A5020854626- Parathyroid Disorders and Treatments
- Education and Work Dynamics
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Higher Education and Teaching Methods
- Advanced Neuroimaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Polymer Surface Interaction Studies
- Sport and Mega-Event Impacts
- Biomarkers in Disease Mechanisms
- Synthesis and Catalytic Reactions
- Advanced Graph Neural Networks
- Hydraulic Fracturing and Reservoir Analysis
- Thyroid and Parathyroid Surgery
- Neurological and metabolic disorders
- Bone Tissue Engineering Materials
- Topic Modeling
- BRCA gene mutations in cancer
- Advanced Text Analysis Techniques
- Radical Photochemical Reactions
- Traumatic Brain Injury Research
- Methane Hydrates and Related Phenomena
- Metamaterials and Metasurfaces Applications
Northwest Normal University
2022-2024
Kennedy Krieger Institute
2023-2024
Peking University
2010-2024
Tianjin Normal University
2024
Beijing Jishuitan Hospital
2010-2024
Capital Medical University
2024
University College London
2024
Johns Hopkins University
2023
Fujian Medical University
2022
China University of Geosciences (Beijing)
2022
Purpose To estimate the exchange rate of creatine (Cr) CEST and to evaluate pH sensitivity guanidinium (Guan) in mouse brain. Methods Polynomial Lorentzian line‐shape fitting (PLOF) were implemented extract amine, amide, Guan signals from brain Z‐spectrum at 11.7T. Wild‐type (WT) knockout mice with guanidinoacetate N‐methyltransferase deficiency (GAMT −/− ) that have low Cr phosphocreatine (PCr) concentrations used CrCEST signal. quantify rate, a two‐step Bloch‐McConnell (BM) was fit...
A visible-light-induced tandem reaction involving quinoxalin-2(1
The accumulation of mutant huntingtin protein aggregates in neurons is a pathological hallmark Huntington's disease (HD). glymphatic system, brain-wide perivascular network, facilitates the exchange interstitial fluid (ISF) and cerebrospinal (CSF), supporting solute clearance brain wastes. In this study, we employed dynamic glucose-enhanced (DGE) MRI to measure D-glucose from CSF as tool predict function mouse model HD. We found significantly diminished efficiency HD mice prior phenotypic...
The staging system for patients with anaplastic thyroid cancer (ATC) was updated in the 8th edition of American Joint Committee on Cancer Staging Manual. A cut-off age 55 years stipulated as a prognostic factor differentiated cancer; however, not considered ATC patients. To this end, study investigated relationship between at diagnosis and prognosis patients.The clinical information acquired from Surveillance, Epidemiology, End Results Program public database. Youden's index X-tile analyses...
ABSTRACT Huntington’s disease (HD) is a neurodegenerative disorder that presents with progressive motor, mental, and cognitive impairment leading to early disability mortality. The accumulation of mutant huntingtin protein aggregates in neurons pathological hallmark HD. glymphatic system, brain-wide perivascular network, facilitates the exchange interstitial fluid (ISF) cerebrospinal (CSF), supporting solute clearance including abnormal proteins from mammalian brains. In this study, we...
<abstract><p>Disease prediction by using a variety of healthcare data to assist doctors in disease diagnosis is becoming more and important research topic recently. This paper proposes model that fuses multiple types encoded representations Chinese electronic health records (EHRs). The framework utilizes multi-head self-attention mechanism, which combines textual numerical features enhance text representations. BiLSTM-CRF TextCNN models are used, respectively, extract entities...
Natural gas hydrates are a strategic energy resource in China. The China Geological Survey has discovered segregated hydrate mass formations under the seepage mechanism South Sea through exploration, and occur nodular, massive, vein silty clay sediment. Previous work focused on analysis of sediment mechanical properties with respect to uniform distribution natural pore spaces, but hydrate-bearing sediments containing masses not well understood. Spherical used characterize nodular hydrates,...
Herein, we describe the construction of indole-fused seven-membered N- and O-heterocycles from indolyl α-diazocarbonyls via photoredox-catalyzed intramolecular cyclization. The photoredox process features operational simplicity, mild conditions, as low 0.1 mol % catalyst loading. tricyclic heterocycles are obtained in yields 24 to 67% with excellent regioselectivity. practicality this protocol is further demonstrated by gram-scale reactions carried out both batch continuous flow.
