A5102740148- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Wnt/β-catenin signaling in development and cancer
- Machine Learning in Bioinformatics
- Abdominal Surgery and Complications
- Histone Deacetylase Inhibitors Research
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Insect-Plant Interactions and Control
- Dietary Effects on Health
- Insect and Pesticide Research
- Bioactive Compounds and Antitumor Agents
- Atrial Fibrillation Management and Outcomes
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Galectins and Cancer Biology
- Pancreatic function and diabetes
- Biomarkers in Disease Mechanisms
Sichuan Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Harbin Medical University
2012-2023
Third Affiliated Hospital of Harbin Medical University
2018-2023
Jilin University
2022
First Affiliated Hospital of Harbin Medical University
2014-2016
Tsinghua University
2012
With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in development CRC. We examined expression levels lncRNA CRNDE and miR-181a-5p 64 cases CRC tissues cell lines by qRT-PCR. Gain-of-function loss-of-function assays were performed to examine effect on proliferation chemoresistance cells. Using fluorescence reporter western blot assays, we also explored...
Abstract Colorectal cancer ( CRC ) remains both common and fatal, its successful treatment is greatly limited by the development of stem cell‐like characteristics (stemness) chemoresistance. MiR‐30‐5p has been shown to function as a tumor suppressor targeting Wnt/β‐catenin signaling pathway, but activity in never assessed. We hypothesized that miR‐30‐5p exerts anti‐oncogenic effects regulating USP 22/Wnt/β‐catenin axis. In present study, we demonstrate tissues from patients human cell lines...
Background/Aims: Two major barriers to the successful treatment of colorectal cancer (CRC) are development stem cell-like characteristics (stemness) and chemoresistance. Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme putative CRC marker that has emerged as potential cause both phenomena in CRC. There evidence USP22 acts through Wnt/β-catenin pathway downregulation latter may reduce Methods: In this study, we used tissue specimens from human patients well cell lines...
Molecular hydrogen (H 2 ) has been proven to be an effective agent that can cure multiple organ diseases by reducing oxidative stress. Although the protective effect of on acute pancreatitis ( AP confirmed, its molecular mechanism is still unclear. In this article, we aimed investigate changes in pancreatic cell protein expression associated with H against and attempted uncover underlying process. A proteomic analysis identified 73 differentially expressed proteins generated protein–protein...
This study investigated the anti-oxidative and anti-inflammatory effects of lycopene on severe acute pancreatitis (SAP) in both vivo vitro models. Utilizing a rat model, we found that administration protected against SAP, as indicated by decreased levels serum amylase C-reactive protein. Pathological changes were alleviated pretreatment with lycopene. The tumor necrosis factor-α, interleukin-6, macrophage inflammatory protein-1α, monocyte chemotactic protein-1 reactive oxygen species (ROS)...
Abstract Background Long non-coding RNAs (lncRNAs), acting as competing endogenous RNA (ceRNA) have been reported to regulate the expression of targeted genes by sponging miRNA in colon adenocarcinoma (COAD). Methods However, their potential implications for recurrence free survival prognosis and functional roles remains largely unclear COAD. In this study, we downloaded TCGA dataset (training dataset) GSE39582 (validation COAD patients with prognostic information. Results A total 411...
The present study was conducted to investigate the effect and potential mechanism of hypoxia-inducible factor-1α (HIF-1α) genetic inhibition plus glutamine (Gln) supplementation on necrosis-apoptosis imbalance during acute pancreatitis (AP), with a specific focus regulations intracellular energy metabolism status. Wistar rats AR42J cells were used establish AP models. When indicated, HIF-1α knockdown or without Gln administered. In vivo, local systemic inflammatory injuries assessed by serum...
To compare the early efficacy of external versus internal pancreatic duct drainage after pancreaticoduodenectomy (PD), providing clinical evidence for selecting optimal approach to drainage.The data 395 consecutive patients undergoing PD from 2006 2013 were analyzed retrospectively. All divided into and group. Intraoperative blood loss, surgery duration, postoperative hospitalization mortality rate, PF, other complications compared between two groups. The perioperative relative risk factors...
Ephrin Type-A Receptor 3 (EphA3) and Type-B 6 (EphB6) belong to the ephrin receptor group consisting of largest subset tyrosine kinases (RTKs) are essential for neurogenesis embryogenesis.The current study aimed evaluate their functional roles in transforming colorectal epithelial cells dissect underlying molecular mechanisms.We observed altered EphA3 EphB6 expression tumor tissues as compared normal a tissue microarray study.Enforced promoted IMCE cell proliferation, migration, invasion...
This research discussed the specific mechanism by which PIAS1 affects acute pancreatitis (AP).PIAS1, Foxa2, and FTO expression was assessed in Cerulein-induced AR42J cells mice. Loss- gain-of-function assays Cerulein induction were conducted mice for analysis. The relationship among PIAS1, tested. Cell experiments run triplicate, eight each animal group.Cerulein-induced AP had low Foxa2 high FTO. induced pancreatic injury inflammation oxidative stress tissues, could be reversed or...
In this study, the probiotic yeast
Anticancer peptide (ACP) is a short with less than 50 amino acids that has been discovered in variety of foods. It demonstrated traditional Chinese medicine or food can help treat cancer some cases, which suggests ACP may be one the therapeutic ingredients. Studies on anti-cancer properties Sanghuangporus sanghuang have concentrated polysaccharides, flavonoids, triterpenoids, etc. The function peptides not received much attention. purpose this study to use computer mining techniques search...