A5057012907- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Psychosomatic Disorders and Their Treatments
- Medical Imaging Techniques and Applications
- Hormonal Regulation and Hypertension
- Health, psychology, and well-being
- Mental Health Treatment and Access
- Psychiatric care and mental health services
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Sympathectomy and Hyperhidrosis Treatments
- Cerebrospinal fluid and hydrocephalus
- Cerebral Venous Sinus Thrombosis
Philipps University of Marburg
2015-2023
University of Zurich
2020-2023
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2022
Universitäre Psychiatrische Dienste Bern
2021
Swiss Paediatric Oncology Group
2021
Universitätsklinikum Gießen und Marburg
2014-2016
University of Münster
2008-2015
University Hospital Münster
2014
Klinik und Poliklinik für Neurologie
2012
<h3>Importance</h3> Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, biomarkers that accurately predict a response to ECT remain unidentified. <h3>Objective</h3> To investigate whether certain factors identified by structural magnetic resonance imaging (MRI) techniques are able response. <h3>Design, Setting, and Participants</h3> In this nonrandomized prospective study, gray matter structure was assessed twice at approximately 6 weeks...
Background Electroconvulsive therapy (ECT) is one of the most effective treatments for severe depression. However, little known regarding brain functional processes mediating ECT effects. Method In a non-randomized prospective study, magnetic resonance imaging data during automatic processing subliminally presented emotional faces were obtained twice, about 6 weeks apart, in patients with major depressive disorder (MDD) before and after treatment (ECT, n = 24). Additionally, control sample...
BackgroundIntermittent theta-burst stimulation (iTBS), a novel repetitive transcranial magnetic (rTMS) technique, appears to have antidepressant effects when applied over left dorsolateral prefrontal cortex (DLPFC). However, its underlying neurobiological mechanisms are unclear. Proton resonance spectroscopy (1H-MRS) provides in vivo measurements of cerebral metabolites altered major depressive disorder (MDD) like N-acetyl-aspartate (NAA) and choline-containing compounds (Cho). We used MRS...
There is strong evidence for a genetic contribution to the pathogenesis of depression, with functional catechol-O-methyltransferase (COMT) val158met polymorphism having been suggested as potential susceptibility factor. In present study, effect COMT on response electroconvulsive therapy (ECT) was analyzed in sample 104 Caucasian patients (f = 71, m 33) pharmacologically treatment-resistant Major Depression. The higher active 158val allele found be associated (1) pre-ECT severity depression...
Dysfunction of dopamine D₃ receptors, particularly in the mesocorticolimbic system, has been linked to pathogenesis major depression. Preclinical data show enhanced receptor binding striatum upon antidepressant medication and electroconvulsive therapy (ECT). Thus, potential impact gene (DRD3) variation on ECT outcome treatment-resistant depression was evaluated by applying a combined molecular imaging genetic approach. Altogether, 10 representative variants covering 95.4% DRD3 were...
Mineralocorticoid-receptor (MR) dysfunction as expressed by low systolic blood pressure and a high salivary aldosterone/cortisol ratio predicts less favorable antidepressant treatment outcome. Inhibition of peripheral 11-beta-hydroxysteroid-dehydrogenase type 2 (11betaHSD2) reverses these markers. We therefore tested the hypothesis that 11betaHSD2 inhibitor glycyrrhizin affects outcome via this mechanism. administered Glycyrrhiza glabra (GG) extract containing 7–8 % at dose × 700 mg daily...
Brain morphology and its relation to endocrine parameters were examined, in order determine the link of these treatment outcome psychopharmacological depressed patients.We examined potentially predictive value Magnetic Resonance Imaging (MRI) related mineralocorticoid receptor (MR) function on depression. 16 inpatients with a major depressive episode (MDE) studied at baseline 14 them approximately six weeks later. Physiological biomarkers 3-T-structural MRI based volume measures, using...
According to the United Nations, access medical care is a fundamental human right. However, there widespread stigmatization of severe mental illnesses and this appears seriously hamper quality healthcare in people with psychiatric co-morbidity. Thus, interventions that help reduce stigma among providers are urgently needed.The objective current study was investigate effects clerkship on stigmatizing attitudes toward disorders held by students.Between 2018 2019, total 256 third- fourth-year...
Background. Treatment of bipolar depression with antidepressants has often been reported to be associated a certain risk rapid cycling (RC). Also, non-pharmacological treatment approaches such as sleep deprivation or light therapy can induce affective shifts. Moreover, during electroconvulsive (ECT), which is considered powerful antidepressant treatment, manic switches and episodes occur. Methods. Here we report the case 66-year-old female patient depression, who underwent because...
PET of β-Amyloid plaques (Aβ) using [18F]florbetaben ([18F]FBB) and [18F]fluorodeoxyglucose ([18F]FDG) increasingly aid clinicians in early diagnosis dementia, including Alzheimer’s disease (AD), frontotemporal disease, dementia with Lewy bodies, vascular dementia. The aim this retrospective analysis was to evaluate clinical relevance [18F]FBB, [18F]FDG complimentary CSF measurements patients suspected In study, 40 clinically or history underwent (1) measurement Aβ peptides, total tau, p-tau...
Treating very-late-onset (>60 years) schizophrenia-like psychosis (VLOSLP) is challenging. Age-related factors in elderly individuals (e.g., metabolism, medication side effects, drug-interaction, somatic morbidity) may adversely affect treatment. Novel therapeutic approaches are needed to ensure the favorable outcome geriatric patients. Previously, theta-burst stimulation (TBS), a novel form of repetitive transcranial magnetic stimulation, was reported being beneficial treatment for...
In the present work, we report two cases of monozygotic twins who developed prolonged apnea during electroconvulsive therapy (ECT) as a complication anesthesia. both cases, action succinylcholine caused by butyrylcholinesterase (BCHE) deficiency was confirmed means dibucaine number test. genetic analysis using polymerase chain reaction revealed haplotype combined A and K variant mutations BCHE gene, in heterozygous form. These data show potential risk anesthesia ECT, particular underline...