality and Health Impacts
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Neurological Complications and Syndromes
- Connective Tissue Growth Factor Research
- Climate Change and Health Impacts
Anhui Medical University
2016-2025
First Affiliated Hospital of Anhui Medical University
2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
University of Science and Technology of China
2018-2023
Ministry of Education of the People's Republic of China
2019-2023
Shandong University of Traditional Chinese Medicine
2023
The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome plays pivotal roles in inflammation and autoimmunity. NLRP3 is activated response to various signals, including pathogen-associated molecular patterns (PAMPs) danger-associated (DAMPs). However, its role remains unclear. In this study, we used lipopolysaccharide (LPS) adenosine triphosphate (ATP) simulate an inflammatory environment as the testing model. We found that exposure of RAW264.7 cells LPS/ATP triggered...
Abstract Cancer related inflammation (CRI) is now recognized as the seventh hallmark in pathogenesis of many types malignancies. Paeonol, a natural phenolic component isolated from root bark Paeonia moutan , has significant anti‐inflammatory activity. Recently, accumulating body research revealed potent anti‐tumor effects mediated by paeonol. However, little known about its anticancer mechanism on basis CRI. In this study, we observed that paeonol exerted direct activity through inhibition...
MicroRNAs (miRNAs) are involved in the pathogenesis of various human cancers. Here we show that miR-145 expression is decreased glioma samples, rat tissues, and cell lines, while BNIP3 increased. Over-expression or suppression induced apoptosis. localized nucleus cells, inhibits by binding to 3' untranslated region its mRNA. Interestingly, regulate apoptosis modulating Notch signaling. These results indicate increases inhibiting signaling, suggest may serve as a novel therapeutic target for...
Abstract Activation of Kupffer cells (KCs) plays a central role in the pathogenesis alcoholic liver disease (ALD). C57BL/6 mice fed EtOH-containing diet showed mixed induction hepatic classical (M1) and alternative (M2) macrophage markers. Since telomerase activation occurs at critical stages myeloid lymphoid cell activation, we herein investigated reverse transcriptase (TERT), determining factor telomerase, during ALD. In our study, TERT expression activity (TA) were remarkably increased...
Objective: This study aimed to investigate the effect of rapamycin on inflammatory pain in rats. Introduction: Inflammatory is a kind pathological caused by mediators or factors such as TNF-α (Tumor Necrosis Factor-α), IL-1β (Interleukin-1β), and IL-6 (Interleukin-6). NSAIDs opioid analgesics are commonly used for relieving pain, but side effects limit their clinical application. New drugs based new mechanisms urgently needed. Autophagy an evolutionarily conserved homeostatic process...
The purpose of this study was to determine the species distribution and monitor antifungal susceptibility profiles clinical Candida isolates collected in China from 2009 2013.The susceptibilities 952 were tested.Candida albicans most common species, accounting for 65.7% total isolates. frequently isolated non-albicans glabrata (193, 20.3%). Nearly 7.6%, 3.2%, 1.8%, 1.1% exhibited decreased fluconazole, voriconazole, itraconazole, flucytosine, respectively. Moreover, seven C. one krusei had...
Background: Targeting inflammatory microenvironment is a promising anti-tumor strategy. Paeonol phenolic compound with effective anti-inflammatory and properties. However, the effects of paeonol on non-small cell carcinoma (NSCLC) have not been fully investigated. Here, we evaluated proliferation metastasis NSCLC elucidated underlying mechanisms. Methods: The cytokines were determined by ELISA assays. Assays wound healing, single migration perforation invasion used to evaluate cells....
Rheumatoid arthritis (RA) is characterized by tumor-like expansion of the synovium and subsequent destruction adjacent articular cartilage bone. The latest studies proved phosphatase tension homolog deleted on chromosome 10 (PTEN) might contribute to surviving, proliferation pro-inflammatory cytokines in RA. purpose this study was explore function underlying mechanisms PTEN RA chemokines fibroblast-like synoviocytes (FLSs). Increased level observed adjuvant-induced (AIA) FLSs comparison...
Abstract Background Interpregnancy interval (IPI) is associated with a variety of adverse maternal and infant outcomes. However, reports its associations early neurodevelopment are limited the mechanisms this association have not been elucidated. Maternal–fetal glucose metabolism has shown to be neurodevelopmental. The objective study was determine whether plays role in relationship between IPI neurodevelopment. Methods This prospective birth cohort included 2599 mother-infant pairs....
CircRNAs (circRNAs) are commonly dysregulated in a variety of human diseases and involved the development progression cancer. However, role circRNAs hepatic fibrosis (HF) is still unclear. Our previous high throughput screen revealed changes many mice with carbon tetrachloride (CCl4)-induced HF. For example, circCREBBP was significantly down-regulated primary stellate cells (HSCs) liver tissue HF induced by CCl4 compared to those vehicle group. Overexpression AAV8-circCREBBP vivo prevented...
Abstract Lung cancer is the with highest mortality, and non‐small cell lung (NSCLC) accounts for more than 80%. Tumor cells often have high reactive oxygen species (ROS) antioxidant capacity. Redox balance very important tumor. The decline of capacity excessive ROS will induce death tumor cells. Destroying redox a promising treatment strategy. Xanthatin an active sesquiterpene lactone isolated from Xanthium strumarium L. We observed that xanthatin induced up regulation mitochondrial damage....
Background: The shortage of primary medical staff is a major problem in the management health human resources across many developing countries. By determining their preferences for various motivational and related factors, we examined correlation between staff's motivation preference levels turnover intention. This study aimed to further improve incentive mechanism provide reference healthcare managers formulate strategies team. Methods: A self-reported questionnaire survey was conducted...