A5101675910- Fluid Dynamics Simulations and Interactions
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Advanced Computational Techniques and Applications
- High-Velocity Impact and Material Behavior
- RNA and protein synthesis mechanisms
- Numerical methods in engineering
- Distributed and Parallel Computing Systems
- Machine Learning in Bioinformatics
- Peer-to-Peer Network Technologies
- Genomics and Phylogenetic Studies
- Geotechnical Engineering and Underground Structures
- Protein Structure and Dynamics
- Fluid Dynamics and Heat Transfer
- Metaheuristic Optimization Algorithms Research
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Optics and Image Analysis
- Functional Brain Connectivity Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Topology Optimization in Engineering
- Power Systems and Technologies
- Color Science and Applications
- Circular RNAs in diseases
- Mast cells and histamine
Shanghai Maritime University
2005-2023
ShenZhen People’s Hospital
2022
University of Cincinnati
2013-2021
First Affiliated Hospital of Harbin Medical University
2011-2021
Harbin Medical University
2011-2021
École Nationale des Greffes
2008
China University of Mining and Technology
2002-2005
Xuzhou University of Technology
2000
Sichuan Cancer Hospital
1999
As a prevalent existing post-transcriptional modification of RNA, N6-methyladenosine (m6A) plays crucial role in various biological processes. To better radically reveal its regulatory mechanism and provide new insights for drug design, the accurate identification m6A sites genome-wide is vital. traditional experimental methods are time-consuming cost-prohibitive, it necessary to design more efficient computational method detect sites. In this study, we propose novel cross-species DNN-m6A...
Studies on ballistic penetration to laminates is complicated, but important for design effective protection of structures. Experimental means study expensive and can often be dangerous. Numerical simulation has been an excellent supplement, the computation time-consuming. Main aim this thesis was develop test tool real-time prediction projectile penetrations by training a neural network decision tree regression model. A large number finite element models were developed; residual velocities...
As one of the most prevalent posttranscriptional modifications RNA, N7-methylguanosine (m7G) plays an essential role in regulation gene expression. Accurate identification m7G sites transcriptome is invaluable for better revealing their potential functional mechanisms. Although high-throughput experimental methods can locate precisely, they are overpriced and time-consuming. Hence, it imperative to design efficient computational method that accurately identify sites. In this study, we...
Acute myocardial infarction (AMI) is necrosis caused by the persistent interruption of blood supply, which has high incidence rate and mortality in middle-aged elderly people worldwide. Biomarkers play an important role early diagnosis treatment AMI. Recently, more researches confirmed that circRNA may be a potential diagnostic biomarker therapeutic target for cardiovascular diseases. In this paper, series biological analyses were performed to find new effective biomarkers Firstly,...
Background/Aims: The role of the β3-adrenergic receptor (β3-AR) agonist BRL37344 in atrial fibrillation (AF) structural remodeling and underlying mechanisms as a therapeutic target were investigated. Methods: Four groups dogs evaluated: sham, pacing, β3-AR (β3-AGO), antagonist L748337 (β3-ANT) groups. Dogs β3-AGO β3-ANT subjected to rapid pacing for four weeks. Atrial structure function, AF inducibility duration, myocyte apoptosis interstitial fibrosis assessed. superoxide anions evaluated...
Accumulating evidence suggests that the adrenergic receptors (ARs) play an important role in cardiac diseases. The expression of β3-AR has been recently demonstrated atria, however, its atrial structural remodeling fibrillation (AF) is unclear. Therefore, present study was designed to investigate AF and clarify possible mechanisms. Twenty-eight dogs were randomly divided into sham, pacing, agonist (BRL37344) antagonist (L748337) groups. induced by rapid pacing at 600 beats per minute for 3...
The tremendous growth of public interest in Peer-to-Peer (P2P) networks recent years has initiated a lot research work on how to design efficient overlays for P2P systems. Among them are some that support range queries, but their basic topologies might be different with diverse options, such as ring, cluster, binary tree and doubly-linked lists, etc. In this paper, we present self-adaptive overlay dynamic cluster structure supports queries. cluster-based topologies, challenge issue is choose...
Considering the characteristics of production dispatching container terminals, a multi-agent-based information integration system for an automated terminal is presented in this paper. First, basic architecture and function corresponding agent are described. Then, cooperation coordination working mechanism integrated shown. Also, design embedded with communication between agents technology discussed. Finally, partial implemented prototype given. The experiment results support validity system.
Background and Objective. Atrial fibrillation (AF) is linked to high morbidity death rates throughout the world due limited therapeutic options thus presents a major challenge developed developing countries. In this study, we aim investigate influence of sacubitril/valsartan (sac/val) treatment on calmodulin-dependent protein kinase II (CaMKII)/Cav1.2 expression in AF models. Methods. Overall, 18 rabbits were randomly divided into control, pacing (600 beats/min), pacing+sac/val groups. The...
Background: Nitration is an important Post-Translational Modification (PTM) occurring on the tyrosine residues of proteins. The occurrence protein nitration under disease conditions inevitable and represents a shift from signal transducing physiological actions - NO to oxidative potentially pathogenic pathways. Abnormal modification can lead serious human diseases, including neurodegenerative acute respiratory distress, organ transplant rejection lung cancer. Objective: It necessary identify...