A5029306869- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Bone fractures and treatments
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Tissue Engineering and Regenerative Medicine
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Electrospun Nanofibers in Biomedical Applications
- Blood transfusion and management
- Platelet Disorders and Treatments
- Cardiac Health and Mental Health
- Orthopedic Surgery and Rehabilitation
- COVID-19 and Mental Health
- Aortic Disease and Treatment Approaches
- Long-Term Effects of COVID-19
- Body Contouring and Surgery
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac, Anesthesia and Surgical Outcomes
- Digital Mental Health Interventions
University of Zurich
2021-2024
University Hospital of Zurich
2021-2024
University of Southampton
2024
University Hospital of Basel
2013-2022
University of Basel
2011-2022
Creative Commons
2018
Istituto Ortopedico Galeazzi
2018
Union Bank of Switzerland
2013
Hospital Base
2013
Martin Luther University Halle-Wittenberg
2000
Embryonic development, lengthening, and repair of most bones proceed by endochondral ossification, namely through formation a cartilage intermediate. It was previously demonstrated that adult human bone marrow-derived mesenchymal stem/stromal cells (hMSCs) can execute an program ectopically generate mature bone. Here we hypothesized hMSCs pushed ossification engineer scaled-up ossicle with features "bone organ," including physiologically remodeled bone, vasculature, fully functional...
It is currently unclear whether management and outcomes of critically ill patients differ between men women. We sought to assess the influence age, sex diagnoses on probability intensive care provision in cardio- neurovascular a large nationwide cohort Switzerland. Retrospective analysis 450,948 adult with neuro- cardiovascular disease admitted all hospitals Switzerland 01/2012 12/2016 using Bayesian modeling. For populations, median ages at admission were consistently higher for women than...
Rapid vascularization of clinical-size bone grafts is an unsolved challenge in regenerative medicine. Vascular endothelial growth factor-A (VEGF) the master regulator angiogenesis. Its over-expression by genetically modified human osteoprogenitors has been previously evaluated to drive osteogenic grafts, but observed cause paradoxical loss through excessive osteoclast recruitment. However, during development angiogenesis and osteogenesis are physiologically coupled VEGF expression. Here we...
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
Abstract Stromal Vascular Fraction (SVF) cells freshly isolated from adipose tissue include osteogenic- and vascular-progenitors, yet their relevance in bone fracture healing is currently unknown. Here, we investigated whether human SVF directly contribute to the repair of experimental fractures nude rats, explored feasibility/safety clinical use for augmentation upper arm elderly individuals. Human were loaded onto ceramic granules within fibrin gel implanted critical rat femoral after...
Significance It has been previously reported that hypertrophic cartilage tissues engineered from human mesenchymal stromal cells can efficiently remodel in vivo into bone organs, recapitulating developmental steps of endochondral ossification. We have here demonstrated the extracellular matrix (ECM) such cartilage, even absence a living cell component, retains frankly osteoinductive properties. The use an apoptosis-driven devitalization technique revealed importance preserving ECM integrity...
Abstract Background The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences pathophysiology between women men, sex currently not being considered the SOFA score. We aimed to investigate potential sex-specific dysfunction, as measured by score, patients with or septic shock explore outcome associations. Methods Retrospective analysis prospectively enrolled ICU admitted...
Inflammatory cytokines present in the milieu of fracture site are important modulators bone healing.Here we investigated effects interleukin-1β (IL-1β) on main events endochondral formation by human marrow mesenchymal stromal cells (BM-MSC), namely cell proliferation, differentiation and maturation/ remodelling resulting hypertrophic cartilage.Low doses IL-1β (50 pg/mL) enhanced colony-forming unitsfibroblastic (CFU-f) -osteoblastic (CFU-o) number (up to 1.5-fold) size (1.2-fold) absence...
Engineered and decellularized extracellular matrices (ECM) are receiving increasing interest in regenerative medicine as materials capable to induce cell growth/differentiation tissue repair by physiological presentation of embedded cues. However, ECM production/decellularization processes control over their composition remain primary challenges. This study reports engineering with customized properties, based on genetic manipulation immortalized death‐inducible human mesenchymal stromal...
