As the therapeutic agent for antiviral applications, clinical use of oseltamivir is limited with appearance drug-resistant viruses. It important to explore novel anti-influenza drugs. The activity silver nanoparticles (AgNPs) has attracted increasing attention in recent years and was a possibility be employed as biomedical intervention. Herein, we describe synthesis surface decoration AgNPs by using (OTV) properties inhibition drug resistance. Compared oseltamivir, oseltamivir-modified...

Galactose-modified selenium nanoparticles (GA-SeNPs) loading with doxorubicin (DOX) for hepatocellular carcinoma (HCC) therapy was investigated in this paper. Selenium (SeNPs) were modified galactose as tumor targeting moiety to fabricate tumor-targeted delivery carrier GA-SeNPs, then loaded onto the surface of GA-SeNPs improving antitumor efficacy DOX HCC therapy. Chemical structure characterization GA-Se@DOX showed that successfully prepare functionalized drug system GA-Se@DOX. exhibited...

Ribavirin (RBV) is a broad-spectrum antiviral drug. Selenium nanoparticles (SeNPs) attract much attention in the biomedical field and are used as carriers of drugs current research studies. In this study, SeNPs were decorated by RBV, novel nanoparticle system was well characterized. Madin-Darby Canine Kidney cells infected with H1N1 influenza virus before treatment SeNPs, loaded RBV (Se@RBV).MTT assay showed that Se@RBV protect during infection vitro. depressed titer culture supernatant....

Small interfering RNA (siRNA) exhibits great potential as a novel therapeutic option due to its highly sequence-specific ability silence genes. However, efficient and safe delivery carriers are required for developing paradigms. Thus, the successful development of platforms siRNA is crucial issue siRNA-based drugs in cancer treatments. In this study, biocompatible selenium nanoparticles (SeNPs) were loaded with RGDfC peptide fabricate tumor-targeting gene vehicle RGDfC-SeNPs. Subsequently,...

Selenium nanoparticles (SeNPs) loaded with chemotherapeutic drugs provided a novel perspective for cancer therapy.Here, SeNPs were modified cyclic peptide (Arg-Gly-Asp-d-Phe-Cys [RGDfC]) to fabricate tumor-targeting delivery carrier RGDfC-SeNPs and, then, doxorubicin (DOX) was the surface of improving antitumor efficacy DOX in non-small-cell lung carcinoma therapy.The chemical structure characterization RGDfC-Se@DOX showed that successfully prepare functionalized drug system RGDfC-Se@DOX....

As an effective antiviral agent, the clinical application of arbidol is limited by appearance drug-resistant viruses.

Cancer-specific drug delivery represents an attractive approach to preventing undesirable side effects and increasing the accumulation of in tumors. The surface modification selenium nanoparticles (SeNPs) with targeting moieties thus effective strategy for cancer therapy. In this study, SeNPs were modified folic acid (FA), whose receptors overexpressed on cells, including human cervical carcinoma HeLa fabricate tumor-targeting carrier FA-SeNPs nanoparticles. Then, anticancer doxorubicin...

Enterovirus 71 (EV71) which commonly caused the hand-foot-mouth disease (HFMD) has become one of public health challenges worldwide. However, no effective vaccines or drugs for this been developed. Thus, there is an urgent need to find a new strategy treating EV71 infection. Oseltamivir (OT) antiviral agent, but continuous use oseltamivir leads diminished therapeutic effect in clinic. In order improve activity oseltamivir, was loaded onto surfaces selenium nanoparticles (SeNPs) fabricate...

β-Thujaplicin possess a variety of biological activities. The use modified nanoparticles (NPs) to develop novel anti-influenza drugs has increased in recent years. Selenium (SeNPs) with antiviral activity have attracted increasing attention for biomedical intervention. Functionalized SeNPs by β-thujaplicin (Se@TP) surface superior were synthesized this study. Compared virus group (43%), when treated Se@TP (88%), the cell survival rate MDCK cells was 45% higher. could inhibit H1N1 from...

Pulmonary artery smooth muscle cell (PASMC) proliferation contributes to pulmonary vascular remodeling, which ultimately leads arterial hypertension (PAH). Osthole has been previously shown inhibit tumor growth. Our previous experiments demonstrated that osthole could prevent monocrotaline-induced PAH and remodeling in rats its effects might be associated with inhibiting PASMC proliferation. However, the exact mechanism remains unclear. In this study, we observed inhibitory effect of on...