ABSTRACT The degree and scope of constraints imposed by International Organizations (IOs) on States are increasing, identifying the factors affecting IOs’ stances is helpful to enhance state's discourse power influence in international community. First, coding records Regular Press Conferences Speaking Office Chinese Ministry Foreign Affairs during period 20182022, we obtained a dataset China-related events. Second, constructed political relation, economic humanistic relation indicators...
Patients with primary hyperparathyroidism (PHPT) are at risk for severe hypocalcemia (SH) following parathyroidectomy (PTX), but limited data exist on the predictors of SH. We aimed to identify factors early postoperative SH after PTX in patients PHPT and evaluate predictive value clinical parameters.
Shortwave-infrared(SWIR) spectral information,ranging from 1 {\mu}m to 2.5{\mu}m, breaks the limitations of traditional color cameras in acquiring scene information and has been used many fields. However, conventional SWIR hyperspectral imaging systems face challenges due their bulky setups low acquisition speed. In this work, we introduce a snapshot system based on metasurface filter corresponding selection method achieve lowest correlation coefficient among these filters.This systemhas...
Guanidinium CEST (GuanCEST) and amideCEST are highly sensitive to pH change, while their correlations with opposite. Thus taking (unitless) difference of GuanCEST provides a reliable indicator for pH. Polynomial Lorentzian line-shape fitting (PLOF) method helps extract the two signals precisely, shows significant increase (p=0.008, n=10) in Alzheimer’s disease (AD) mouse brain compared that wild type at 3T. Our results light up novel promising detect onset AD noninvasively, bringing recent...
We aim to use three different approaches estimate the exchange rate of creatine (Cr) CEST, i.e., pure CrCEST line-shape, B1-dependent CrCEST, and pH response with B1 values. The signal extracted using wild type GAMT-/- mice low Cr PCr concentrations; in brain cells altered by hypercapnia demonstrate sensitivity GuanCEST; a two-step Bloch-McConnell fitting implemented quantify rates. vivo was found slow (~260-350 s-1). is major contribution opposite pH-dependence GuanCEST under B1.
Motivation: While myelination is known to progress rapidly in the infant brain, specific progression finer cortical regions and white matter (WM) tracts remain elusive. The precise effects of environmental impacts on brain maturation require further investigation. Goal(s): Our goal was delineate differential trajectories across WM during infancy explore their associations with factors. Approach: T1-weighted T2-weighted images were used map myelin content analyzed generalized additive...
With the rapid development of national fitness, country has clearly promoted “Internet+fitness”, and many professional sports technicians have participated in live fitness activities become web celebrities. Sports weblebrities are a powerful guarantee for improving level general public, health media led by them promote audience’s willingness to exercise, resulting better communication effect. From perspective interactive ritual chain, this paper investigates why broadcasts can exercise...
The widespread availability of multi-detector spiral CT and its post processing techniques,and MRI,provide us with important tools to carry out anatomical studies on pancreaticobiliary maljunction (PBM).Determining the relationship between PBM biliary diseases contributes not only a better understanding pathogenesis pathological process diseases,but it also provides evidence for prophylactic treatment.The present study reviewed definition,classification,pathological anatomy PBM,relationship...
Preoperative diagnosis of biliary obstruction mainly depends on imaging examination.Percutaneous transhepatic cholangiography (PTC) is a common method in detecting obstruction.PTC combined with computed tomography (CT) could enhance the diagnostic rate.From April 2009 to 2011,8 patients were admitted Shenzhen Hospital Peking University.Contrast solution (30 ml iodine at concentration 1.5％ -2.0％)was injected through PTC tube,and then CT scan was performed.An iohexol contrast 300 mgl/ml dosage...
Objective To summarize the experience on diagnosis and treatment of primary hyperparathyroidism(PHPT).Methods Clinical data 91 PHPT patients treated in Beijing Jishuitan Hospital from November 1992 to December 2008 were analyzed retrospectively.Results Among cases,88 diagnosed as parathyroid adenoma(96.7%),3 carcinoma (3.3%).Serum calcium PTH levels increased all cases.Main clinical manifestations osteodynia kidney stones.The accuracy rate preoperative B-ultrasound.CT ECT~(99m)Tc-MIBI...