Abstract Recapitulation of endochondral ossification (ECO) (i.e., generation marrow-containing ossicles through a cartilage intermediate) has relevance to develop human organotypic models for bone or hematopoietic cells and engineer grafts regeneration. Unlike marrow-derived stromal (also known as mesenchymal stromal/stem cells), adipose-derived (ASC) have so far failed form organ by ECO. The goal the present study was assess whether priming ASC defined stage chondrogenesis in vitro allows...
Abstract Background and Aims Increasing data suggest that stress-related neural activity (SNA) is associated with subsequent major adverse cardiovascular events (MACE) may represent a therapeutic target. Current evidence exclusively based on populations from the U.S. Asia where limited information about disease risk was available. This study sought to investigate whether SNA imaging has clinical value in well-characterized cohort of patients Europe. Methods In this single-centre study, total...
To assess the relationship between hospital patients' quality of care ratings and their experiences with health-related information exchanges communication during hospitalization. Cross-sectional multivariate dimensional analysis data from a experience questionnaire patients comparing scores across three levels reported satisfaction. Five thousand nine hundred fifty-two Swiss University Hospital responded to at discharge 2010. Survey questions measuring evaluation care, patient loyalty...
Abstract Background Women are overrepresented amongst individuals suffering from post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Methods Findings By using Bayesian models comprising >200 co-variates, we assessed the social context in addition to biological data a multi-centre prospective cohort study 2927 (46% women) Switzerland. more...
A widely discussed design issue in patient satisfaction questionnaires is the optimal length and labelling of answering scale. The aim present study was to compare intra-individually answers on two response scales five general questions evaluating patients' perception hospital care.Between November 2011 January 2012, all in-hospital patients at a Swiss University Hospital received questionnaire an adjectival scale with three four labelled categories (LS) redundant displayed 11-point...
Macrophages are key players in healing processes. However, little is known on their capacity to modulate the differentiation potential of mesenchymal stem/stromal cells (MSC). Here we investigated whether macrophages (Mf) with, respectively, pro-inflammatory and tissue-remodeling traits differentially chondrogenesis bone marrow derived-MSC (BM-MSC). We demonstrated that coculture collagen scaffolds BM-MSC with Mf derived from monocytes polarized M-CSF (M-Mf), but not GM-CSF (GM-Mf) resulted...
Digital health interventions are being increasingly incorporated into care workflows to improve the efficiency of patient care. In turn, sustained engagement with digital can maximize their benefits toward outcomes. this viewpoint, we outline a dynamic by using various communication channels and potential use omnichannel integrate these channels. We conceptualize novel journey where multiple web-based offline integrated through "digital twin." The principles implementing for twins also...
Timely management of acute myocardial infarction (AMI) and stroke has undergone impressive progress during the last decade. However, it is currently unknown whether both sexes have profited equally from improved strategies. We sought to analyze sex-specific temporal trends in intensive care unit (ICU) admission mortality younger patients presenting with AMI or Switzerland.Retrospective analysis 16,954 aged 18 ≤ 52 years admitted Swiss ICUs between 01/2008 12/2019.Over a period 12 years, ICU...
The gold standard treatment of large segmental bone defects is autologous transfer, which suffers from low availability and additional morbidity. Tissue engineered able to engraft orthotopically a suitable animal model for pre-clinical testing are direly needed. This study aimed evaluate engraftment tissue-engineered with different prevascularization strategies in novel defect the rabbit humerus. Decellularized matrix (Tutobone) seeded marrow mesenchymal stromal cells was used directly or...
Abstract Engineered and devitalized hypertrophic cartilage (HC) has been proposed as bone substitute material, potentially combining the features of osteoinductivity, resistance to hypoxia, capacity attract blood vessels, customization potential for specific indications. However, in comparison with vital tissues, HC grafts have reduced efficiency formation longer remodeling times. We tested hypothesis that freshly harvested stromal vascular fraction (SVF) cells from human adipose...
In Brief this prospective, observational study, we evaluated whether transesophageal echocardiography allows for monitoring left ventricular segmental wall motion during cardiac displacement off-pump coronary artery bypass (OPCAB) surgery. On the basis of a pilot study that showed frequent loss transgastric views OPCAB surgery, analyzed only midesophageal views. The 4-chamber view, 2-chamber and long-axis view were recorded in 60 patients after opening chest placing an epicardial stabilizer...