A5085611922- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Tracheal and airway disorders
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Head and Neck Anomalies
- Biological Research and Disease Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Head and Neck Cancer Studies
- Glutathione Transferases and Polymorphisms
- Nosocomial Infections in ICU
- Infections and bacterial resistance
- Genomics, phytochemicals, and oxidative stress
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- IL-33, ST2, and ILC Pathways
Hunan Provincial People's Hospital
2010-2024
Hunan Normal University
2018-2024
Weatherford College
2021
Tianjin Medical University
2015
Tianjin First Center Hospital
2015
University of South Florida
2006
Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance allele loss 16, we performed restriction fragment length polymorphism analysis 70 surgically resected tumors by using 15 polymorphic DNA markers for 16. was detected 36 (52%) 69 informative cases, and region these located between HP locus (16q22.1) CTRB (16q22.3-q23.2). These losses occurred more frequently HCCs poor differentiation, larger...
Smoking is one of the primary causes chronic obstructive pulmonary disease (COPD). Sustained active epithelial‑mesenchymal transition (EMT) in COPD may explain core pathophysiology airway fibrosis and why lung cancer so common among smokers. Interleukin (IL)‑17A growth/differentiation factor (GDF)15 have been reported to be biomarkers COPD; however, role IL‑17A GDF15 EMT remains unclear. The aim present study was investigate pathogenesis COPD. It demonstrated that are upregulated patients...
The Kinesin Family Member C1 (KIFC1) is highly expressed in a variety of tumors. Since it linked with tumorigenesis and progression, KIFC1 has emerged as promising candidate for targeted chemotherapies. Thus, this study aims to find out the association between lung cancer. original data were assessed from Cancer Genome Atlas Gene Expression Omnibus databases. Compared normal tissues, both mRNA protein levels significantly increased cancer tissues. upregulation was correlated sex,...
The present study aimed to investigate the protective mechanism of ulinastatin against lung injury. Rat models with chronic obstructive pulmonary disease (COPD) were used provide guidance for medical treatment this disease. rats divided into three groups: A control group, a model group and an experimental (each, n=10). With exception all prepared as COPD, using composite molding method smoking intratracheal instillation lipopolysaccharide. in received conventional treatment, while...
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription that regulates antioxidant and anti-inflammatory genes, it plays crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Moreover, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) protective against oxidative stress inflammation both vivo vitro. In previous study, we found 15d-PGJ2 increased expression Nrf2 COPD rat model. This study aims to elucidate relationship between human bronchial epithelial...
The present study was carried out to evolve an effective treatment strategy for chronic obstructive pulmonary disease (COPD). Astaxanthin (AS) is abundantly in red pigments of crustaceans, and has also been proven have considerable biological activities. anti-inflammatory effect AS evaluated lipopolysaccharide (LPS)-exposed RAW264.7 macrophages. It found that markedly inhibited elevation NO pro-inflammatory mediators. Moreover, it downregulated iNOS LPS-stimulated cells, suppressed the...
Background Bronchopneumonia is a disease of the respiratory tract. It leads to other complications and endangers life health. Long non-coding RNA (lncRNA) participates in occurrence development bronchopneumonia. Nuclear paraspeckle assembly transcript 1 (NEAT1) plays key role inflammatory diseases, but function NEAT1 bronchopneumonia remains unclear.Methods RT-qPCR Western blotting were performed determine genes proteins expressions. MTT was applied test cell viability. Cell apoptosis...
Respiratory syncytial virus (RSV) is the primary cause of serious upper and lower respiratory tract infections in infants children worldwide. RSV infection infancy may lead to onset asthma or other health problems later life. An effective vaccine not yet available against infection. Humans respond by mounting an immune response, but antiviral immunity incomplete, thus repeat continue throughout The precise mechanism RSV-induced immunopathology remains unclear. limited knowledge a major...
Abstract Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is less commonly used in nonmalignant diseases. In particular, its application mediastinal cystic lesions has been reported frequently. EBUS-TBNA a reassuringly safe procedure with an overall complication rate than 2%, and serious adverse event of 0.14% to 0.16%. The most common complications are infections (mediastinal cyst infection seen). Patient concerns: A 28-year-old male presented the...
To explore the clinical efficacy and safety of lumbrokinase in treatment acute moderate risk pulmonary thromboembolism. Methods: The data 60 patients with thromboembolism, who were collected from January 2010 to October 2015 Hunan Provincial People's Hospital, retrospectively analyzed. According different treatments, randomly divided into a group (lumbrokinase combination low molecular heparin sequential warfarin, n=30) control (low n=30). compared between two groups. Results: Compared...
Background: Tyrosine kinases have emerged as key stimulatory drivers in several cancer-related pathways. This is particularly evident non-small cell lung cancer with regulating growth and apoptosis so on. kinase inhibitors (TKI) are one breakthrough option that could improve the life quality of patients. background: pathways, The tyrosine Introduction: study aims to find more effective inhibitors. objective: To novel multiple Methods: In this study, natural products from TargetMol may be...
Rationale: Amyloidosis is a rare disease characterized by the misfolding of autologous proteins and extracellular deposition fibrils, which can involve 1 or more vital organs in body. Nodular pulmonary amyloidosis with extensive cysts even less common. This study discusses diagnosis treatment case nodular calcification middle on chest computed tomography, reviews related literature. We hope that this will raise awareness among clinicians. Patient concerns: Multiple nodules were found...
To investigate the clinical characteristics of patients with primary pleomorphic adenoma lower respiratory tract. The manifestations, laboratory results, pathological and imaging, treatment prognosis 7 tract who were treated in Hunan Provincial People's Hospital from December 2015 to May 2020 analyzed. Among patients, 5 had cough expectoration as main other 2 no symptoms. Pleomorphic adenomas are mostly located trachea or bronchus, chest computed tomography findings circular ellipsoid...