A5054712138- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Childhood Cancer Survivors' Quality of Life
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- ATP Synthase and ATPases Research
- Autoimmune and Inflammatory Disorders Research
- RNA Research and Splicing
- Hemophilia Treatment and Research
- Hematological disorders and diagnostics
- Transplantation: Methods and Outcomes
- Sepsis Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Viral Infections and Vectors
- Cardiac electrophysiology and arrhythmias
- Tuberous Sclerosis Complex Research
- Eicosanoids and Hypertension Pharmacology
Ningbo University
2018-2022
Xuzhou Children Hospital
2016-2021
Xuzhou Medical College
2019-2020
Huazhong University of Science and Technology
2012
University of Toronto
2008
Dalhousie University
2008
Diagnostic Services Manitoba
2008
Ministry of Health
2008
Alberta Health Services
2008
Saskatchewan Health Authority
2008
Increasing evidence suggests that the renin-angiotensin system modulates cardiovascular homeostasis both via its circulating, plasma-borne components and through locally present, tissue-resident systems with site-specific activity. The existence of such a in heart has been proposed, based on biochemical studies as well demonstration renin angiotensinogen messenger RNA cardiac tissue. We conducted present study to determine whether biologically active angiotensin peptides may be cleaved...
The health problems related to the nervous system are on rise in young infants leading high mortality amongst this age group. A chronic medical condition (CC) is present group tune of 10-20%. We searched electronic database PubMed for pre-clinical as well clinical controlled trials reporting variable conditions especially pediatric patients. Most these reports revealed that type 1 diabetes mellitus most common CC infants. In female patients, metabolic control often disturbed during Poor...
Cisplatin resistance is a major obstacle in the treatment of lung adenocarcinoma (LAD), and its mechanism has not been fully elucidated. Here, we report that miR-326 downregulated cisplatin-resistant A549/CDDP cells compared with parental A549 cells. Overexpression reversed cisplatin chemoresistance LAD vitro vivo. Moreover, identified specificity protein 1 (SP1) gene as novel direct target miR-326. Knockdown SP1 revealed similar effects ectopic expression. Decreased expression was also...
Red blood cell distribution width (RDW) is associated with increased mortality risk in patients chronic obstructive pulmonary disease (COPD). However, limited data are available for critically ill COPD.
Reduced doses of emicizumab improve the affordability among patients in developing countries. However, relationship between variant dose selection and efficacy real world China is still unclear.
Osteosarcoma is the most common primary malignant bone tumor type in children and adolescents under 20 years of age. Biological characteristics include invasiveness, metastasis, abnormal differentiation loss contact inhibition. microRNAs (miRNAs) are involved transcriptional post-transcriptional regulation target mRNAs. Previous studies have demonstrated that miR-218 inhibits formation progression glioma, colon cancer renal cell carcinoma; however, mechanism action osteosarcoma has not been...
Multidrug resistance (MDR) is the primary barrier to success of chemotherapy for lung adenocarcinoma. MicroRNA (miR)-134, which downregulated in adenocarcinoma, influences cell proliferation, apoptosis and invasion However, function miR-134 MDR adenocarcinoma remains unclear. In present study, it was identified that expression significantly A549/cisplatin cells, as compared with A549 parental cells. regulates sensitivity cells certain anticancer drugs. Furthermore, demonstrated forkhead box...
The ubiquitin ligase ring finger protein 5 (RNF5) has previously been associated with the development of breast cancer. Patients cancer and high RNF5 expression have demonstrated to a shorter survival time compared patients low expression. However, role in human glioma not determined. present study analyzed gliomas using bioinformatics analysis. results revealed that was differentially expressed non-cancerous brain tissues different grades glioma. Furthermore, an improved prognosis Gene Set...
Gliomas are the most common primary brain tumors. Because of their high degree malignancy, patient survival rates unsatisfactory. Therefore, exploring glioma biomarkers will play a key role in early diagnosis, guiding treatment, and monitoring prognosis gliomas. We found two lncRNAs, six miRNAs, nine mRNAs that were differentially expressed by analyzing genomic data patients. The diagnostic value mRNA expression levels gliomas was determined receiver operating characteristic (ROC) curve...
Abstract Rationale: Childhood chronic myeloid leukemia (CCML) is a malignant disease of granulocyte abnormal hyperplasia that caused by clonal proliferation pluripotent stem cells. The condition relatively rare, accounting for 2.0% to 3.0% cases childhood leukemia. In addition, the incidence extramedullary blast crisis in CCML presenting as central nervous system (CNS) remaining phase bone marrow extremely unusual. Patient concerns: We report case myelogenous abandoned treatment, resulting...
The aim of the study is to investigate association interferon gamma (IFN-γ) and interleukin-10 (IL-10) gene single nucleotide polymorphisms with susceptibility hemophagocytic lymphohistiocytosis (HLH) in Chinese children without known family history HLH.Forty HLH 160 age- gender-matched healthy controls from Xuzhou Children's Hospital were enrolled study. Serum IFN-γ IL-10 levels measured by enzyme linked-immunosorbent assay. Polymorphisms at position +874 +2109, -1082 analyzed...
In order to examine the role of peripheral blood lymphocyte subsets on diagnosis, treatment and prognosis hemophagocytic lymphohistiocytosis (HLH), 30 affected children during acute period disease healthy within same age range were selected test their using flow cytometry compare these subsets. At time, 20 with complete remission from HLH compared those 10 cases who succumbed disease. The proportion CD3+ CD8+ T cells increased in period. Additionally, CD4+ CD3-CDl6+CD56+ natural killer (NK)...
Abstract The ubiquitin‐proteasome system is the primary cellular pathway for protein degradation, mediating 80% of intracellular degradation. Because widespread presence ubiquitin‐modified substrates, ubiquitination can regulate a variety activities including cell proliferation, apoptosis, autophagy, endocytosis, DNA damage repair, and immune responses. With continuous generation genomics data in recent years it has become particularly important to analyze these effectively reasonably....
Survival after acute paediatric (0-14 years), adolescent (15-19 years) and young adult (20-39 leukaemia has improved substantially over the last five decades, particularly for lymphoblastic (ALL) promyelocytic leukaemia. This progress represents one of most successful achievements in history medicine been attributed to development effective chemotherapy regimens, improvement supportive care, better risk stratification, use targeted therapies, advances haematopoietic stem cell...
The cell cycle is a dynamic process with multiple phases regulating growth. proper regulation essential for avoiding errors and activation of death. Tumour suppressor proteins, including tuberin, are crucial in coordinating adequate growth properly timed division. So, the present review article focused on latest aspects tuberin carcinogenesis. PubMed was main database used collection data relating to especially context cancer. Most recent studies revealed that mutation, truncation,...