<i>Background:</i> Curcumin, a polyphenolic compound derived from rhizomes of <i>Curcuma</i> spp., has been shown to possess potent anti-fibrotic properties. Here, we investigate the role curcumin in modulating profibrotic action TGF-β human proximal tubule cells (HK-2) and its underlying mechanisms. <i>Methods:</i> HK-2 were stimulated with 5 ng/ml TGF-β<sub>1</sub>. The effects on TGF-β<sub>1</sub>-regulated gene expression Smad...

To obtain a tumor targeting siRNA delivery vehicle for hepatocellular carcinoma treatments, functionalized selenium nanoparticles, Se-PEI-FA, were first prepared by decorating nanoparticles with polycationic polymers, polyethylenimine (PEI), linked folic acid (FA). FA functions as the tumor-targeted molecule to enhance activity, and PEI conjugates siRNA. Se-PEI-FA@siRNA entered HepG2 cells principally via clathrin-mediated endocytosis. Due active effectiveness of FA, has significantly higher...

Abstract Hepatitis B virus (HBV) is a worldwide epidemic pathogen that causes hepatitis B. On‐site screening the HBV infection of critical importance for preventing and diagnosing infection. In this paper, simple, visual, rapid method on‐site detection HBV‐DNA has been developed. This based on betaine‐assisted recombinase polymerase assay followed with naked‐eye via lateral flow (BRPA‐LF). Result show nonspecific amplification prone to occur in (RPA) if was performed serum sample without...


 Purpose: To explore miRNA-875-5p and epidermal growth factor receptor (EGFR) activities in tissues or cells from cervical cancer, their underlying molecular mechanisms.
 Methods: Tissues were obtained cancer patients miR-875-5p expression was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Caski HeLa transfected with mimics inhibitor to assess the effect of miR-875- 5p on cell viability, cycle, migration, invasion using Cell Counting Kit-8...

Objective To investigate the effects of dexmedetomidine on perioperative cellular immune function and micro-metastasis in blood circulation patients undergoing radical operation for colon cancer.Methods Sixty ASA Ⅰ or Ⅱ patients,aged 38-69 yr,weighing 45-67 kg,undergoing cancer,were randomly divided into 2 groups (n =30 each) ∶ group (D group) control (C group).Anesthesia was induced with midazolam,cisatracurium sufentanil,and maintained propofol,remifentanil sevoflurane.After tracheal...

The objectives of this study were to explore the effect Osthole (Ost) on apoptosis in pulmonary artery smooth muscle cells (PASMCs) and investigate potential mechanism effect.Rats injected subcutaneously with monocrotaline (MCT) establish a PAH model, Ost intragastrically administrated from day 1 35. After 35 days administration, mean pressure lung weight index measured. HE TUNEL staining used observe morphology PASMCs. In addition, PASMCs detected by flow cytometry cultured proteins Bax...

Objective To evaluate the role of phosphatidylinositol 3-kinase(PI3K)/serine-threonine kinase(Akt)signaling pathway in propofol-induced invasion human liver cancer cell line HepG2. Methods HepG2 cells were cultured RPMI 1640 medium supplemented with 10% fetal bovine serum a 5% CO2 incubator at 37 ℃.HepG2 logarithmic growth phase divided into 6 groups(n=18 each)using random number table: control group(group C), propofol P), PI3K/Akt signaling agonist IGF-1 IGF), inhibitor LY294002 LY),...

Abstract β-Thujaplicin possess a variety of biological activities. The use modified nanoparticles (NPs) to develop novel anti-influenza drugs has increased in recent years. Selenium (SeNPs) with antiviral attracted increasing attention for biomedical intervention. Functionalized SeNPs by (Se@TP) surface superior were synthesized this study. decoration obviously inhibited H1N1 infection and less toxicity. Se@TP could inhibit from infecting Madin Darby Canine Kidney (MDCK) cells block...

Hepatocellular carcinoma (HCC) is ranked as the second leading cancer-related death in world. Chemotherapy one of most commonly used strategies for HCC patients, while clinical application hampered by its cytotoxicity. To address this dilemma, tumor-targeted nanotechnology has been proposed to balance toxicity and efficacy chemotherapy. Tumor-targeted selenium nanoparticles (HA-SeNPs) were prepared load an anticancer drug doxorubicin (DOX). In delivery system, hyaluronic acid (HA) was a...

Abstract Anti-cancer drugs, either targeted therapies or cytotoxic chemotherapies, have proven to be effective in treating certain cancer patients. However, most cases, tumors recur and become resistant the treatment after a period of time. There are urgent needs understand underlying drug resistance mechanisms, discover targets biomarkers develop new combination tackle this widely occurring clinical problem. Currently main approaches study include analyzing samples developing models vitro....