A5059475935- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Plant Virus Research Studies
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Syncope and Autonomic Disorders
- Multiple Sclerosis Research Studies
- Drug-Induced Ocular Toxicity
- Cardiac pacing and defibrillation studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Polyomavirus and related diseases
St. Josef-Hospital
2020-2022
Ruhr University Bochum
2020-2022
General Hospital of Attica
2013
Inflammatory neuropathies with pathogenic involvement of the nodes Ranvier through autoantibodies have been increasingly characterized in past years. The so-called anti-pan-NF-associated caused by simultaneous existence anti-Neurofascin-186/-140 and -155-antibodies are extremely rare cause life-threatening symptoms. Therapeutic strategies needed as symptoms may be not respond to standard first-line CIDP treatment. We report a case 52-year-old male anti-pan-neurofascin (NF) (-155,...
Background: Up to 20% of patients with chronic immune-mediated sensorimotor neuropathies (CIN) do not respond adequately first-line therapies. However, studies on further treatment are scarce. Methods: We analyzed retrospectively 200 CIN regarding disease characteristics and response therapy cyclophosphamide (CYP), rituximab (RTX), bortezomib (BTZ). Treatment was defined as improvement or stabilization inflammatory neuropathy cause overall disability score (INCAT-ODSS). Results: A total 48...
Monitoring of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is challenging in daily medical practice because the interrelationship between clinical disability, CIDP subtype, and neuronal degeneration still elusive. The aim this prospective cohort study was to investigate role different electrophysiological variables monitoring.Comprehensive bilateral nerve conduction studies (NCS) structured examinations were performed 95 typical variants (age at inclusion...
Abstract We report the case of a 27‐year‐old patient with subacute anti‐neurofascin‐155 neuropathy bifacial palsy, who showed excellent response to rituximab. provide longitudinal data established clinical scores, nerve conduction studies, antibody titers, and novel imaging methods (nerve ultrasonography corneal confocal microscopy). Clinical electrophysiological improvement followed reduction serum titer correlated inflammatory cellular infiltrates whereas increase in cross‐sectional area...
Abstract Objective To evaluate the European Federation of Neurological Societies (EFNS)/Peripheral Nerve Society (PNS) diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP) in a cohort patients diagnosed and treated CIDP tertiary university hospital. Methods In monocentric retrospective study 203 patients, according to expert opinion, we evaluated EFNS/PNS criteria. Clinical course nerve conduction studies (NCS) over 1 year from first referral were studied....
Background and purpose Monitoring of the disease course patients with chronic inflammatory demyelinating polyneuropathy (CIDP) remains challenging because nerve conduction studies do not adequately correlate functional disability. The prognostic value pathological spontaneous activity (PSA) in needle electromyography (EMG) different CIDP subgroups a longitudinal context has, to date, been analysed. We aimed determine whether PSA was marker or cohort CIDP. Methods A total 127 spectrum...
Chronic inflammatory demyelinating polyneuropathy (CIDP) may have a similar clinical and electrophysiological presentation to non-inflammatory axonal polyneuropathies (NIAPs) when secondary damage occurs. We aimed investigate if nerve ultrasound can help differentiate CIDP with additional from NIAP.In retrospective analysis, the cross-sectional area (CSA) of peripheral nerves measured by at six suitable sites was compared in 95 patients 82 NIAP. developed adjusted Bochum score (aBUS) ranging...
We evaluated muscle echointensity as a marker for secondary axonal damage in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) using ultrasonography. Findings were correlated clinical disability and muscular strength.Eighty CIDP (40 typical 40 atypical CIDP) examined clinically, including assessment of Medical Research Council (MRC) sum score Inflammatory Neuropathy Cause Treatment Overall Disability Sum Score (INCAT-ODSS). Echointensity eight proximal distal muscles the...
We describe the disease course of a 35-year-old female with an autoimmune mediated neuropathic postural tachycardia syndrome (PoTS), who responded to immunoglobulin therapy and stabilized on maintenance subcutaneous (SCIg). provide longitudinal data clinical scores, tilt-table results antibody titers. Initial treatment intravenous caused infusion-related side-effects whereas SCIg was well tolerated improved symptoms quality life. Clinical improvement correlated reduction serum titers 22...
Pain, fatigue and depression in chronic inflammatory demyelinating polyneuropathy (CIDP) are often underestimated, as the focus lies on sensorimotor dysfunction gait instability. The aim of this study was to investigate their prevalence, characteristics contribution disability a prospective cohort 84 patients with CIDP.Pain, fatigue, quality life were measured using Pain Detect Questionnaire, Krupp's Fatigue Severity Scale, Beck Depression Inventory II German Short-Form 36 Health Survey....