Songnan Wen

ORCID: 0000-0002-6256-3189
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About
Contact & Profiles
Research Areas
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Arrhythmias and Treatments
  • Cardiac electrophysiology and arrhythmias
  • Cardiac pacing and defibrillation studies
  • Cardiac Imaging and Diagnostics
  • Cardiomyopathy and Myosin Studies
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Cardiac tumors and thrombi
  • Venous Thromboembolism Diagnosis and Management
  • Galectins and Cancer Biology
  • Congenital Heart Disease Studies
  • Cardiovascular Effects of Exercise
  • Ultrasound in Clinical Applications
  • Cardiovascular Disease and Adiposity
  • Peptidase Inhibition and Analysis
  • Aortic Thrombus and Embolism
  • Cerebrovascular and Carotid Artery Diseases
  • Pulmonary Hypertension Research and Treatments
  • Cardiac Fibrosis and Remodeling
  • ECG Monitoring and Analysis
  • Viral Infections and Immunology Research
  • Cardiovascular and Diving-Related Complications
  • Macrophage Migration Inhibitory Factor
  • Bone and Dental Protein Studies

Mayo Clinic
2019-2024

Beijing Anzhen Hospital
2014-2024

Capital Medical University
2014-2024

Mayo Clinic in Arizona
2022-2024

Mayo Clinic Hospital
2023-2024

University of Southern California
2024

Mayo Clinic in Florida
2021-2024

WinnMed
2021-2024

Banner - University Medical Center Phoenix
2024

Southerners on New Ground
2015

This study sought to explore the relationship between plasma galectin-3 (Gal-3) and persistent atrial fibrillation (PsAF), investigate whether Gal-3 predicts clinical outcomes in patients with PsAF undergoing catheter ablation. Fifty consecutive without coexisting structural heart disease first-time ablation 46 healthy controls were included. Blood samples collected on admission for analysis of Gal-3. Pre-ablation laboratory data also recorded. Persistent fibrillations followed after AF...

10.1093/europace/euv045 article EN EP Europace 2015-04-28

Abstract Background In the USA, prolonged effective survival of cancer population has brought significant attention to rising risk cardiometabolic morbidity and mortality in this population. This heightened underscores urgent need for research into pharmacological interventions survivors. Notably, metformin, a well-known metabolic regulator with pleiotropic effects, shown protective effects against disorders diabetic individuals. Despite these promising indications, evidence supporting its...

10.1186/s12916-024-03484-y article EN cc-by BMC Medicine 2024-06-26

The arrhythmogenic mechanisms of atrial fibrillation (AF) that are induced by acute inflammation, such as postoperative AF, not well understood. We investigated the effects tumour necrosis factor-α (TNF-α) mimic inflammation on Ca2+ handling in isolated myocytes and its underlying mechanisms. Cytosol mitochondrial reactive oxygen species (ROS) production were studied freshly wild-type mice exposed to TNF-α (0.05 ng/mL) for 2 h Ionoptix confocal microscopy. decreased amplitudes prolonged...

10.1093/europace/eux271 article EN EP Europace 2017-10-17

Pericardiocentesis is usually completed under fluoroscopy. The electroanatomic mapping (EAM) system allows visualizing puncture needle tip (NT) while displaying the electrogram recorded from NT, making it possible to obtain epicardial access (EA) independent of This study was designed establish and validate a technique by which EA obtained guidance three-dimensional (3D) EAM combined with NT electrogram.

10.1093/europace/euae089 article EN cc-by-nc EP Europace 2024-04-08

Abstract Background Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation AF has not been well determined. This study aims to explore the long‐term outcomes patients with after ablation. Methods Forty‐two 11,752 who underwent from 2011 2020 were enrolled as group. After propensity score matching in a 1:4 ratio, 168 without non‐LBBB Late recurrence composite endpoint stroke, all‐cause mortality, cardiovascular...

10.1111/pace.14954 article EN Pacing and Clinical Electrophysiology 2024-02-26

Catheter ablation is underutilized in atrial septal defect (ASD) patients who have undergone implantation of an occluder (ASO). This study evaluates the feasibility and safety catheter fibrillation (AF) this subset patients. Sixteen (age 56 ± 12 years, 10 men) with drug-refractory AF (10 paroxysmal 6 persistent) previously implanted ASO were enrolled. Balloon dilatation closure device was performed if native septum passage could not be achieved. For AF, strategy circumferential pulmonary...

10.1093/europace/eux282 article EN EP Europace 2017-11-02

Background Previous studies have provided conflicting results as to whether women are at higher risk than men for thromboembolism in the setting of atrial fibrillation ( AF ). We investigated with were ischemic stroke China-AF (China Atrial Fibrillation Registry) Study. Methods and Results A total 19 515 patients prospectively enrolled between August 2011 December 2016 China- After exclusion receiving anticoagulation or ablation therapy, 6239 (2574 women) from least 6 months follow-up used...

