A5016280499- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Health and Wellbeing Research
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Antimicrobial Resistance in Staphylococcus
- Folate and B Vitamins Research
- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced organ toxicity mitigation
- Microbial Metabolism and Applications
- Chronic Kidney Disease and Diabetes
- NF-κB Signaling Pathways
- Phytochemistry and biological activity of medicinal plants
- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- PARP inhibition in cancer therapy
- Diabetes Management and Research
- Pharmacy and Medical Practices
- Nausea and vomiting management
- Barrier Structure and Function Studies
- Saffron Plant Research Studies
- Streptococcal Infections and Treatments
University of Science and Technology of China
2018-2024
Anhui Provincial Hospital
2005-2022
Anhui Medical University
2008-2018
Abstract Cancer related inflammation (CRI) is now recognized as the seventh hallmark in pathogenesis of many types malignancies. Paeonol, a natural phenolic component isolated from root bark Paeonia moutan , has significant anti‐inflammatory activity. Recently, accumulating body research revealed potent anti‐tumor effects mediated by paeonol. However, little known about its anticancer mechanism on basis CRI. In this study, we observed that paeonol exerted direct activity through inhibition...
Immunoglobulin superfamily (IgSF) members are known for their role as glycoproteins expressed on the surface of immune cells, enabling protein-protein interactions to sense external signals during responses. However, functions immunoglobulins localized within subcellular compartments have been less explored. In this study, we identified an endoplasmic reticulum (ER)-localized immunoglobulin, IgSF member 6 (IgSF6), that regulates ER stress and inflammatory response in intestinal macrophages....
Bleeding is the most common adverse reaction to aspirin and can lead drug discontinuation or even be life-threatening in secondary prevention of stroke transient ischemic attack. The aim this study was evaluate risk factors for bleeding attack.This retrospective analysis included patients treated with (100 mg) as a events that occurred during first year were collected, including gastrointestinal, skin, nasal cavity, gum, urinary tract events. Then, univariate multivariate logistic regression...
Penta-acetyl geniposide ((Ac)<sub>5</sub>GP), an herbal derivative prepared from Gardenia Fructus geniposide, decreased the DNA damage and hepatocarcinogenesis induced by aflatoxin B1 (AFB1). The present study was carried out to further evaluate protective effect of (Ac)<sub>5</sub>GP on liver injury D-galactosamine (D-GalN). D-GalN (400 mg/kg) given mice intraperitoneal injection, while were orally administered gastric gavage. Spectrophotometrical method used measure activities aspartate...
Objective: To investigate the availability, prices and affordability of essential medicines in pediatric population across China, hope improving rational use medicines. Methods: A multicenter cross-sectional survey medicine prices, availability was conducted 17 provinces, municipalities autonomous region east, south-central part, west north China. Data on 42 used population, both original generic, were collected 55 public hospitals from May 26 to June 2, 2017. Availability expressed as...
This study established an individualized nomogram for predicting the risk of multidrug-resistant bacterial (MDRB) infection in patients with diabetic foot (DF), and providing a reference clinical prevention treatment.A total 199 DF admitted to hospital from July 2015 December 2018 were included this study. The pathogenic bacteria at site detected factors affecting occurrence MDRB summarized. R software was used draw nomogram, Bootstrap Method internally verify model. calibration curve...
Background This study used single-center analysis of human serum albumin clinical usage and enteral-parenteral nutritional support to establish application standards for the rational use albumin. Methods A total 1984 patients receiving were enrolled in this retrospective analyze support. Results Among patients, 1044 (52.6%) found have irrational applications use. Major indications hypoproteinemia (30.0%) (21.9%). Surgical departments including thoracic surgery, orthopedics, neurosurgery had...
Objective To evaluate the relationship between MTHFR C677T and A1298C gene polymorphism adverse reactions of blood system induced by methotrexate (MTX). Methods The databases PubMed, Science Direct, Web Science, CNKI, VIP, Wanfang Database from inception to August 2015 were searched. The reports about MTX quality enrolled articles evaluated according Strengthening Reporting Genetic Association Studies(STREGA). software Review Manager 5.3 was used for Meta-analysis. results expressed...