A5102927436- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Occupational exposure and asthma
- Heavy Metal Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Respiratory viral infections research
- Immunotoxicology and immune responses
- Pediatric health and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Blood disorders and treatments
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Lymphoma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Dental Radiography and Imaging
- Cystic Fibrosis Research Advances
- Trace Elements in Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chronic Lymphocytic Leukemia Research
- Hops Chemistry and Applications
- Inflammatory Myopathies and Dermatomyositis
- Inflammatory mediators and NSAID effects
St. John Fisher College
2024
Florida College
2024
University of Florida
2024
Royal Cornwall Hospital Trust
2013-2024
Royal Cornwall Hospital
2005-2023
University of Manchester
2012-2023
Indiana Hand to Shoulder Center
2023
University of Miami
2023
Thomas Jefferson University
2023
Creative Commons
2023
To investigate the potential relation between cumulative exposure to cigarette smoking in patients with or without rheumatoid arthritis (RA) and a positive family history of disease.239 outpatient based RA were compared 239 controls matched for age, sex, social class. A detailed was recorded expressed as pack years smoked. Conditional logistic regression used calculate association The also interviewed about disease if first second degree relative had RA. at time study directly that their...
BackgroundThe risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated in around 5% patients, which led to intensive monitoring strategies. However, the evidence is derived retrospective studies that underreported factors disease. We evaluated long-term MTX therapy on a longitudinal cohort study using two non-invasive markers.MethodBetween 2014-2021, adult patients diagnosed with Rheumatoid Arthritis (RA) or psoriasis for ≥2 years were recruited...
Two groups of prepubertal children with severe obstructive sleep apnea syndrome received continuous positive airway pressure (CPAP) treatment using a nasal mask. The five in group A had CPAP only hospital setting; the B at home as well. Four these children, who have now been followed for long 10 months, adapted well to home. problems encountered treatment, such poor cooperation from parents, allergic rashes, eye irritation resulting air leaks, are discussed. Despite problems, is valid...
To examine the potential of chronic severe bacterial infection to generate rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs), by studying patients with bronchiectasis (BR) alone BR arthritis (BR/RA).We studied 122 alone, 50 BR/RA, RA without lung disease, as well 87 asthma 79 healthy subjects controls. RF levels were measured using an automated analyzer, cyclic citrullinated peptide 2 (CCP-2) was used detect ACPAs. The fine specificities α-enolase 1 (CEP-1),...
Abstract Objective To determine whether the relationship between smoking and disease severity in women with rheumatoid arthritis (RA) is associated polymorphism at glutathione S‐transferase (GST) M1 locus. Methods Genotyping for GSTM1 was carried out using polymerase chain reaction methodology on 164 established RA. Smoking history obtained each patient. Radiographic damage measured by Larsen score, functional outcome assessed Health Assessment Questionnaire (HAQ). Data were analyzed...
The effect of dipotassium ethylenediaminetetra-acetic acid (EDTA) on platelet count and mean volume (MPV) was evaluated using two routine measurement systems, a Coulter S Plus (Phase 1) (S+) Technicon H6000 (H6000). In normal subjects (n=29) MPV increased by 17% during 39 h storage in EDTA when measured the S+. contrast decreased 22% H6000. differences up to 40% were observed between systems. Concomitant counts, both changed less than 4%. A mathematical model variation with time constructed,...
Abstract Aim Patients with rheumatoid arthritis ( RA ) and co‐existent bronchiectasis BRRA have a five‐fold increased mortality compared to alone. Yet previous studies found no difference in clinical serological markers of disease severity between patients However, activity measures such as Disease Activity Score 28 joints – C‐reactive protein DAS 28‐ CRP anti‐cyclic citrullinated peptide antibodies (anti‐ CCP not been studied, so we assessed these parameters Methods n = 53) had...
To analyse the relationship between rheumatoid factor (RF) titre, smoking and HLA-DRB1 alleles coding a "shared epitope" (SE) in relation to anti-citrullinated protein antibody (ACPA) positivity arthritis (RA).RA patients (n = 658) attending rheumatology clinics Cornwall, UK (cohort 1) were stratified according RF ACPA pack years at diagnosis. A further 409 RA from North Staffordshire, 2) studied confirm levels, SE status.In cohort 1 there was trend (p<0.01) of increasing rates with levels...
The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination proteins thought to be an initiating event. In addition, it increasingly evident that the lung can a potential site for generation autoimmune triggers before development joint disease. Here, we identified serum levels galectin-9 (Gal-9), pleiotropic immunomodulatory protein, are elevated in RA patients, and even further increased patients with comorbid bronchiectasis, disease caused by chronic inflammation....
Objective: The objective of the study was to determine whether cadmium-derived materials induce intracellular protein citrullination. Methods: Human A549 lung epithelial cells were exposed cadmium in soluble and nanoparticulate forms represented by chloride (CdCl 2 ) oxide (CdO), respectively, their combinations with ultrafine carbon black (ufCB) produced high temperature combustion, imitating cigarette burning. Protein citrullination cell lysates analyzed Western immunoblotting verified...
Objectives It has been suggested that exposure to heavy metal cadmium (Cd) may contribute a high risk of developing rheumatoid arthritis (RA). This study was investigate the association RA prevalence and serum concentrations Cd other metals through large survey data analysis. Design A retrospective cross-sectional study. Setting Large population in Korea. Participants 53 829 subjects participated Korean National Health Nutrition Examination Survey (KNHANES) from 2008 2013. Interventions...
<h3>OBJECTIVES</h3> It was noted that treatment of a patient with acute mania by haloperidol associated marked improvement in activity rheumatoid arthritis. The objective this study to examine the effects on inflammatory cytokine release vitro, as potential mechanism explain vivo anti-inflammatory haloperidol. <h3>METHODS</h3> effect production cytokines interleukin 1β (IL1β) and tumour necrosis factor α (TNFα) measured bacterial lipopolysaccharide stimulated whole blood cultures promonocyte...
Seropositive rheumatoid arthritis (RA) has been considered to be a stochastic process;1 however, careful consideration of the natural history RA and examination some known environmental risk factors would suggest otherwise. Rather than set random initiating events, it is hypothesized here that there an overarching etiological trigger factor account for disease development. The lung site seropositive as result local anti-citrullinated peptide (anti-CCP) antibody generation.2 In this paper,...
Summary The effect of dipotassium ethylenediaminetetraaceticacid (EDTA) on the platelet count and mean volume (MPV) was evaluated using two routine measurement systems, a Coulter S Plus Phase 1 (S+) Technicon H6000 (H6000). In normal subjects (n = 29) MPV increased by 17% during 39 h storage in EDTA when measured +. contrast decreased 22% H6000. differences up to 40% were observed between systems. Concomitant counts, both changed less than 4%. Using anticoagulant sodium citrate prostaglandin...
Multiple chronic disease risks have been identified in Italian furnace workers. A range of potential toxins foundry dust. We suggest that the heavy metal cadmium (Cd) plays an important role development diseases, notably rheumatoid arthrits, and propose research into mechanism action be undertaken to discover aetiology this link.