10.1161/jaha.118.009391 article EN cc-by-nc-nd Journal of the American Heart Association 2018-09-26

Catheter ablation of perimitral atrial tachycardia (PMAT) is challenging. Epicardial conduction the Marshall bundle (MB) across mitral isthmus (MI) remains an important cause recurrent tachycardia. The role ethanol infusion into vein (EI-VOM) for PMAT has not been fully elucidated.The study enrolled 28 consecutive patients with after fibrillation (AF) ablation. Conventional (group 1, n = 15) and MB-related 2, 13) were diagnosed by detailed activation mapping entrainment mapping. VOM...

10.1111/pace.14052 article EN Pacing and Clinical Electrophysiology 2020-08-28

Current knowledge on the dynamic changes of corrected QT (QTc) before, during, and after an atrial fibrillation (AF) episode is limited. It remains controversial which presently available formulas performs best in calculating QTc during AF. This study was designed to explore whether AF attack would affect determine performance 6 correcting A total 101 patients with Holter-documented paroxysmal were enrolled. interval measured heart rate (HR) by using Bazett, Fridericia, Framingham, Hodges,...

10.1016/j.amjcard.2021.12.016 article EN cc-by The American Journal of Cardiology 2022-01-20

Abstract Introduction To assess the long‐term outcome of catheter ablation in patients with hypertrophic cardiomyopathy (HCM), especially apical HCM (ApHCM). Methods and results From 9,249 AF cases, 97 (28 ApHCM 69 non‐ApHCM) were enrolled. Another matched by age, type, duration, left atrial diameter selected as control group. After a mean follow‐up (44.3 ± 29.6) months, success rate after single procedure was 42.9% (P = 0.725), 36.2% non‐ApHCM 0.136) versus 50.5% multiple procedures, both...

10.1111/jce.13645 article EN Journal of Cardiovascular Electrophysiology 2018-06-02

Left atrial (LA) function can be impaired by the fibrillation (AF) ablation and might associated with risk of recurrence. We sought to determine whether post-procedural changes in LA impact recurrence following AF ablation.We retrospectively reviewed patients who underwent between 2009 2011 transthoracic echocardiography before ablation, 1-day 3-month after ablation. Peak left contraction strain (PACS) emptying fraction (LAEF) were evaluated during sinus rhythm compared across three time...

10.1186/s12947-021-00250-5 article EN cc-by Cardiovascular Ultrasound 2021-06-11

Background:In hypertrophic cardiomyopathy (HCM) patients complicated with atrial fibrillation (AF), catheter ablation has been recommended as a treatment option. Meanwhile, prolongation of QTc interval linked to an increased AF incidence in the general population and poor outcomes HCM patients. However, whether predicts arrhythmia recurrence after remains unknown.Methods Results:Thirty-nine undergoing primary were enrolled. The strategy included bilateral pulmonary vein isolation (PVI) for...

10.1253/circj.cj-14-1290 article EN Circulation Journal 2015-01-01

Novel coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and precise fatality data by age group is needed urgently. This study to delineate the clinical characteristics outcome of COVID-19 patients aged ≥75 years identify risk factors in-hospital death.A total 141 consecutive who were admitted hospital between 12th 19th February 2020. In-hospital death, laboratory findings on admission obtained from medical records. The final follow-up observation was 31st March 2020.The...

10.1186/s12877-020-01921-0 article EN cc-by BMC Geriatrics 2020-11-30

Background: Early diagnosis of significant valvular heart disease (VHD) enables appropriate implementation the best therapeutic strategy and follow-up. Cardiac auscultation remains suboptimal in early detection VHD. The aim this study was to evaluate utility point-of-care ultrasound (POCUS) for VHD its severity. Methods: All consecutive patients with who did not have a standard echocardiogram prior first outpatient cardiology consultation underwent history physical examination followed by...

10.3390/jcm12206474 article EN Journal of Clinical Medicine 2023-10-11

Cardiac tamponade is a rare but life-threatening complication during atrial fibrillation (AF) catheter ablation. Contact force (CF)–sensing catheters improve ablation effectiveness. However, the impact of application CF-sensing on occurrence cardiac remains unclear. The aim this study to evaluate "real-world" AF in an experienced medical center. This was retrospective consecutive de novo procedures at Beijing Anzhen Hospital between 2013 and 2016. procedure divided into CF group non-CF...

10.1007/s10840-019-00516-z article EN cc-by Journal of Interventional Cardiac Electrophysiology 2019-02-02

Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 rs4652, plasma Gal-3 level, MF major adverse events (MAEs) were obtained. Results: There was no significant difference MAEs when categorizing patients by SNPs rs4652. circulating related degree (p < 0.001). Plasma level can predict an increased risk 0.001, p = 0.023,...

10.2217/bmm-2020-0269 article EN cc-by-nc-nd Biomarkers in Medicine 2020-08-01
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