A5101699323- Mycotoxins in Agriculture and Food
- Plant Disease Resistance and Genetics
- Selenium in Biological Systems
- Soil Carbon and Nitrogen Dynamics
- Trace Elements in Health
- Parasitic Infections and Diagnostics
- Expert finding and Q&A systems
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Cardiac Ischemia and Reperfusion
- Fungal and yeast genetics research
- Allelopathy and phytotoxic interactions
- Insect and Pesticide Research
- Soil Geostatistics and Mapping
- Wheat and Barley Genetics and Pathology
- Insect Resistance and Genetics
- Plant Virus Research Studies
- Entomopathogenic Microorganisms in Pest Control
- Congenital Anomalies and Fetal Surgery
- Phytochemistry and Bioactivity Studies
- Essential Oils and Antimicrobial Activity
- Research in Cotton Cultivation
- Advancements in Transdermal Drug Delivery
- Agriculture, Plant Science, Crop Management
- Peptidase Inhibition and Analysis
Beihang University
2024-2025
Center for Life Sciences
2025
Tsinghua University
2025
Yunnan University
2024
Shandong University of Traditional Chinese Medicine
2022
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2022
Zhejiang University
2009-2022
Institute of Geographic Sciences and Natural Resources Research
2011-2022
Chinese Academy of Sciences
2011-2022
Nanjing Medical University
2022
Hu sheep, a famous breed in the Taihu Basin, has advantages of non-seasonal estrus, multiple fetuses, coarse feeding tolerance, and suitability for house feeding. Runs homozygosity (ROHs) were found to be an effective tool detect animal population structure economic traits. The detection ROHs is beneficial reducing incidence inbreeding as well identifying harmful variants genome. However, there lack systemic reports on ruminants previous studies ROHs. Here, we sequenced 108 detected sheep...
Ochratoxin A (OTA) and Zearalenone (ZEA) are widespread mycotoxins that contaminate foodstuffs simultaneously, but sufficient data regarding their mixed toxicities lacking. This study aims to analyze the style of combined effects OTA ZEA on cells target organs. For this purpose, cytotoxicity was determined in HepG2 KK-1 treated with single forms ZEA. Furthermore, we have analyzed using two mathematical models based concepts concentration addition (CA) independent (IA). By analyzing nonlinear...
Abstract Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase (MAPKKK, MAP3K) family member that plays an important role oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 HEK293 cells employed iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism OTA-induced Our results showed knockdown...
While large language models (LLMs) are vital for retrieving relevant information from extensive knowledge bases, they always face challenges, including high costs and issues of credibility. Here, we developed a question answering system focused on human health risk using Retrieval-Augmented Generation (RAG). We first proposed framework to generate question–answer pairs, resulting in 300 high-quality pairs across six subfields. Subsequently, created both Naive RAG an Advanced RAG-based...
Substantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads progressive cellular heterogeneities1–3. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual cell is a fundamental goal in developmental biology. Here we develop target chromatin indexing tagmentation (TACIT), method enabled genome-coverage profiling seven across mouse embryos. We integrated these...
Gypenoside (GP) is the major effective component of Gynostemma pentaphyllum and has been shown to encompass a variety pharmacological activities. In this study, we investigated whether GP able protect cardiomyocytes against injury myocardial ischemia-reperfusion (I/R) by using in vitro oxygen-glucose deprivation-reoxygenation (OGD/R) H9c2 cell model vivo I/R rat model. We found that pre-treatment alleviated impairments on cardiac structure function injured rats. Moreover, with significantly...
Abstract Zearalenone (ZEA) mainly injures the reproductive system of mammals. In present study, we aimed to explore mechanism by which zinc inhibits ZEA-induced damage in KK-1 cells for first time. The results shown that both sulfate and gluconate addition increased intracellular concentration influenced expression transporters (Slc30a1 Slc39a1) a time-dependent manner. Co-incubation with ZEA significantly reduced reactive oxygen species malondialdehyde elevation promoting transcription Mtf1...
Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus. Patients with LN mostly die sclerosing glomerulonephritis and renal failure. The inhibition glomerular mesangial matrix deposition an efficient method to restrict progress injury. By recognizing binding extracellular intracellular ligands, Toll-like receptor 2 (TLR2) contributes pathogenesis immune diseases. However, relationship between TLR2 still unknown. Our previous studies confirmed that high-mobility...
Abstract TRIM27 (tripartite motif‐containing 27) is a member of the TRIM motif) protein family and participates in variety biological processes. Some research has reported that was highly expressed certain kinds carcinoma cells tissues played an important role proliferation cells. However, whether takes part progression lupus nephritis (LN) especially remains unclear. Our study revealed overexpression observed kidneys patients with LN, mice mesangial exposed to LN plasma which correlated ECM...
Available abundant genomic data allows us to study the evolution of yeast genome at a fine scale. In this study, we examined adaptive coding and promoter regions in three Saccharomyces cerevisiae strains. First, using maximum-likelihood approach, identified 76 positively selected genes (PSG) whose likely have undergone positive selection recent past. These show significant bias terms biological function they over-representation charged amino acids sites. Next, on transcription-start sites...
Lung cancer is the most common in world and main cause of cancer-related death. Revealing potential mechanism malignant characteristics lung urgent for treating this disease effectively. Zinc finger protein 671 (ZNF671) a member largest transcription factor family human genome. The role ZNF671 non-small-cell (NSCLC) remains unknown. purpose study was to investigate function NSCLC.ZNF671 expression NSCLC cells tissues were detected by Real-Time PCR, Western blot TCGA databases. Then, we...
Background IgA vasculitis Nephritis (IgAVN) is a kidney-damaging disease that occurs during the course of (IgAV) and most serious complication IgAV. However, there lack reports bibliometric analysis IgAVN in children. The purpose this study to conduct children from 2000 2022, explore current status cutting-edge trends field children, establish new directions for subsequent research. Methods Screening literature Web Science Core Collection (WoSCC) 2022. Visual their annual publications,...
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin human plasma.
Structural cuticular proteins (CPs) are the primary components of insect cuticle, linings salivary gland, foregut, hindgut and tracheae, midgut peritrophic membrane. Variation CPs in cuticle can cause penetration resistance to insecticides. Moreover, depletion specific CP by RNA interference may be a suitable way for development potential pest control traits. Leptinotarsa decemlineata (Say) poorly characterized at present, therefore, we mined genome transcriptome data better annotate...