A5018456687- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- Central Venous Catheters and Hemodialysis
- Cerebrovascular and Carotid Artery Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiomyopathy and Myosin Studies
- Gallbladder and Bile Duct Disorders
- Vascular Procedures and Complications
- Migraine and Headache Studies
- Stoma care and complications
- BRCA gene mutations in cancer
- Lipoproteins and Cardiovascular Health
- Pancreatitis Pathology and Treatment
University Hospital of Zurich
2019-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
University Children's Hospital Zurich
2024
Klinik Hirslanden
2022
University of Zurich
2019-2022
Pulmonary embolism is a known complication of coronavirus disease 2019 (COVID-19). Epidemiological population data focusing on pulmonary embolism-related mortality limited.Veneto region in Northern Italy counting 4,879,133 inhabitants 2020. All ICD-10 codes from death certificates (1st January 2018 to 31st December 2020) were examined. Comparisons made between 2020 (COVID-19 outbreak) and the average two-year period 2018-2019. All-cause, COVID-19-related following cardiovascular deaths have...
Background: The Transient Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is presumably a very rare disease characterized by local transient inflammation tissue around carotid artery. Its pathophysiology remains unknown. We performed an updated study TIPIC cases in setting multinational collaborative study. Methods: This was conducted as observational retrospective individual patient level cohort Information from all known diagnosed with literature (2005-2020) collected...
: We aimed to study the long-term safety and efficacy of oblique venous stents for post-thrombotic syndrome (PTS) with iliac vein compression.
IntroductionThe benefits of early thromboprophylaxis in symptomatic COVID-19 outpatients remain unclear. We present the 90-day results from randomised, open-label, parallel-group, investigator-initiated, multinational OVID phase III trial.MethodsOutpatients aged 50 years or older with acute were randomised to receive enoxaparin 40 mg for 14 days once daily vs. standard care (no thromboprophylaxis). The primary outcome was composite untoward hospitalisation and all-cause death within 30...
Large-bore catheter aspiration embolectomy reduces thrombus burden and right ventricle strain improves haemodynamics after pulmonary embolism (PE). Sparse data are available for patients with high-risk PE contraindications to thrombolysis or failure, particularly if veno-arterial extracorporal membrane oxygenation (VA-ECMO) is required.All acute undergoing FlowTriever® percutaneous VA-ECMO circulatory support (or standby) at the University Hospital Zurich between April 2021 August 2022 were...
Peripheral arterial disease (PAD) is one of the most prevalent cardiovascular diseases with more than 230 million people being affected worldwide. As highlighted by recent European Society Cardiology guidelines, data on epidemiology PAD urgently needed.We accessed vital registration Veneto region (Northern Italy, approximately five millions inhabitants) covering period 2008-2019. We computed annual age-standardized rates for reported as underlying cause death (UCOD) or multiple causes...
Lemierre syndrome is a thromboembolic complication following an acute bacterial infection of the head/neck area, often due to anaerobes. Data on prognostic role laboratory parameters lacking.We analyzed individual-patient level data from multinational cohort patients with Lemierre-syndrome. Patients had in and contiguous vein thrombosis or septic embolism, irrespective causal pathogen. We studied patterns white blood cell count, platelet C-reactive protein concentration investigating their...
Ultrasound-assisted catheter-directed thrombolysis (USAT) may reverse right ventricular dysfunction due to acute pulmonary embolism (PE) with a favorable safety profile.We studied intermediate-high- and high-risk PE patients who underwent USAT at the University Hospital Zurich, 2018-2022. The regimen included alteplase 10 mg per catheter over 15 h, therapeutic-dosed heparin, dosage adaptations based on routinely monitored coagulation parameters, notably anti-factor Xa activity fibrinogen. We...
Background. Fixed-dose ultrasound-assisted catheter-directed thrombolysis (USAT) rapidly improves hemodynamic parameters and reverses right ventricular dysfunction caused by acute pulmonary embolism (PE). The effectiveness of USAT for PE associated with coronavirus disease 2019 (COVID-19) is unknown. Methods results. study population this cohort consisted 36 patients an intermediate-high- or high-risk treated a fixed low-dose protocol (r-tPA 10–20 mg/15 h). Of these, 9 tested positive...
