A5101525928- Finite Group Theory Research
- Coding theory and cryptography
- Pancreatic function and diabetes
- graph theory and CDMA systems
- Advanced Algebra and Geometry
- Diabetes Management and Research
- Rings, Modules, and Algebras
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Geometric and Algebraic Topology
- Algebraic Geometry and Number Theory
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Advanced Topics in Algebra
- Pancreatitis Pathology and Treatment
- Cardiac Arrest and Resuscitation
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal motility and disorders
- SARS-CoV-2 detection and testing
- Cellular transport and secretion
- DNA and Biological Computing
- Intensive Care Unit Cognitive Disorders
RWTH Aachen University
2003-2025
Heinrich Heine University Düsseldorf
2020-2024
St. Josef-Hospital
2009-2023
GlaxoSmithKline (Belgium)
2023
Ruhr University Bochum
2011-2023
Katholisches Klinikum Bochum
2017-2023
beta-Cell mass declines progressively during the course of diabetes, and various antidiabetic treatment regimens have been suggested to modulate beta-cell mass. However, imaging methods allowing monitoring changes in vivo not yet become available. We address whether pancreatic area can be assessed by functional test insulin secretion humans.A total 33 patients with chronic pancreatitis (n = 17), benign adenomas 13), tumors ampulla Vater 3) at stages glucose tolerance were examined an oral...
Critically ill burn patients face severe metabolic stress, divided into early ebb and late flow phases, causing dysglycemia. While detrimental effects of hyper- hypoglycemia in have been reported over the entire stay, its impact during phases remains unexplored. This study is first to investigate phase-separated dysglycemia for outcome prediction. retrospective, single-center observational examined ICU between 2009 2022. Non-severe (ABSI<7) (ABSI≥7) were investigated separately. Furthermore,...
Diabetes frequently develops in patients with chronic pancreatitis. We examined the alterations glucagon response to hypoglycemia and oral glucose administration diabetes due pancreatitis.Ten secondary pancreatitis were compared 13 type 2 10 healthy control subjects. A stepwise hypoglycemic clamp an tolerance test (OGTT) performed.Glucose levels during OGTT higher lower subjects (P < 0.0001). Insulin C-peptide reduced, glucose-induced suppression of was impaired both groups (all P 0.0001 vs....
Delayed cerebral ischemia (DCI) is a severe complication following aneurysmal subarachnoid hemorrhage (aSAH), linked to poor functional outcomes and prolonged intensive care unit (ICU) stays. Timely DCI diagnosis crucial but remains challenging. Dysregulated blood glucose, commonly observed after aSAH, may impair the constant glucose supply that vital for brain function, potentially contributing DCI. This study aimed assess whether indices could help identify at-risk patients improve...
For a finite group G let Γ(G) denote the graph defined on non-identity elements of in such way that two distinct vertices are connected by an edge if and only they generate G. In this paper it is shown contains Hamiltonian cycle for many groups
The glucose-induced decline in glucagon levels is often lost patients with type 2 diabetes. It unclear whether this due to an independent defect alpha-cell function or secondary the impairment insulin secretion. We examined a partial pancreatectomy humans would also impair postchallenge concentrations and, if so, could be attributed reduction levels.Thirty-six pancreatic tumours chronic pancreatitis were studied before and after approximately 50% 240-min oral glucose challenge, plasma of...
Abstract Background Diagnosis of intensive care unit acquired weakness (ICUAW) is challenging. Pathogenesis underlying critical illness polyneuromyopathy (CIPNM) remains incompletely understood. This exploratory study investigated whether longitudinal neuromuscular ultrasound examinations and cytokine analyses in correlation to classical clinical electrophysiological assessment contribute the understanding CIPNM. Methods Intensive patients were examined every 7 days until discharge from...
Inflammatory neuropathies with pathogenic involvement of the nodes Ranvier through autoantibodies have been increasingly characterized in past years. The so-called anti-pan-NF-associated caused by simultaneous existence anti-Neurofascin-186/-140 and -155-antibodies are extremely rare cause life-threatening symptoms. Therapeutic strategies needed as symptoms may be not respond to standard first-line CIDP treatment. We report a case 52-year-old male anti-pan-neurofascin (NF) (-155,...
ABSTRACT Background GBP510 vaccine contains self-assembling, recombinant nanoparticles displaying SARS-CoV-2 spike receptor-binding domains. We report interim phase 3 immunogenicity results for adjuvanted with AS03 (GBP510/AS03) compared ChAdOx1-S (Vaxzevria, AstraZeneca) up to 2 weeks after the second dose, and safety data a median of 2.5 months follow-up. Methods Randomised, active-controlled, observer-blinded, multinational study: Cohort 1 (no history infection/COVID-19 vaccination,...
Abstract The epidemiology of Q fever in Germany was examined by reviewing relevant studies since 1947 and analyzing available surveillance data 1962. average annual incidence nationwide from 1979 to 1989 0.8 per million 1990 1999, 1.4 million. mean 1999 ranged a minimum 0.1 several northern states 3.1 Baden-Württemberg, the South. We identified 40 documented outbreaks 1947; 24 these sheep were implicated as source transmission. seasonality community has shifted predominantly winter-spring...
Introduction Hyperproinsulinaemia has been reported in patients with type 2 diabetes. It is unclear whether this due to an intrinsic defect β-cell function or secondary the increased demand on β-cells. We investigated hyperproinsulinaemia also present diabetes, and proinsulin levels are associated impaired area function. Patients methods Thirty-three without diabetes pancreatic diseases were studied prior surgery. Intact total compared measures of insulin secretion action. Results Fasting...
Abstract Mechanical ventilation is essential in intensive care treatment but leads to diaphragmatic atrophy, which turn contributes prolonged weaning and increased mortality. One approach prevent atrophy while achieving pulmonary electrical stimulation of the phrenic nerve. To automize nerve resulting lung protective tidal volumes with lowest possible currents, mathematical models are required. Nerve often complex, so many parameters have be identified prior implementation. This paper...
In this paper, we classify all the multiplicity-free permutation characters of sporadic simple groups and their automorphism groups. This project is an application group theory system GAP, its character table library, library tables marks.
Hyperprolinemia type 2 (HPII) is a rare autosomal recessive disorder of the proline metabolism, that affects ALDH4A1 gene. So far only four different pathogenic mutations are known. The manifestation mostly in neonatal age, early infancy or childhood.The 64-years female patient had long history abdominal pain, and episode an acute neuritis. Ten years later she was admitted into neurological intensive-care-unit with multiple generalized epileptic seizures, vertical gaze palsy accompanied by...
This is a collection of examples showing how the GAP system can be used to compute information about probabilistic generation finite almost simple groups. It includes all that were needed for computational results in paper "Probabilistic groups, II" by Thomas Breuer, Robert M. Guralnick, and William Kantor. The purpose this writeup twofold. On one hand, computations are documented way. other code shown as test input automatic checking data functions used.