A5043470517- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
Athinoula A. Martinos Center for Biomedical Imaging
2022-2024
Harvard University
2022-2024
Massachusetts General Hospital
2022-2024
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In central nervous system (CNS), COX-2 implicated neurodegenerative psychiatric disorders as potential therapeutic target biomarker. However, clinical studies with have yielded inconsistent results, partly due to limited mechanistic understanding of how activity relates CNS pathology. Therefore, developing positron emission tomography (PET) radiotracers for human...
Voltage-gated sodium channels (Navs) play a crucial electrical signaling role in neurons. Nav-isoforms present peripheral sensory neurons and dorsal root ganglia of the spinal cord are critically involved pain perception transmission. While these isoforms, particularly Nav1.7, implicated neuropathic disorders, changes functional state expression levels have not been extensively studied vivo. Radiocaine, fluorine-18 radiotracer based on local anesthetic lidocaine, non-selective Nav blocker,...