Summary: Background: The global burden of peripheral arterial disease (PAD) is substantial. Reducing the major modifiable risk factors for noncommunicable disease, including dyslipidaemia, represents a public health priority. Aim to evaluate prevalent adequate use lipid-lowering therapy (LLT) and low-density lipoprotein cholesterol (LDL-C) attainment among patients with PAD lower extremities undergoing percutaneous transluminal angioplasty. Patients methods: We screened treated at University...
Abstract The clinical spectrum of patients with coronavirus disease 2019 (COVID-19) ranges from asymptomatic cases to severe pneumonia acute respiratory distress syndrome. COVID-19 is associated an increased risk thromboembolic complications, notably pulmonary embolism and deep vein thrombosis. Arterial cardiovascular complications myocarditis have also been described in association COVID-19, but appear be less prevalent. In this report a 57-year-old man multiple splanchnic infarctions,...
Abstract Background Peripheral arterial disease is a progressive atherosclerotic with symptoms ranging from an intermittent claudication to acute critical limb ischemia and amputations. Drug-coated balloons stents were developed prevent neo-intimal proliferation restenosis after percutaneous transluminal angioplasty. Randomized controlled trials showed that drug-coated, notably paclitaxel-coated, devices reduce restenosis, late lumen loss, the need for target lesion re-vascularization...
Background Laparoscopic approach in patients with unresectable colorectal cancer avoids major laparotomy; we would like to estimate the feasibility, safety, and efficacy of laparoscopic elderly obstruction large bowel.
Essentials•The impact of thromboprophylaxis on long-term outcomes in COVID-19 outpatients is unknown.•COVID-19 were randomized to receive vs no thromboprophylaxis.•There was difference hospitalization and death or functional status after 2 years.•Early does not improve outpatients.AbstractBackgroundEarly prevent hospital admissions among with symptomatic COVID-19. Its outcomes, including long COVID symptoms performance status, unknown.ObjectivesTo assess the effects given at time acute...
There is a lack of large epidemiological studies focusing on the prevalence lymphedema. Vital registration data from United States (US) (1999-2020) and Veneto, Italy (2008-2021) were analyzed. Lymphedema-related deaths identified using disease-specific ICD-10 codes served to estimate burden disease in general population. We studied (i) lymphedema-specific proportionate mortality as proxy prevalence, (ii) lymphedema key patient subgroups, (iii) age sex-specific rates. The increased over last...
BackgroundAntithrombotic treatment may improve the disease course in non-critically ill, symptomatic COVID-19 outpatients.MethodsWe performed an individual patient-level analysis of OVID and ETHIC randomized controlled trials, which compared enoxaparin thromboprophylaxis for either 14 (OVID) or 21 days (ETHIC) vs. no outpatients with at least one additional risk factor. The primary efficacy outcome included all-cause hospitalization death within 30 from randomization. Both studies were...
Background: Pharmaco-mechanical thrombectomy (PMT) and catheter-directed thrombolysis (CDT) are therapeutic options for selected patients with acute deep vein thrombosis (DVT) to prevent post-thrombotic syndrome (PTS). Patients methods: We aimed describe the clinical characteristics outcomes of 159 symptomatic iliofemoral DVT undergoing PMT alone, CDT or followed by (bail-out) in Swiss Venous Stent Registry. The primary outcome was incidence peri-interventional major minor bleeding...
Abstract Funding Acknowledgements Type of funding sources: None. Background Data on clinical outcomes after fixed-dosed ultrasound-accelerated thrombolysis (USAT) for acute pulmonary embolism (PE) is still limited, particularly concerning safety and long-term course. Methods We studied patients with PE treated USAT at a University Hospital between 2018 2022. Patients were candidates to if fulfilled the criteria high-risk or intermediate-high risk (plus additional markers severity early...